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A lexicon of DNA modifications: their roles in embryo development and the germline (2018)
Journal Article
Zhu, Q., Stöger, R., & Alberio, R. (2018). A lexicon of DNA modifications: their roles in embryo development and the germline. Frontiers in Cell and Developmental Biology, 6, doi:10.3389/fcell.2018.00024

5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are t... Read More

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells (2017)
Journal Article
Choi, M., Genereux, D. P., Goodson, J., Al-Azzawi, H., Allain, S. Q., Simon, N., …Laird, C. D. (2017). Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells. PLoS Genetics, 13(11), doi:10.1371/journal.pgen.1007060

In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encode... Read More

Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease (2017)
Journal Article
Tarale, P., Daiwile, A. P., Sivanesan, S., Stöger, R., Bafana, A., Naoghare, P. K., …Krishnamurthi, K. (2018). Manganese exposure: linking down-regulation of miRNA-7 and miRNA-433 with α-synuclein overexpression and risk of idiopathic Parkinson's disease. Toxicology in Vitro, 46, doi:10.1016/j.tiv.2017.10.003

Manganese is an essential trace element however elevated environmental and occupational exposure to this element has been correlated with neurotoxicity symptoms clinically identical to idiopathic Parkinson's disease. In the present study we chronical... Read More

High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas (2017)
Journal Article
Nica, D., Popescu, C., Draghici, G., Andrica, F., Privistirescu, I., Gergen, I. I., & Stöger, R. (2017). High-level dietary cadmium exposure is associated with global DNA hypermethylation in the gastropod hepatopancreas. PLoS ONE, 12(9), doi:10.1371/journal.pone.0184221

5-methylcytosine (5mC) is a key epigenetic mark which influences gene expression and phenotype. In vertebrates, this epigenetic mark is sensitive to Cd exposure, but there is no information linking such an event with changes in global 5mC levels in t... Read More

Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas (2017)
Journal Article
Nica, D., Popescu, C., Draghici, G., Privistirescu, I., Suciu, M., & Stöger, R. (2017). Effect of cadmium on cytosine hydroxymethylation in gastropod hepatopancreas. Environmental Science and Pollution Research, 24(17), doi:10.1007/s11356-017-9104-4

5-Hydroxymethylcytosine (5hmC) is an important, yet poorly understood epigenetic DNA modification, especially in invertebrates. Aberrant genome-wide 5hmC levels have been associated with cadmium (Cd) exposure in humans, but such information is lackin... Read More

Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes (2016)
Journal Article
Tarale, P., Sivanesan, S., Daiwile, A. P., Stöger, R., Bafana, A., Naoghare, P. K., …Kannan, K. (in press). Global DNA methylation profiling of manganese-exposed human neuroblastoma SH-SY5Y cells reveals epigenetic alterations in Parkinson’s disease-associated genes. Archives of Toxicology, doi:10.1007/s00204-016-1899-0

Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulti... Read More