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Regulation of Cell Fate Decisions in Early Mammalian Embryos (2019)
Journal Article
Alberio, R. (2020). Regulation of Cell Fate Decisions in Early Mammalian Embryos. Annual Review of Animal Biosciences, 8(1), 377-393. https://doi.org/10.1146/annurev-animal-021419-083841

Early embryogenesis is characterized by the segregation of cell lineages that fulfill critical roles in the establishment of pregnancy and development of the fetus. The formation of the blastocyst marks the emergence of extraembryonic precursors, nee... Read More about Regulation of Cell Fate Decisions in Early Mammalian Embryos.

A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos (2019)
Journal Article
Canizo, J. R., Ynsaurralde Rivolta, A. E., Vazquez Echegaray, C., Suvá, M., Alberio, V., Aller, J. F., …Alberio, R. (2019). A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos. BMC Developmental Biology, 19(1), 1-13. https://doi.org/10.1186/s12861-019-0193-9

Background The segregation of the hypoblast and the emergence of the pluripotent epiblast mark the final stages of blastocyst formation in mammalian embryos. In bovine embryos the formation of the hypoblast has been partially studied, and evidence s... Read More about A dose-dependent response to MEK inhibition determines hypoblast fate in bovine embryos.

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis (2019)
Journal Article
Ramos-Ibeas, P., Sang, F., Zhu, Q., Wang, W. W., Withey, S., Klisch, D., …Alberio, R. (2019). Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis. Nature Communications, 10, https://doi.org/10.1038/s41467-019-08387-8

High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-implantation stages, since early post-implantation embryos are largely ina... Read More about Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis.