Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1
(2015)
Journal Article
Winkler, S., Jadhav, G. P., Kaur, I., Maryati, M., Airhihen, B., & Fischer, P. M. (2015). Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1. Bioorganic and Medicinal Chemistry Letters, 25(19), 4219-4224. https://doi.org/10.1016/j.bmcl.2015.07.095
Eukaryotic mRNA contains a 3? poly(A) tail, which plays important roles in the regulation of mRNA stability and translation. Well-characterized enzymes involved in the shortening of the poly(A) tail include the multi-subunit Ccr4-Not deadenylase, whi... Read More about Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1.