All Outputs (2)

Δ9-tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors (2016)
Journal Article
Shang, V. C., Kendall, D. A., & Roberts, R. E. (in press). Δ9-tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors. Biochemical Pharmacology, 120, https://doi.org/10.1016/j.bcp.2016.09.008

Despite pharmacological treatment, bronchial hyperresponsiveness continues to deteriorate as airway remodelling persists in airway inflammation. Previous studies have demonstrated that the phytocannabinoid Δ9-tetrahydrocannabinol (THC)reverses bronch... Read More about Δ9-tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors.

Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria (2016)
Journal Article
Almukhtar, H., Garle, M., Smith, P., & Roberts, R. E. (2016). Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria. Toxicology and Applied Pharmacology, 305, https://doi.org/10.1016/j.taap.2016.06.024

Statins induce acute vasorelaxation which may contribute to the overall benefits of statins in the treatment of cardiovascular disease. The mechanism underlying this relaxation is unknown. As statins have been shown to alter mitochondrial function, i... Read More about Effect of simvastatin on vascular tone in porcine coronary artery: potential role of the mitochondria.