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Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes (2019)
Journal Article
Izquierdo, A., Fahrenberger, M., Persampieri, T., Benedict, M. Q., Giles, T., Catteruccia, F., …Dottorini, T. (2019). Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes. Life Science Alliance, 2(1), e00191. doi:10.26508/lsa.201800191

Modifications in gene expression determine many of the phenotypic differentiations between closely related species. This is particularly evident in reproductive tissues, where evolution of genes is more rapid, facilitating the appearance of distinct... Read More

Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures (2018)
Journal Article
Cong, W., Dottorini, T., Khan, F., Emes, R. D., Zhang, F., Zhou, C., …Zhu, X. (2018). Acute Toxoplasma gondii infection in cats induced tissue-specific transcriptional response dominated by immune signatures. Frontiers in Immunology, 9, doi:10.3389/fimmu.2018.02403. ISSN 1664-3224

RNA-sequencing was used to detect transcriptional changes in six tissues of cats, seven days after T. gondii infection. A total of 737 genes were differentially expressed (DEGs), of which 410 were up-regulated and 327 were down-regulated. The liver e... Read More

The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus (2018)
Journal Article
Blanchard, A. M., Jolley, K. A., Maiden, M. C., Coffey, T. J., Maboni, G., Staley, C. E., …Tötemeyer, S. (in press). The applied development of a tiered multilocus sequence typing (MLST) scheme for Dichelobacter nodosus. Frontiers in Microbiology, 9, doi:10.3389/fmicb.2018.00551. ISSN 1664-302X

Dichelobacter nodosus (D. nodosus) is the causative pathogen of ovine footrot, a disease that has a significant welfare and financial impact on the global sheep industry. Previous studies into the phylogenetics of D. nodosus have focused on Australia... Read More

Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy (2018)
Journal Article
Saad, N., Alberio, R., Johnson, A. D., Emes, R. D., Giles, T. C., Clarke, P., …Allegrucci, C. (2018). Cancer reversion with oocyte extracts is mediated by cell cycle arrest and induction of tumour dormancy. Oncotarget, 9(22), doi:10.18632/oncotarget.24664

Inducing stable control of tumour growth by tumour reversion is an alternative approach to cancer treatment when eradication of the disease cannot be achieved. The process requires re-establishment of normal control mechanisms that are lost in canc... Read More

Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists (2018)
Journal Article
Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., …Dockrell, D. H. (in press). Opsonic phagocytosis in chronic obstructive pulmonary disease is enhanced by Nrf2 agonists. American Journal of Respiratory and Critical Care Medicine, doi:10.1164/rccm.201705-0903OC. ISSN 1073-449X

Rationale: Previous studies have identified defects in bacterial phagocytosis by alveolar macrophages (AM) in patients with chronic obstructive pulmonary disease (COPD) but the mechanisms and clinical consequences remain incompletely defined. Object... Read More

Identification of stable reference genes for quantitative PCR in koalas (2018)
Journal Article
Sarker, N., Fabijan, J., Emes, R. D., Hemmatzadeh, F., Meers, J., Moreton, J., …Tarlinton, R. E. (in press). Identification of stable reference genes for quantitative PCR in koalas. Scientific Reports, 8, doi:10.1038/s41598-018-21723-0. ISSN 2045-2322

To better understand host and immune response to diseases, gene expression studies require identification of reference genes with stable expression for accurate normalisation. This study describes the identification and testing of reference genes wit... Read More

Complete genome sequences of seven Vibrio cholerae phages isolated in China (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Su, J., Barrow, P. A., & Atterbury, R. J. (2017). Complete genome sequences of seven Vibrio cholerae phages isolated in China. Genome Announcements, 5(47), doi:10.1128/genomeA.01019-17. ISSN 2169-8287

The complete genome sequences of seven closely related Vibrio cholerae phages isolated from environmental sites in southeastern China are reported here. Phages QH, CJY, H1, H2, H3, J2, and J3 are members of the Podoviridae family and are highly simil... Read More

Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29 (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Hooton, S. P., Barrow, P. A., & Atterbury, R. J. (2017). Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29. Genome Announcements, 5(46), doi:10.1128/genomeA.01013-17. ISSN 2169-8287

The complete genomes of two Vibrio cholerae bacteriophages of potential interest for cholera bacteriophage (phage) therapy were sequenced and annotated. The genome size of phage 24 is 44,395 bp encoding 71 putative proteins, and that of phage X29 is... Read More

A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells (2017)
Journal Article
Al-Mayyahi, R. S., Sterio, L. D., Connolly, J. B., Adams, C. F., Al-Tumah, W. A., Sen, J., …Chari, D. M. (2018). A proteomic investigation into mechanisms underpinning corticosteroid effects on neural stem cells. Molecular and Cellular Neuroscience, 86, doi:10.1016/j.mcn.2017.11.006. ISSN 1044-7431

Corticosteroids (CSs) are widely used clinically, for example in pediatric respiratory distress syndrome, and immunosuppression to prevent rejection of stem cell transplant populations in neural cell therapy. However, such treatment can be associated... Read More

A distinct bacterial dysbiosis associated skin inflammation in ovine footrot (2017)
Journal Article
Maboni, G., Blanchard, A. M., Frosth, S., Stewart, C. E., Emes, R. D., & Tötemeyer, S. (in press). A distinct bacterial dysbiosis associated skin inflammation in ovine footrot. Scientific Reports, 7, doi:10.1038/srep45220. ISSN 2045-2322

Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the developmen... Read More

Evolution of complexity in the zebrafish synapse proteome (2017)
Journal Article
Bayes, A., Collins, M. O., Reig-Vader, R., Gou, G., Goulding, D., Izquierdo, A., …Grant, S. G. (in press). Evolution of complexity in the zebrafish synapse proteome. Nature Communications, doi:10.1038/ncomms14613. ISSN 2041-1723

The proteome of human brain synapses is highly complex and mutated in over 130 diseases. This complexity arose from two whole genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases, however its synapse pro... Read More

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3 (2017)
Journal Article
Olcese, C., Patel, M. P., Shoemark, A., Kiviluoto, S., Legendre, M., Williams, H. J., …Mitchison, H. M. (in press). X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3. Nature Communications, 8, doi:10.1038/ncomms14279. ISSN 2041-1723

By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid. Primary ciliary dyskinesia (PCD) is an autosomal recessi... Read More

DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis (2016)
Journal Article
with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics, doi:10.2217/epi-2016-0042. ISSN 1750-1911

Aim: A proof-of-concept study to explore whether DNA methylation at first diagnosis is associated with response to disease-modifying antirheumatic drugs (DMARDs) in patients with early rheumatoid arthritis (RA). Patients & methods: DNA methylation wa... Read More