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Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription (2019)
Journal Article
Utt, A., Rausalu, K., Jakobson, M., Männik, A., Alphey, L., Fragkoudis, R., & Merits, A. (2019). Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription. Journal of Virology, 93(18), Article e00794-19. https://doi.org/10.1128/jvi.00794-19

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. It has a positive sense RNA genome that also serves as the mRNA for four non-structural proteins (nsPs) representing subunits of the viral replicase. Coupling of nsP and RNA synthesis complica... Read More about Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription.

Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life (2018)
Journal Article
Fragkoudis, R., Dixon-Ballany, C., Zagrajek, A., Kedzierski, L., & Fazakerley, J. (2018). Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life. Viruses, 10(5), Article 273. https://doi.org/10.3390/v10050273

Alphaviruses are mosquito-transmitted RNA viruses which generally cause acute disease including mild febrile illness, rash, arthralgia, myalgia and more severely, encephalitis. In the mouse, peripheral infection with Semliki Forest virus (SFV) result... Read More about Following acute encephalitis, Semliki Forest virus is undetectable in the brain by infectivity assays but functional virus RNA capable of generating infectious virus persists for life.