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The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma (2017)
Presentation / Conference
Kaczmarek, K. A., Clifford, R. L., Patel, J. K., Shaw, D., Dowden, J., & Knox, A. J. (2017, May). The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma. Poster presented at American Thoracic Society 2017 International Conference

Introduction and objectives: Asthma is estimated to affect at least 300 million people globally. About 25% of the patients do not respond to therapy; therefore we need to develop novel treatments. ASM cells have a crucial role in asthma, contributin... Read More

Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors (2016)
Journal Article
Clifford, R. L., Patel, J., Shaw, D., Knox, A., & Kobor, M. (in press). Investigating genome wide dna methylation in airway smooth muscle cells from asthmatic and non-asthmatic donors. Thorax, 71(Suppl3), doi:10.1136/thoraxjnl-2016-209333.381. ISSN 0040-6376

Rationale: Genetic mechanisms fail to fully explain asthma pathogenesis and environmental factors are considered to play an important role. Environmental factors may lead to permanent changes in epigenetic patterns and contribute to asthma. Epigeneti... Read More

The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma (2016)
Journal Article
Kaczmarek, K., Clifford, R. L., Patel, J., Shaw, D., Dowden, J., & Knox, A. (2016). The role of histone arginine methylation in gene expression of airway smooth muscle cells in asthma. Thorax, 71(Suppl3), A214-A215. doi:10.1136/thoraxjnl-2016-209333.379

Introduction and objectives: Asthma is estimated to affect at least 300 million people globally. About 25% of the patients do not respond to therapy; therefore we need to develop novel treatments. ASM cells have a crucial role in asthma, contributing... Read More

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells (2016)
Journal Article
Poghosyan, A., Patel, J. K., Clifford, R. L., & Knox, A. J. (2016). Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells. Biochemical and Biophysical Research Communications, 476(4), doi:10.1016/j.bbrc.2016.05.140. ISSN 0006-291X

Airway epithelial cells in cystic fibrosis (CF) overexpress Interleukin 8 (CXCL8) through poorly defined mechanisms. CXCL8 transcription is dependent on coordinated binding of CCAAT/enhancer binding protein (C/EBP)β, nuclear factor (NF)-κB, and activ... Read More

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation (2016)
Journal Article
Clifford, R. L., Jones, M. J., MacIsaac, J. L., McEwen, L. M., Goodman, S. J., Mostafavi, S., …Carlsten, C. (2017). Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylation. Journal of Allergy and Clinical Immunology, 139(1), doi:10.1016/j.jaci.2016.03.046. ISSN 0091-6749

Background Allergic disease affects 30% to 40% of the world's population, and its development is determined by the interplay between environmental and inherited factors. Air pollution, primarily consisting of diesel exhaust emissions, has increase... Read More