Research Repository

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The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response (2018)
Journal Article
Barone, G., Arora, A., Ganesh, A., Abdel-Fatah, T., Moseley, P., Ali, R., …Collis, S. J. (2018). The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response. Oncotarget, 9, (29508-29524). doi:10.18632/oncotarget.25686. ISSN 1949-2553

Background: Cyclin-Dependent Kinases (CDKs) are established anti-cancer drug targets and a new generation of CDK inhibitors are providing clinical benefits to a sub-set of breast cancer patients. We have recently shown that human CDK18 promotes effic... Read More

Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers (2017)
Journal Article
Green, A. R., Aleskandarany, M. A., Ali, R., Hodgson, E. G., Atabani, S., De Souza, K., …Madhusudan, S. (2017). Clinical impact of tumor DNA repair expression and T-cell infiltration in breast cancers. Cancer Immunology Research, 5(4), doi:10.1158/2326-6066.CIR-16-0195

Impaired DNA repair drives mutagenicity, which increases neoantigen load and immunogenicity. We investigated the expression of proteins involved in the DNA damage response (ATM, Chk2), double-strand break repair (BRCA1, BLM, WRN, RECQL4, RECQL5, TOPO... Read More

DNA damage repair in breast cancer and its therapeutic implications (2016)
Journal Article
Ali, R., Rakha, E. A., Madhusudan, S., & Bryant, H. E. (2017). DNA damage repair in breast cancer and its therapeutic implications. Pathology, 49(2), 156-165. doi:10.1016/j.pathol.2016.11.002

The DNA damage response (DDR) involves the activation of numerous cellular activities that repair DNA lesions and maintain genomic integrity, and is critical in preventing tumorigenesis. Inherited or acquired mutations in specific genes involved in t... Read More

Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers (2016)
Journal Article
Arora, A., Parvathaneni, S., Aleskandarany, M. A., Agarwal, D., Ali, R., Abdel-Fatah, T., …Madhusudan, S. (2017). Clinicopathological and functional significance of RECQL1 helicase in sporadic breast cancers. Molecular Cancer Therapeutics, 16(1), doi:10.1158/1535-7163.MCT-16-0290

RECQL1, a key member of the RecQ family of DNA helicases, is required for DNA replication and DNA repair. Two recent studies have shown that germline RECQL1 mutations are associated with increased breast cancer susceptibility. Whether altered RECQL1... Read More

The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments (2016)
Journal Article
Hu, A., Chen, C., Mantle, M. D., Wolf, B., Gladden, L. F., Rajabi-Siahboomi, A., …Melia, C. D. (2017). The properties of HPMC: PEO extended release hydrophilic matrices and their response to ionic environments. Pharmaceutical Research, 34(5), doi:10.1007/s11095-016-2031-0. ISSN 0724-8741

Purpose Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths. Methods The extended release behaviour of various HPMC:PEO compacts was investigate... Read More

Myths and legends: the reality of rape offences reported to a UK police force (2016)
Journal Article
Waterhouse, G. F., Reynolds, A., & Egan, V. (2016). Myths and legends: the reality of rape offences reported to a UK police force. European Journal of Psychology Applied to Legal Context, 8(1), doi:10.1016/j.ejpal.2015.04.001. ISSN 1889-1861

Rape myths affect many aspects of the investigative and criminal justice systems. One such myth, the‘real rape’ myth, states that most rapes involve a stranger using a weapon attacking a woman violently atnight in an isolated, outdoor area, and that... Read More

The impact of porous media heterogeneity on non-Darcy flow behaviour from pore-scale simulation (2015)
Journal Article
Muljadi, B. P., Blunt, M. J., Raeini, A. Q., & Bijeljic, B. (2016). The impact of porous media heterogeneity on non-Darcy flow behaviour from pore-scale simulation. Advances in Water Resources, 95, doi:10.1016/j.advwatres.2015.05.019. ISSN 0309-1708

The effect of pore-scale heterogeneity on non-Darcy flow behaviour is investigated by means of direct flow simulations on 3-D images of a beadpack, Bentheimer sandstone and Estaillades carbonate. The critical Reynolds number indicating the cessation... Read More