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All Outputs (199)

Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future (2020)
Journal Article
Mok, V. C., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P., …Scheltens, P. (2020). Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future. Alzheimer's and Dementia, 16(11), 1571-1581. https://doi.org/10.1002/alz.12143

We have provided an overview on the profound impact of COVID‐19 upon older people with Alzheimer's disease and other dementias and the challenges encountered in our management of dementia in different health‐care settings, including hospital, out‐pat... Read More about Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future.

Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial (2020)
Journal Article
Evans, S. R., Knutsson, M., Amarenco, P., Albers, G. W., Bath, P. M., Denison, H., …Johnston, S. C. (2020). Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial. Clinical Trials, 17(6), 617-626. https://doi.org/10.1177/1740774520941441

Background/Aims: Standard approaches to trial design and analyses can be inefficient and non-pragmatic. Failure to consider a range of outcomes impedes evidence-based interpretation and reduces power. Traditional approaches synthesizing information o... Read More about Methodologies for pragmatic and efficient assessment of benefits and harms: Application to the SOCRATES trial.

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis (2020)
Journal Article
Lim, S. T., Thijs, V., Murphy, S. J. X., Fernandez-Cadenas, I., Montaner, J., Offiah, C., …McCabe, D. J. H. (2020). Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis. Journal of Neurology, https://doi.org/10.1007/s00415-020-09932-y

Background The prevalence of ex vivo ‘high on-treatment platelet reactivity (HTPR)’ and its relationship with recurrent vascular events/outcomes in patients with ischaemic cerebrovascular disease (CVD) is unclear.

Methods A systematic review and... Read More about Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis.

The Landscape of Videofluoroscopy in the UK: A Web-Based Survey (2020)
Journal Article
Benfield, J. K., Michou, E., Everton, L. F., Mills, C., Hamdy, S., Bath, P. M., & England, T. J. (2020). The Landscape of Videofluoroscopy in the UK: A Web-Based Survey. Dysphagia, https://doi.org/10.1007/s00455-020-10130-1

Videofluoroscopy (VFS) is considered one of the gold-standard assessments of swallowing. Whilst guidelines for the application and conduct of VFS exist, their translation into clinical practice remain challenging. To build a greater understanding on... Read More about The Landscape of Videofluoroscopy in the UK: A Web-Based Survey.

Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients (2020)
Journal Article
Everton, L. F., Benfield, J. K., Hedstrom, A., Wilkinson, G., Michou, E., England, T. J., …Hamdy, S. (2020). Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients. Scientific Reports, 10, Article 7268. https://doi.org/10.1038/s41598-020-64208-9

Post stroke dysphagia (PSD) is common and associated with poor outcome. The Dysphagia Severity Rating Scale (DSRS), which grades how severe dysphagia is based on fluid and diet modification and supervision requirements for feeding, is used for clinic... Read More about Psychometric assessment and validation of the dysphagia severity rating scale in stroke patients.

Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan (2020)
Journal Article
Mair, G., Chappell, F., Martin, C., Dye, D., Bath, P. M., Muir, K. W., …Wardlaw, J. M. (2020). Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan. AMRC Open Research, 2, Article 20. https://doi.org/10.12688/amrcopenres.12904.1

Background: Artificial intelligence-based software may automatically detect ischaemic stroke lesions and provide an Alberta Stroke Program Early CT score (ASPECTS) on CT, and identify arterial occlusion and provide a collateral score on CTA. Large-sc... Read More about Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan.

Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease (2020)
Journal Article
Wardlaw, J., Bath, P. M., Doubal, F., Heye, A., Sprigg, N., Woodhouse, L. J., …The LACI-2 Trial Investigators. (2020). Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease. European Stroke Journal, 5(3), 297-308. https://doi.org/10.1177/2396987320920110

Background
Small vessel disease causes a quarter of ischaemic strokes (lacunar subtype), up to 45% of dementia either as vascular or mixed types, cognitive impairment and physical frailty. However, there is no specific treatment to prevent progressi... Read More about Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease.

UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings (2020)
Journal Article
McColl, B. W., Allan, S. M., McFall, A., Hietamies, T. M., Bernard, A., Aimable, M., …Quinn, T. J. (2020). UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings. Journal of Cerebral Blood Flow and Metabolism, 40(7), 1402-1414. https://doi.org/10.1177/0271678x20910552

© The Author(s) 2020. Assessment of outcome in preclinical studies of vascular cognitive impairment (VCI) is heterogenous. Through an ARUK Scottish Network supported questionnaire and workshop (mostly UK-based researchers), we aimed to determine unde... Read More about UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: questionnaire and workshop proceedings.

Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2) (2020)
Journal Article
Muir, K. W., Bulters, D., Willmot, M., Sprigg, N., Dixit, A., Ward, N., …Sinden, J. (2020). Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2). Journal of Neurology, Neurosurgery and Psychiatry, 91(4), 396-401. https://doi.org/10.1136/jnnp-2019-322515

Background

Human neural stem cell implantation may offer improved recovery from stroke. We investigated the feasibility of intracerebral implantation of the allogeneic human neural stem cell line CTX0E03 in the subacute—chronic recovery phase of... Read More about Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2).

Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group (2020)
Journal Article
Wilson, A., on behalf of the ESO Health Economics Working group, Cadilhac, D. A., Kim, J., Berge, E., Patel, A., …Ranta, A. (2020). Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group. European Stroke Journal, 5(2), 184-192. https://doi.org/10.1177/2396987319897466

Abstract Introduction: Approaches to economic evaluations of stroke therapies are varied and inconsistently described. An objective of the European Stroke Organisation (ESO) Health Economics Working Group is to standardise and improve the economic ev... Read More about Improving economic evaluations in stroke: A report from the ESO Health Economics Working Group.

Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage (2020)
Journal Article
Law, Z. K., Desborough, M., Rakkar, K., Bath, P. M., Bayraktutan, U., & Sprigg, N. (2020). Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage. Brain Hemorrhages, 1(1), 75-79. https://doi.org/10.1016/j.hest.2019.12.001

Endogenous fibrinolysis might lead to hematoma progression in spontaneous intracerebral hemorrhage (ICH). We studied plasma biomarkers of fibrinolysis and hemostasis in twenty-two patients with ICH and nine healthy controls (HC) in a single-center st... Read More about Elevated plasminogen activators are associated with hematoma progression in spontaneous intracerebral hemorrhage.

Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta‐analysis (2020)
Journal Article
Benfield, J. K., Everton, L. F., Bath, P. M., & England, T. J. (2020). Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta‐analysis. Journal of Clinical Nursing, 29(9-10), 1527-1538. https://doi.org/10.1111/jocn.15192

Introduction

Nurses and other nonspecialists in dysphagia are often trained to screen swallowing poststroke. There are many basic tools that test water only, they are usually conservative, and patients that fail the test remain nil by mouth until... Read More about Accuracy and clinical utility of comprehensive dysphagia screening assessments in acute stroke: A systematic review and meta‐analysis.

The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke: A Review (2019)
Journal Article
Bath, P. M., Appleton, J. P., & England, T. (2020). The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke: A Review. JAMA Neurology, 77(1), 114-124. https://doi.org/10.1001/jamaneurol.2019.4107

Importance: While there are a limited number of beneficial treatments for acute stroke (eg, stroke units, reperfusion, aspirin, hemicraniectomy), there are more negative (as opposed to neutral) interventions spanning multiple different mechanisms of... Read More about The Hazard of Negative (Not Neutral) Trials on Treatment of Acute Stroke: A Review.

Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage (2019)
Journal Article
Bath, P. M., Woodhouse, L. J., Krishnan, K., Appleton, J. P., Anderson, C. S., Berge, E., …Sprigg, N. (2019). Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage. Stroke, 50(11), 3064-3071. https://doi.org/10.1161/STROKEAHA.119.026389

Background and Purpose—
Pilot trials suggest that glyceryl trinitrate (GTN; nitroglycerin) may improve outcome when administered early after stroke onset.

