Research Repository

See what's under the surface


NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy (2017)
Journal Article
Rossi, F., Geiszler, P. C., Meng, W., Barron, M., Prior, M., Herd-Smith, A., …Conforti, L. (2018). NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy. Behavioural Brain Research, 339, doi:10.1016/j.bbr.2017.11.030. ISSN 0166-4328

NAD metabolism and the NAD biosynthetic enzymes nicotinamide nucleotide adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in tauopathies, including Alzheimer’s disease. Here, we investigated whether modulating the expressio... Read More

A novel role for the immunophilin FKBP52 in motor coordination (2016)
Journal Article
Young, M. J., Geiszler, P. C., & Pardon, M. (in press). A novel role for the immunophilin FKBP52 in motor coordination. Behavioural Brain Research, 313, doi:10.1016/j.bbr.2016.07.015. ISSN 0166-4328

FKBP52 is a ubiquitously distributed immunophilin that has been associated with wideranging functions in cell signalling as well as hormonal and stress responses. Amongst other pathways, it acts via complex-formation with corticosteroid receptors and... Read More

Impaired burrowing is the most prominent behavioral deficit of aging htau mice (2016)
Journal Article
Geiszler, P. C., Barron, M., & Pardon, M. (in press). Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience, doi:10.1016/j.neuroscience.2016.05.004. ISSN 0306-4522

htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer's disease. Whilst histopathological changes in htau mice have been researched in t... Read More