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All Outputs (9)

Multiple groups of endogenous epsilon-like retroviruses conserved across primates (2014)
Journal Article
Brown, K., Emes, R. D., & Tarlinton, R. E. (2014). Multiple groups of endogenous epsilon-like retroviruses conserved across primates. Journal of Virology, 88(21), https://doi.org/10.1128/JVI.00966-14

Several types of cancer in fish are caused by retroviruses, including those responsible for major outbreaks of disease, such as walleye dermal sarcoma virus and salmon swim bladder sarcoma virus. These viruses form a phylogenetic group often describe... Read More about Multiple groups of endogenous epsilon-like retroviruses conserved across primates.

The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits (2014)
Journal Article
Parameswaran, N., Haig, D., Dewals, B. G., Giles, T. C., Deppmann, C., Blythe, M., …Emes, R. D. (2014). The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits. Virus Research, 188, 68-80. https://doi.org/10.1016/j.virusres.2014.04.003

Alcelaphine herpesvirus-1 (AlHV-1) causes malignant catarrhal fever (MCF). The A2 gene of AlHV-1 is a member of the bZIP transcription factor family. We wished to determine whether A2 is a virulence gene or not and whether it is involved in pathogene... Read More about The A2 gene of alcelaphine herpesvirus-1 is a transcriptional regulator affecting cytotoxicity in virus-infected T cells but is not required for malignant catarrhal fever induction in rabbits.

Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. (2014)
Journal Article
Glossop, J. R., Emes, R., Nixon, N. B., Haworth, K. E., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2014). Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations. Epigenetics, 9(9), 1228-1237. https://doi.org/10.4161/epi.29718

Changes to the DNA methylome have been described in patients with rheumatoid arthritis (RA). In previous work, we reported genome-wide methylation differences in T-lymphocyte and B-lymphocyte populations from healthy individuals. Now, using HumanMeth... Read More about Genome-wide DNA methylation profiling in rheumatoid arthritis identifies disease-associated methylation changes that are distinct to individual T- and B-lymphocyte populations..

A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome (2014)
Journal Article
Moreton, J., Dunham, S. P., & Emes, R. D. (2014). A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome. Frontiers in Genetics, 5, Article 190. https://doi.org/10.3389/fgene.2014.00190

For vertebrate organisms where a reference genome is not available, de novo transcriptome assembly enables a cost effective insight into the identification of tissue specific or differentially expressed genes and variation of the coding part of the g... Read More about A consensus approach to vertebrate de novo transcriptome assembly from RNA-seq data: assembly of the duck (Anas platyrhynchos) transcriptome.

Characterisation of the horse transcriptome from immunologically active tissues (2014)
Journal Article
Moreton, J., Malla, S., Aboobaker, A., Tarlinton, R. E., & Emes, R. D. (2014). Characterisation of the horse transcriptome from immunologically active tissues. PeerJ, 2, Article e382. https://doi.org/10.7717/peerj.382

The immune system of the horse has not been well studied, despite the fact that the horse displays several features such as sensitivity to bacterial lipopolysaccharide that make them in many ways a more suitable model of some human disorders than the... Read More about Characterisation of the horse transcriptome from immunologically active tissues.

Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana) (2014)
Journal Article
Nilsson, E. M., Fainberg, H. P., Choong, S. S., Giles, T. C., Sells, J., May, S., …Yon, L. (2014). Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana). PLoS ONE, 9(3), Article e91717. https://doi.org/10.1371/journal.pone.0091717

Adipose tissue (AT) is a dynamic and flexible organ with regulatory roles in physiological functions including metabolism, reproduction and inflammation; secreted adipokines, including leptin, and fatty acids facilitate many of these roles. The Afric... Read More about Molecular Characterization of Adipose Tissue in the African Elephant (Loxodonta africana).

Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions (2014)
Journal Article
Haig, D., Smith, S., & Emes, R. (2014). Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions. Gene, 540(2), 217-225. https://doi.org/10.1016/j.gene.2014.02.032

Toll-like receptors initiate inflammatory responses following the recognition of a wide repertoire of pathogens including bacteria, fungi, protozoa and viruses. They are composed of an extracellular leucine-rich repeat domain responsible for detectin... Read More about Novel ovine polymorphisms and adaptive evolution in mammalian TLR2 suggest existence of multiple pathogen binding regions.

Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects (2014)
Journal Article
Onoufriadis, A., Shoemark, A., Schmidts, M., Patel, M., Jimenez, G., Liu, H., …Mitchison, H. M. (2014). Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects. Human Molecular Genetics, 23(13), 3362-3374. https://doi.org/10.1093/hmg/ddu046

Primary ciliary dyskinesia (PCD) is an inherited chronic respiratory obstructive disease with randomized body laterality and infertility, resulting from cilia and sperm dysmotility. PCD is characterized by clinical variability and extensive genetic h... Read More about Targeted NGS gene panel identifies mutations in RSPH1 causing primary ciliary dyskinesia and a common mechanism for ciliary central pair agenesis due to radial spoke defects.