Methods—
We undertook a multicentre, paramedic-delivered, ambulance-based, prospective ran... Read More about Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage.

Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization (2019)
Journal Article
Brainin, M., Feigin, V., Bath, P. M., Collantes, E., Martins, S., Pandian, J., …Teuschl, Y. (2019). Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization. International Journal of Stroke, 14(8), 818-825. https://doi.org/10.1177/1747493019873706

The increasing burden of stroke and dementia emphasizes the need for new, well-tolerated and cost-effective primary prevention strategies that can reduce the risks of stroke and dementia worldwide, and specifically in low- and middle-income countries... Read More about Multi-level community interventions for primary stroke prevention: A conceptual approach by the World Stroke Organization.

The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved] (2019)
Journal Article
Ker, K., Prieto-Merino, D., Sprigg, N., Mahmood, A., Bath, P., Kang Law, Z., …Roberts, I. (2019). The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved]. Wellcome Open Research, Article 120. https://doi.org/10.12688/wellcomeopenres.13262.3

Introduction: The Anti-fibrinolytics Trialists Collaboration aims to increase knowledge about the effectiveness and safety of anti-fibrinolytic treatment by conducting individual patient data (IPD) meta-analyses of randomised trials. This article pre... Read More about The effectiveness and safety of anti-fibrinolytics in patients with acute intracranial haemorrhage: statistical analysis plan for an individual patient data meta-analysis [version 3; peer review: 2 approved].

Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis (2019)
Journal Article
Greving, J. P., Diener, H., Reitsma, J., Bath, P., Csiba, L., Hacke, W., …Algra, A. (2019). Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis. Stroke, 50(7), 1812-1818. https://doi.org/10.1161/strokeaha.118.024497

© 2019 American Heart Association, Inc. Background and Purpose-We assessed the efficacy and safety of antiplatelet agents after noncardioembolic stroke or transient ischemic attack and examined how these vary according to patients' demographic and cl... Read More about Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis.

Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review (2019)
Journal Article
Krishnan, K., Bassilious, K., Eriksen, E., Bath, P. M., Sprigg, N., Brækken, S. K., …Sandset, E. C. (2019). Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review. European Stroke Journal, 4(3), 233-239. https://doi.org/10.1177/2396987319843701

Purpose
Acute vestibular syndrome – vertigo, nausea/vomiting, nystagmus and gait unsteadiness – is common, and differentiating posterior circulation stroke from a peripheral cause can be challenging. The National Institute of Health Stroke Scale (NI... Read More about Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review.

Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry (2019)
Journal Article
S Anderson, C., Robinson, T. G., Bray, B. D., Paley, L., Sprigg, N., Wang, X., …for the ENCHANTED Investigators and the SSNAP Collaboration. (2019). Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry. International Journal of Stroke, 14(7), 678-685. https://doi.org/10.1177/1747493019841246

© 2019 World Stroke Organization. Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results. Methods: Comparisons were made of baseline and out... Read More about Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous thrombolysis in England and Wales: Comparison with the Sentinel Stroke National Audit Programme registry.

14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: proceedings and summary of discussions (2019)
Journal Article
Sheth, S. A., Lopez-Rivera, V., Lee, S., Savitz, S. I., Liebeskind, D. S., Grotta, J. C., …Bath, P. (2019). 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: proceedings and summary of discussions. International Journal of Stroke, 14(4), 439-441. https://doi.org/10.1177/1747493019838760

The 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy (TTST) took place in Houston, Texas on 21–22 October 2018. Attended by 150þ invited global experts, the objectives of TTST 2018 were to explore the changing lands... Read More about 14th International Symposium on Thrombolysis, Thrombectomy and Acute Stroke Therapy: proceedings and summary of discussions.