All Outputs (5)

Update on the global prevalence and severity of kiwifruit allergy: a scoping review (2023)
Journal Article
James, C. A., Welham, S., & Rose, P. (2023). Update on the global prevalence and severity of kiwifruit allergy: a scoping review. International Journal of Food Science and Technology, 58(12), 6158-6181. https://doi.org/10.1111/ijfs.16680

The production and use of kiwifruit, and their derived products, has seen rapid growth in the food industry with some 4,467,099 tonnes produced in 2021. A key area of development has been the increased use of kiwifruit waste streams to support sustai... Read More about Update on the global prevalence and severity of kiwifruit allergy: a scoping review.

The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals (2023)
Journal Article
Alsaeedi, A., Welham, S., Rose, P., & Zhu, Y.-Z. (2023). The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals. Antioxidants, 12(4), Article 908. https://doi.org/10.3390/antiox12040908

Mammalian cells and tissues have the capacity to generate hydrogen sulfide gas (H2S) via catabolic routes involving cysteine metabolism. H2S acts on cell signaling cascades that are necessary in many biochemical and physiological roles important in t... Read More about The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals.

Signaling pathways in rheumatoid arthritis: implications for targeted therapy (2023)
Journal Article
Ding, Q., Hu, W., Wang, R., Yang, Q., Zhu, M., Li, M., …Zhu, Y. Z. (2023). Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduction and Targeted Therapy, 8, Article 68. https://doi.org/10.1038/s41392-023-01331-9

Rheumatoid arthritis (RA) is an incurable systemic autoimmune disease. Disease progression leads to joint deformity and associated loss of function, which significantly impacts the quality of life for sufferers and adds to losses in the labor force.... Read More about Signaling pathways in rheumatoid arthritis: implications for targeted therapy.

Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017) (2023)
Journal Article
Alsaeedi, A., Welham, S., & Rose, P. (2023). Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017). British Journal of Nutrition, 130(8), 1403-1415. https://doi.org/10.1017/S0007114523000417

Reduction in dietary vitamin B6 intakes is associated with increased relative risk of diseases such as cancer, atherosclerosis, and cognitive dysfunction. All forms of dietary vitamin B6 are converted to pyridoxal 5'-phosphate (PLP), that is needed f... Read More about Impact of lifestyle factors on dietary vitamin B6 intake and plasma pyridoxal 5'-phosphate level in UK adults: National Diet and Nutrition Survey Rolling Programme (NDNS) (2008-2017).

Recent updates in click and computational chemistry for drug discovery and development (2023)
Journal Article
Cai, J. H., Zhu, X. Z., Guo, P. Y., Rose, P., Liu, X. T., Liu, X., & Zhu, Y. Z. (2023). Recent updates in click and computational chemistry for drug discovery and development. Frontiers in Chemistry, 11, Article 1114970. https://doi.org/10.3389/fchem.2023.1114970

Drug discovery is a costly and time-consuming process with a very high failure rate. Recently, click chemistry and computer-aided drug design (CADD) represent popular areas for new drug development. Herein, we summarized the recent updates in click a... Read More about Recent updates in click and computational chemistry for drug discovery and development.