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All Outputs (6)

Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle (2017)
Journal Article
Dai, Y., Ivell, R., & Anand-Ivell, R. (2017). Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle. Frontiers in Physiology, 8, https://doi.org/10.3389/fphys.2017.01033

Insulin-like peptide 3 (INSL3) and its specific receptor RXFP2 are both expressed by theca interna cells of the growing antral follicle where they form an essential regulatory element in the production of the steroid precursor androstenedione. Using... Read More about Theca cell INSL3 and steroids together orchestrate the growing bovine antral follicle.

Neohormones in milk (2017)
Journal Article
Ivell, R., & Anand-Ivell, R. (2017). Neohormones in milk. Best Practice and Research: Clinical Endocrinology and Metabolism, 31(4), https://doi.org/10.1016/j.beem.2017.10.005

Neohormone systems evolved specifically to regulate those mammalian traits, such as internal fertilization, pregnancy and lactation, which have proved to be central to the success, environmental independence, and adaptability of mammals as a vertebra... Read More about Neohormones in milk.

Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus (2017)
Journal Article
Glynn, D. J., Heng, K., Russell, D. L., Sharkey, D. J., Robertson, S. A., Anand-Ivell, R., & Ivell, R. (2017). Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus. Frontiers in Physiology, 8, Article 422. https://doi.org/10.3389/fphys.2017.00422

The hormone relaxin is important in female reproduction for embryo implantation, cardiovascular function, and during labor and lactation. Relaxin is also synthesized in males by organs of the male tract. We hypothesized that relaxin might be one comp... Read More about Male seminal relaxin contributes to induction of the post-mating cytokine response in the female mouse uterus.

Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine (2017)
Journal Article
Dai, Y., Ivell, R., Liu, X., Janowski, D., & Anand-Ivell, R. (2017). Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine. Frontiers in Physiology, 8, Article 359. https://doi.org/10.3389/fphys.2017.00359

In most mammals the peptide hormone relaxin is a key physiological component regulating early pregnancy and birth. However, synteny analysis shows that the gene encoding ovarian relaxin-2 is deleted in cows and sheep. While, these ruminants appear to... Read More about Relaxin-family peptide receptors 1 and 2 are fully functional in the bovine.

Relaxin-like peptides in male reproduction: a human perspective (2017)
Journal Article
Ivell, R., Agoulnik, A. I., & Anand-Ivell, R. (2017). Relaxin-like peptides in male reproduction: a human perspective. British Journal of Pharmacology, 174(10), 990-1001. https://doi.org/10.1111/bph.13689

The relaxin family of peptide hormones and their cognate GPCRs are becoming physiologically well-characterized in the cardiovascular system and particularly in female reproductive processes. Much less is known about the physiology and pharmacology of... Read More about Relaxin-like peptides in male reproduction: a human perspective.

Endocrinology of the Fetal Testis (2017)
Book Chapter
Ivell, R., Anand-Ivell, R., & Morley, S. D. (2017). Endocrinology of the Fetal Testis. In M. Simoni, & I. Huhtaniemi (Eds.), Endocrinology of the Testis and Male Reproduction (245-272). Springer. https://doi.org/10.1007/978-3-319-44441-3_7

The human fetus, already at a very early stage in its development, is hormonally active, with the testis and adrenal gland being major contributors. Following sex determination at around weeks 5–6, the somatic cells of the testis begin to differentia... Read More about Endocrinology of the Fetal Testis.