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The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells (2018)
Journal Article
Crossland, H., Smith, K., Atherton, P. J., & Wilkinson, D. J. (2018). The metabolic and molecular mechanisms of hyperammonaemia and hyperethanolaemia induced protein catabolism in skeletal muscle cells. Journal of Cellular Physiology, 233(12), 9663-9673. doi:10.1002/jcp.26881

Hyperammonaemia and hyperethanolaemia are thought to be driving factors behind skeletal muscle myopathy in liver disease i.e. cirrhosis. Despite this, the singular and combined impacts of ethanol and ammonia induced protein catabolism are poorly defi... Read More

A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study (2017)
Journal Article
Crossland, H., Smith, K., Atherton, P. J., & Wilkinson, D. J. (2017). A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: a proof-of-concept study. Biochemical and Biophysical Research Communications, 494(3-4), doi:10.1016/j.bbrc.2017.10.085. ISSN 0006-291X

The precise roles that the major proteolytic pathways play in the regulation of skeletal muscle mass remain incompletely understood, in part due to technical limitations associated with current techniques used to quantify muscle protein breakdown (MP... Read More

Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism (2017)
Journal Article
Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J., Williams, J. P., …Atherton, P. J. (2017). Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition, doi:10.1016/j.clnu.2017.09.024. ISSN 0261-5614

Background & aims: β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in exercise. Of the two available forms of HMB (calcium (Ca-HMB) salt or f... Read More

Physiological adaptations to resistance exercise as a function of age (2017)
Journal Article
Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., & Atherton, P. J. (in press). Physiological adaptations to resistance exercise as a function of age. JCI insight, 2(17), doi:10.1172/jci.insight.95581. ISSN 2379-3708

BACKGROUND. The impact of resistance exercise training (RE-T) across the life span is poorly defined. METHODS. To resolve this, we recruited three distinct age cohorts of young (18–28 years; n = 11), middle-aged (45–55 years; n = 20), and older (n... Read More