All Outputs (5)

The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project (2024)
Journal Article
Jefferson, E., Milligan, G., Johnston, J., Mumtaz, S., Cole, C., Best, J., Giles, T. C., Cox, S., Masood, E., Horban, S., Urwin, E., Beggs, J., Chuter, A., Reilly, G., Morris, A., Seymour, D., Hopkins, S., Sheikh, A., & Quinlan, P. (2024). The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project. Journal of Medical Internet Research, 26, Article e50235. https://doi.org/10.2196/50235

The COVID-19-Curated and Open Analysis and Research Platform (CO-CONNECT) project worked with 22 organizations across the United Kingdom to build a federated platform, enabling researchers to instantaneously and dynamically query federated datasets t... Read More about The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project.

Lessons from the PROTECT-CH COVID-19 platform trial in care homes (2024)
Journal Article
Bath, P. M., Ball, J., Boyd, M., Gage, H., Glover, M., Godfrey, M., Guthrie, B., Hewitt, J., Howard, R., Jaki, T., Juszczak, E., Lasserson, D., Leighton, P., Leyland, V., Shen Lim, W., Logan, P., Meakin, G., Montgomery, A., Ogollah, R., Passmore, P., …Gordon, A. L. (in press). Lessons from the PROTECT-CH COVID-19 platform trial in care homes. Health Technology Assessment,

A SARS-CoV-2 minimum data standard to support national serology reporting (2024)
Journal Article
Urwin, E. N., Martin, J., Sebire, N., Harris, A., Johnson, J., Masood, E., Milligan, G., Mairs, L., Chuter, A., Ferguson, M., Quinlan, P., & Jefferson, E. (2024). A SARS-CoV-2 minimum data standard to support national serology reporting. Annals of Clinical Biochemistry, 61(6), 418-445. https://doi.org/10.1177/00045632241261274

Background: Healthcare laboratory systems produce and capture a vast array of information, yet do not always report all of this to the national infrastructure within the United Kingdom. The global COVID-19 pandemic brought about a much greater need f... Read More about A SARS-CoV-2 minimum data standard to support national serology reporting.

Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease (2022)
Journal Article
Gonem, S., Taylor, A., Figueredo, G., Forster, S., Quinlan, P., Garibaldi, J. M., McKeever, T. M., & Shaw, D. (2022). Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease. Respiratory Research, 23, Article 203. https://doi.org/10.1186/s12931-022-02130-6

Background: The National Early Warning Score-2 (NEWS-2) is used to detect patient deterioration in UK hospitals but fails to take account of the detailed granularity or temporal trends in clinical observations. We used data-driven methods to develop... Read More about Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease.

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation (2020)
Journal Article
Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., …Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11, Article 5156. https://doi.org/10.1038/s41467-020-18973-w

The most frequent genetic alterations across multiple human cancers are mutations in TP53 and the activation of the PI3K/AKT pathway, two events crucial for cancer progression. Mutations in TP53 lead to the inhibition of the tumour and metastasis sup... Read More about Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.