Research Repository

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Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology (2018)
Journal Article
Ivell, R., & Anand-Ivell, R. (2018). Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology. Human Reproduction Update, 24(6), (639-651). doi:10.1093/humupd/dmy029. ISSN 1355-4786

BACKGROUND Insulin-like peptide 3 (INSL3) is a member of the relaxin family of neohormones which has evolved to address specifically mammalian aspects of reproduction related to viviparity and internal fertilization. It was originally identified as... Read More

Testicular function and bone in young men with severe childhood-onset obesity. (2018)
Journal Article
Anand-Ivell, R., Ivell, R., Laakso, S., Viljakainen, H., Lipsanen-Nyman, M., Turpeinen, U., …Mäkitie, O. (2018). Testicular function and bone in young men with severe childhood-onset obesity. Hormone Research in Paediatrics, 89(6), (442–449). doi:10.1159/000489818. ISSN 1663-2818

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puber... Read More

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum (2018)
Journal Article
Anand-Ivell, R., Juul, A., & Albrethsen, J. (2018). Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum. Clinical Chemistry and Laboratory Medicine, 56(11), doi:10.1515/cclm-2018-0171

BACKGROUND: The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker reflecting Leydig cell function in the male. Few commercial immunoassays of varying quality exist. Therefore, we decided to devel... Read More

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, doi:10.3389/fphys.2017.01033. ISSN 1664-042X

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More

Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus (2017)
Journal Article
Glynn, D. J., Heng, K., Russell, D. L., Sharkey, D. J., Robertson, S. A., Anand-Ivell, R., & Ivell, R. (2017). Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus. Frontiers in Physiology, 8, doi:10.3389/fphys.2017.00422. ISSN 1664-042X

The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract. We hypothesized that relaxin might be one comp... Read More

Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine (2017)
Journal Article
Dai, Y., Ivell, R., Liu, X., Janowski, D., & Anand-Ivell, R. (2017). Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine. Frontiers in Physiology, 8, doi:10.3389/fphys.2017.00359. ISSN 1664-042X

In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep. While, these ruminants appear to... Read More

Relaxin-like peptides in male reproduction: a human perspective (2017)
Journal Article
Ivell, R., Agoulnik, A. I., & Anand-Ivell, R. (2017). Relaxin-like peptides in male reproduction: a human perspective. British Journal of Pharmacology, 174(10), doi:10.1111/bph.13689. ISSN 0007-1188

The relaxin family of peptide hormones and their cognate GPCRs are becoming physiologically well-characterized in the cardiovascular system and particularly in female reproductive processes. Much less is known about the physiology and pharmacology of... Read More

The male fetal biomarker INSL3 reveals substantial hormone exchange between fetuses in early pig gestation (2016)
Journal Article
Vernunft, A., Ivell, R., Heng, K., & Anand-Ivell, R. (2016). The male fetal biomarker INSL3 reveals substantial hormone exchange between fetuses in early pig gestation. PLoS ONE, 11(3), doi:10.1371/journal.pone.0152689. ISSN 1932-6203

The peptide hormone INSL3 is uniquely produced by the fetal testis to promote the transabdominal phase of testicular descent. Because it is fetal sex specific, and is present in only very low amounts in the maternal circulation, INSL3 acts as an idea... Read More

Longitudinal assessment of circulating insulin-like peptide 3 levels in healthy peripubertal girls (2014)
Journal Article
Hagen, C. P., Mieritz, M. G., Nielsen, J. E., Anand-Ivell, R., Ivell, R., & Juul, A. (2015). Longitudinal assessment of circulating insulin-like peptide 3 levels in healthy peripubertal girls. Fertility and Sterility, 103(3), doi:10.1016/j.fertnstert.2014.11.014. ISSN 0015-0282

Objective: To elucidate the natural course of circulating insulin-like peptide 3 (INSL3) levels according to puberty as well as its relation to other reproductive hormones. Design: Population-based cohort study. Setting: Not applicable. Patient(s)... Read More

Insulin-like factor 3 and the HPG axis in the male (2014)
Journal Article
Ivell, R., Heng, K., & Anand-Ivell, R. (in press). Insulin-like factor 3 and the HPG axis in the male. Frontiers in Endocrinology, 5(6), doi:10.3389/fendo.2014.00006. ISSN 1664-2392

The hypothalamic–pituitary–gonadal (HPG) axis comprises pulsatile GnRH from the hypothalamus impacting on the anterior pituitary to induce expression and release of both LH and FSH into the circulation. These in turn stimulate receptors on testicular... Read More

Insulin-like factor 3 as a monitor of endocrine disruption (2013)
Journal Article
Anand-Ivell, R., & Ivell, R. (2014). Insulin-like factor 3 as a monitor of endocrine disruption. Reproduction, 147, doi:10.1530/REP-13-0486. ISSN 1470-1626

Insulin-like factor 3 (INSL3) is generated and secreted by differentiated interstitial Leydig cells of the testes in both fetal and adult males of all mammalian species so far analyzed. All evidence to date suggests that it is produced constitutively... Read More

Circulating insulin-like factor 3 (INSL3) in healthy and infertile women (2013)
Journal Article
Anand-Ivell, R., Tremellen, K., Dai, Y., Heng, K., Yosida, M., Knight, P., & Ivell, R. (2013). Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. Human Reproduction, 28(11), doi:10.1093/humrep/det3. ISSN 0268-1161

Study question: How does insulin-like factor 3 (INSL3) concentration in blood vary across the menstrual cycle in women? Summary answer: INSL3 is secreted by the theca interna cells of growing antral follicles and is phasic in its expression. What i... Read More

Regulation of the reproductive cycle and early pregnancy by relaxin family peptides (2013)
Journal Article
Anand-Ivell, R., & Ivell, R. (2014). Regulation of the reproductive cycle and early pregnancy by relaxin family peptides. Molecular and Cellular Endocrinology, 382(1), doi:10.1016/j.mce.2013.08.010. ISSN 0303-7207

The relaxin family of peptide hormones are structurally closely related to one another sharing a heterodimeric A–B structure, like that of insulin. They may also be active as unprocessed B–C–A pro-forms. Relaxin has been shown to pay a key role withi... Read More