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Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor (2017)
Journal Article
Weitsman, G., Mitchell, N. J., Evans, R., Cheung, A., Kalber, T. L., Bofinger, R., …Ng, T. (in press). Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor. Oncogene, doi:10.1038/onc.2016.522. ISSN 0950-9232

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the im... Read More

RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers (2017)
Journal Article
Irshad, S., Flores-Borja, F., Lawler, K., Monypenny, J., Evans, R., Male, V., …Martin, S. G. (2017). RORγt+ innate lymphoid cells promote lymph node metastasis of breast cancers. Cancer Research, 77(5), doi:10.1158/0008-5472.CAN-16-0598

Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the... Read More