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DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis (2016)
Journal Article
Glossop, J. R., Nixon, N. B., Emes, R. D., Sim, J., Packman, J. C., Mattey, D. L., …Fryer, A. A. (2016). DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics, 9(4), https://doi.org/10.2217/epi-2016-0042

Aim: A proof-of-concept study to explore whether DNA methylation at first diagnosis is associated with response to disease-modifying antirheumatic drugs (DMARDs) in patients with early rheumatoid arthritis (RA). Patients & methods: DNA methylation wa... Read More about DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.

A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes (2016)
Journal Article
Sulaiman, A. A., Zolnierczyk, K., Japa, O., Owen, J. P., Maddison, B. C., Emes, R. D., …Flynn, R. J. (2016). A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes. PLoS Pathogens, 12(11), Article 1005991. https://doi.org/10.1371/journal.ppat.1005991

© 2016 Sulaiman et al. The trematode Fasciola hepatica is responsible for chronic zoonotic infection globally. Despite causing a potent T-helper 2 response, it is believed that potent immunomodulation is responsible for rendering this host reactive n... Read More about A Trematode Parasite Derived Growth Factor Binds and Exerts Influences on Host Immune Functions via Host Cytokine Receptor Complexes.

PIMMS (Pragmatic Insertional Mutation Mapping System) laboratory methodology a readily accessible tool for identification of essential genes in Streptococcus (2016)
Journal Article
Blanchard, A. M., Egan, S. A., Emes, R. D., Warry, A., & Leigh, J. A. (2016). PIMMS (Pragmatic Insertional Mutation Mapping System) laboratory methodology a readily accessible tool for identification of essential genes in Streptococcus. Frontiers in Microbiology, 7(1645), https://doi.org/10.3389/fmicb.2016.01645

The Pragmatic Insertional Mutation Mapping (PIMMS) laboratory protocol was developed alongside various bioinformatics packages (Blanchard et al., 2015) to enable detection of essential and conditionally essential genes in Streptococcus and related ba... Read More about PIMMS (Pragmatic Insertional Mutation Mapping System) laboratory methodology a readily accessible tool for identification of essential genes in Streptococcus.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Sulak, M., Fong, L., Mika, K., Chigurupati, S., Yon, L., Mongan, N. P., …Lynch, V. J. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5(2016), Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants (2016)
Journal Article
Michael, S., Lindsey, F., Katelyn, M., Sravanthi, C., Lisa, Y., Nigel P, M., …Vincent J, L. (2016). TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants. eLife, 5, Article e11994. https://doi.org/10.7554/eLife.11994.001

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here... Read More about TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants.

Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals (2016)
Journal Article
Naqid, I. A., Owen, J. P., Maddison, B. C., Spiliotopoulos, A., Emes, R. D., Warry, A., …Gough, K. C. (2016). Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals. Scientific Reports, 6, Article 31186. https://doi.org/10.1038/srep31186

Serological surveillance and vaccination are important strategies for controlling infectious diseases of food production animals. However, the compatibility of these strategies is limited by a lack of assays capable of di erentiating infected from va... Read More about Mapping B-cell responses to Salmonella enterica serovars Typhimurium and Enteritidis in chickens for the discrimination of infected from vaccinated animals.

RNA expression of TLR10 in normal equine tissues (2016)
Journal Article
Tarlinton, R. E., Alder, L., Moreton, J., Maboni, G., Emes, R. D., & Tötemeyer, S. (2016). RNA expression of TLR10 in normal equine tissues. BMC Research Notes, 9, Article 353. https://doi.org/10.1186/s13104-016-2161-9

Background: Toll like receptors are one of the major innate immune system pathogen recognition systems. There is little data on the expression of the TLR10 member of this family in the horse. Results: This paper describes the genetic structure of... Read More about RNA expression of TLR10 in normal equine tissues.

Analysis of mitochondrial haemoglobin in Parkinson's disease brain (2016)
Journal Article
Shephard, F., Greville-Heygate, O., Liddell, S., Emes, R. D., & Chakrabarti, L. (2016). Analysis of mitochondrial haemoglobin in Parkinson's disease brain. Mitochondrion, 29, 45-52. https://doi.org/10.1016/j.mito.2016.05.001

Mitochondrial dysfunction is an early feature of neurodegeneration. We have shown there are mitochondrial haemoglobin changes with age and neurodegeneration. We hypothesised that altered physiological processes are associated with recruitment and loc... Read More about Analysis of mitochondrial haemoglobin in Parkinson's disease brain.

Mapping polyclonal antibody responses to bacterial infection using next generation phage display (2016)
Journal Article
Naqid, I. A., Owen, J. P., Maddison, B. C., Spiliotopoulos, A., Emes, R. D., Warry, A., …Gough, K. C. (2016). Mapping polyclonal antibody responses to bacterial infection using next generation phage display. Scientific Reports, 6, Article 24232. https://doi.org/10.1038/srep24232

Mapping polyclonal antibody responses to infectious diseases to identify individual epitopes has the potential to underpin the development of novel serological assays and vaccines. Here, phage-peptide library panning coupled with screening using next... Read More about Mapping polyclonal antibody responses to bacterial infection using next generation phage display.

Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer (2016)
Journal Article
Kitchen, M. O., Bryan, R. T., Emes, R. D., Glossop, J. R., Luscombe, C., Cheng, K. K., …Farrell, W. E. (2016). Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer. Epigenetics, 11(3), 237-246. https://doi.org/10.1080/15592294.2016.1154246

High-grade non-muscle invasive bladder cancer (HG-NMIBC) is a clinically unpredictable disease with greater risks of recurrence and progression relative to their low-intermediate-grade counterparts. The molecular events, including those affecting the... Read More about Quantitative genome-wide methylation analysis of high-grade non-muscle invasive bladder cancer.

Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes (2016)
Journal Article
Moreton, J., Izquierdo, A., & Emes, R. D. (2016). Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes. Frontiers in Genetics, 6, Article 361. https://doi.org/10.3389/fgene.2015.00361

De novo assembly of a complete transcriptome without the need for a guiding reference genome is attractive, particularly where the cost and complexity of generating a eukaryote genome is prohibitive. The transcriptome should not however be seen as ju... Read More about Assembly, Assessment, and Availability of De novo Generated Eukaryotic Transcriptomes.