All Outputs (7)

Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis (2019)
Journal Article
Ramos-Ibeas, P., Sang, F., Zhu, Q., Wang, W. W., Withey, S., Klisch, D., …Alberio, R. (2019). Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis. Nature Communications, 10, https://doi.org/10.1038/s41467-019-08387-8

High-resolution molecular programmes delineating the cellular foundations of mammalian embryogenesis have emerged recently. Similar analysis of human embryos is limited to pre-implantation stages, since early post-implantation embryos are largely ina... Read More about Pluripotency and X chromosome dynamics revealed in pig pre-gastrulating embryos by single cell analysis.

A lexicon of DNA modifications: their roles in embryo development and the germline (2018)
Journal Article
Zhu, Q., Stöger, R., & Alberio, R. (2018). A lexicon of DNA modifications: their roles in embryo development and the germline. Frontiers in Cell and Developmental Biology, 6, Article 24. https://doi.org/10.3389/fcell.2018.00024

5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes. Many of these modifications are t... Read More about A lexicon of DNA modifications: their roles in embryo development and the germline.

Transcriptional and epigenetic control of cell fate decisions in early embryos (2017)
Journal Article
Alberio, R. (2017). Transcriptional and epigenetic control of cell fate decisions in early embryos. Reproduction, Fertility and Development, 30(1), https://doi.org/10.1071/RD17403

Mammalian embryo development is characterized by regulative mechanisms of lineage segregation and cell specification. A combination of carefully orchestrated gene expression networks, signalling pathways and epigenetic marks define specific developme... Read More about Transcriptional and epigenetic control of cell fate decisions in early embryos.

Primordial germ cells: the first cell lineage or the last cells standing? (2015)
Journal Article
Johnson, A. D., & Alberio, R. (in press). Primordial germ cells: the first cell lineage or the last cells standing?. Development, 142, https://doi.org/10.1242/dev.113993

Embryos of many animal models express germ line determinants that suppress transcription and mediate early germ line commitment, which occurs before the somatic cell lineages are established. However, not all animals segregate their germ line in this... Read More about Primordial germ cells: the first cell lineage or the last cells standing?.

Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes (2015)
Journal Article
German, S. D., Lee, J., Campbell, K. H., Sweetman, D., & Alberio, R. (in press). Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes. Biology of Reproduction, 92(4), https://doi.org/10.1095/biolreprod.114.122341

Oocytes treated with the protein synthesis inhibitor cycloheximide (CHX) arrest at the germinal vesicle (GV) stage and undergo accelerated GV breakdown (GVBD) after CHX is removed. However, little is known about the underlying mechanism of accelerate... Read More about Actin depolymerization is associated with meiotic acceleration in cycloheximide-treated ovine oocytes.

Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation (2014)
Journal Article
Valdez Magaña, G., Rodríguez, A., Zhang, H., Webb, R., & Alberio, R. (2014). Paracrine effects of embryo-derived FGF4 and BMP4 during pig trophoblast elongation. Developmental Biology, 387(1), 15-27. https://doi.org/10.1016/j.ydbio.2014.01.008

Modulation of pluripotency in the porcine embryo and iPS Cells (2012)
Journal Article
Rodríguez, A., Allegrucci, C., & Alberio, R. (2012). Modulation of pluripotency in the porcine embryo and iPS Cells. PLoS ONE, 7(11), Article 12. https://doi.org/10.1371/journal.pone.0049079

The establishment of the pluripotent ICM during early mammalian development is characterized by the differential expression of the transcription factors NANOG and GATA4/6, indicative of the epiblast and hypoblast, respectively. Differences in the mec... Read More about Modulation of pluripotency in the porcine embryo and iPS Cells.