Research Repository

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Reviving phage therapy for the treatment of cholera (2018)
Journal Article
Bhandare, S., Colom, J., Baig, A., Ritchie, J. M., Bokhari, H., Shah, M. A., …Atterbury, R. J. (2018). Reviving phage therapy for the treatment of cholera. Journal of Infectious Diseases, doi:10.1093/infdis/jiy563

Cholera remains a major risk in developing countries, particularly after natural or man-made disasters. Vibrio cholerae El Tor is the most important cause of these outbreaks, and is becoming increasingly resistant to antibiotics, so alternative thera... Read More

Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal (2018)
Journal Article
Sarkar, B., Sarkar, S., Das, M., Bhowmick, T., Koley, H., Atterbury, R., & Chakrabarti, A. (2018). Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal. Journal of Global Infectious Diseases, 10(2), doi:10.4103/jgid.jgid_37_17. ISSN 0974-777X

Objectives: We have isolated a total of five newer cholera phages which are novel broad host range to incorporate with the existing phage typing schemes for an extended typing scheme. Materials and Methods: These newly isolated phages were well chara... Read More

Complete genome sequences of seven Vibrio cholerae phages isolated in China (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Su, J., Barrow, P. A., & Atterbury, R. J. (2017). Complete genome sequences of seven Vibrio cholerae phages isolated in China. Genome Announcements, 5(47), doi:10.1128/genomeA.01019-17. ISSN 2169-8287

The complete genome sequences of seven closely related Vibrio cholerae phages isolated from environmental sites in southeastern China are reported here. Phages QH, CJY, H1, H2, H3, J2, and J3 are members of the Podoviridae family and are highly simil... Read More

Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29 (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Hooton, S. P., Barrow, P. A., & Atterbury, R. J. (2017). Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29. Genome Announcements, 5(46), doi:10.1128/genomeA.01013-17. ISSN 2169-8287

The complete genomes of two Vibrio cholerae bacteriophages of potential interest for cholera bacteriophage (phage) therapy were sequenced and annotated. The genome size of phage 24 is 44,395 bp encoding 71 putative proteins, and that of phage X29 is... Read More

Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection (2017)
Journal Article
Baig, A., Colom, J., Barrow, P., Schouler, C., Moodley, A., Lavigne, R., & Atterbury, R. J. (2017). Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection. Frontiers in Microbiology, 8, doi:10.3389/fmicb.2017.01652. ISSN 1664-302X

We have performed microbiological and genomic characterization of an historic collection of nine bacteriophages, specifically infecting a K1 E. coli O18:K1:H7 ColV+ strain. These phages were isolated from sewage and tested for their efficacy in vivo... Read More

Investigation into the animal species contents of popular wet pet foods (2015)
Journal Article
Maine, I. R., Atterbury, R. J., & Chang, K. (2015). Investigation into the animal species contents of popular wet pet foods. Acta Veterinaria Scandinavica, 57(1), doi:10.1186/s13028-015-0097-z. ISSN 1751-0147

Background: The use of the generic term “meat and animal derivatives” in declared ingredient lists of pet foods in the European Union is virtually universal. In the wake of the 2013 “horse meat scandal” in the human food chain, we examined the presen... Read More

Fleas and smaller fleas: virotherapy for parasite infections (2013)
Journal Article
Hyman, P., Atterbury, R. J., & Barrow, P. (2013). Fleas and smaller fleas: virotherapy for parasite infections. Trends in Microbiology, 21(5), doi:10.1016/j.tim.2013.02.006. ISSN 0966-842X

Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We prop... Read More

Application of a bacteriophage cocktail to reduce Salmonella Typhimurium U288 contamination on pig skin (2011)
Journal Article
Hooton, S. P., Atterbury, R. J., & Connerton, I. F. (2011). Application of a bacteriophage cocktail to reduce Salmonella Typhimurium U288 contamination on pig skin. International Journal of Food Microbiology, 151(2), doi:10.1016/j.ijfoodmicro.2011.08.015. ISSN 0168-1605

Multidrug-resistant Salmonella Typhimurium U288 is a significant pathogen of pigs, accounting for over half of all outbreaks on UK pig production premises. The potential of this serovar, and other salmonellae, to enter the food chain during the slaug... Read More

Effect of delivery method on the efficacy of Salmonella vaccination in chickens (2010)
Journal Article
Atterbury, R. J., Morris, V., Harrison, D., Tucker, V., Allen, V., Davies, R., & Carrique-Mas, J. (2010). Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167(5), doi:10.1136/vr.b4884. ISSN 0042-4900

To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination w... Read More

Bacteriophage therapy to reduce Salmonella colonization of broiler chickens (2007)
Journal Article
Atterbury, R. J., Van Bergen, M., Ortiz, F., Lovell, M., Harris, J., De Boer, A., …Barrow, P. (2007). Bacteriophage therapy to reduce Salmonella colonization of broiler chickens. Applied and Environmental Microbiology, 73(14), doi:10.1128/AEM.00049-07. ISSN 0099-2240

Acute enteric infections caused by salmonellas remain a major public health burden worldwide. Poultry, particularly chickens, are known to be the main reservoir for this zoonotic pathogen. Although some progress has been made in reducing Salmonella c... Read More

Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens (2005)
Journal Article
Loc Carrillo, C., Atterbury, R. J., El-Shibiny, A., Connerton, P. L., Dillon, E., Scott, A., & Connerton, I. F. (2005). Bacteriophage therapy to reduce Campylobacter jejuni colonization of broiler chickens. Applied and Environmental Microbiology, 71(11), doi:10.1128/AEM.71.11.6554-6563.2005. ISSN 0099-2240

Colonization of broiler chickens by the enteric pathogen Campylobacter jejuni is widespread and difficult to prevent. Bacteriophage therapy is one possible means by which this colonization could be controlled, thus limiting the entry of campylobacter... Read More

Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca (2005)
Journal Article
Atterbury, R. J., Dillon, E., Swift, C., Connerton, P. L., Frost, J., Dodd, C. E., …Connerton, I. F. (2005). Correlation of Campylobacter bacteriophage with reduced presence of hosts in broiler chicken ceca. Applied and Environmental Microbiology, 71(8), doi:10.1128/AEM.71.8.4885-4887.2005. ISSN 0099-2240

Campylobacter jejuni and Campylobacter-specific bacteriophage were enumerated from broiler chicken ceca selected from 90 United Kingdom flocks (n = 205). C. jejuni counts in the presence of bacteriophage (mean log10 5.1 CFU/g) were associated with a... Read More

Isolation and characterization of Campylobacter bacteriophages from retail poultry (2003)
Journal Article
Atterbury, R. J., Connerton, P. L., Dodd, C. E., Rees, C. E., & Connerton, I. F. (2003). Isolation and characterization of Campylobacter bacteriophages from retail poultry. Applied and Environmental Microbiology, 69(8), doi:10.1128/AEM.69.8.4511-4518.2003. ISSN 0099-2240

The ability of phages to survive processing is an important aspect of their potential use in the biocontrol of Campylobacter in poultry production. To this end, we have developed a procedure to recover Campylobacter bacteriophages from chilled and fr... Read More

The effect of pH on glucoamylase production, glycosylation and chemostat evolution of Aspergillus niger (2001)
Journal Article
Wallis, G. L., Swift, R. J., Atterbury, R. J., Trappe, S., Rinas, U., Hemming, F. W., …Peberdy, J. F. (2001). The effect of pH on glucoamylase production, glycosylation and chemostat evolution of Aspergillus niger. BBA - General Subjects, 1527(3), doi:10.1016/S0304-4165(01)00145-3. ISSN 0304-4165

The effect of ambient pH on production and glycosylation of glucoamylase (GAM) and on the generation of a morphological mutant produced by Aspergillus niger strain B1 (a transformant containing an additional 20 copies of the homologous GAM glaA gene)... Read More