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The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study (2019)
Journal Article
Müller, C. P., Chu, C., Qin, L., Liu, C., Xu, B., Gao, H., …Schumann, G. (2019). The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study. Cerebral Cortex, doi:10.1093/cercor/bhy341

Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, mo... Read More

Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers (2019)
Journal Article
Wilkinson-Smith, V., Dellschaft, N., Ansell, J., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2019). Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers. Alimentary Pharmacology and Therapeutics, doi:10.1111/apt.15127

Background: Chronic constipation affects approximately 17% of the population worldwide and remains an important unmet need since patients are often dissatisfied with treatment. Kiwifruit may offer an alternative to traditional laxatives and have been... Read More

Peer victimization and its impact on adolescent brain development and psychopathology (2018)
Journal Article
Quinlan, E. B., Barker, E. D., Luo, Q., Banaschewski, T., Bokde, A. L. W., Bromberg, U., …IMAGEN Consortium, . (2018). Peer victimization and its impact on adolescent brain development and psychopathology. Molecular Psychiatry, doi:10.1038/s41380-018-0297-9

Chronic peer victimization has long-term impacts on mental health; however, the biological mediators of this adverse relationship are unknown. We sought to determine whether adolescent brain development is involved in mediating the effect of peer vic... Read More

Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis (2018)
Journal Article
Drury, R. J., Falah, Y., Gowland, P. A., Evangelou, N., Bright, M. G., & Francis, S. T. (2018). Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis. European Radiology, ISSN 0938-7994

Objectives Assess the feasibility of using an optimised ultra-high-field high-spatial-resolution low-distortion ASL MRI acquisition to measure focal haemodynamic pathology in cortical lesions (CLs) in Multiple Sclerosis (MS). Methods Twelve... Read More

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold (2018)
Journal Article
Hoad, C., Marciani, L., Spiller, R., Gowland, P., & Moran, G. (2018). Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: beyond the breath-hold. Neurogastroenterology and Motility, doi:10.1111/nmo.13466. ISSN 1350-1925

Background The symptoms of functional bowel disorders are common in postprandial but investigations are generally undertaken in the fasted state using invasive procedures. MRI provides a noninvasive tool to study the gastrointestinal tract in an u... Read More

Risk profiles for heavy drinking in adolescence: differential effects of gender (2018)
Journal Article
Seo, S., Beck, A., Matthis, C., Genauck, A., Banaschewski, T., Bokde, A. L., …Obermayer, K. (in press). Risk profiles for heavy drinking in adolescence: differential effects of gender. Addiction Biology, doi:10.1111/adb.12636. ISSN 1355-6215

Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk pr... Read More

Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI (2018)
Journal Article
Schwarz, S. T., Mougin, O., Xing, Y., Blazejewska, A., Bajaj, N., Auer, D. P., & Gowland, P. (in press). Parkinson's disease related signal change in the nigrosomes 1–5 and the substantia nigra using T2* weighted 7T MRI. NeuroImage: Clinical, 19, doi:10.1016/j.nicl.2018.05.027

Improved markers for the progression of Parkinson's disease (PD) are required. Previous work has proven that iron dependent MRI scans can detect the largest Nigrosome (N1) within the substantia nigra (SN) pars compacta and changes in PD. Histopatholo... Read More

Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study (2018)
Journal Article
Palaniyappan, L., Hodgson, O., Balain, V., Iwabuchi, S., Gowland, P., & Liddle, P. (in press). Structural covariance and cortical reorganization in schizophrenia: a MRI-based morphometric study. Psychological Medicine, doi:10.1017/S0033291718001010. ISSN 0033-2917

Background: In patients with schizophrenia, distributed abnormalities are observed in grey matter volume. A recent hypothesis posits that these distributed changes are indicative of a plastic reorganization process occurring in response to a function... Read More

Insights into the different effects of food on intestinal secretion using magnetic resonance imaging (2018)
Journal Article
Wilkinson-Smith, V. C., Major, G., Ashleigh, L., Murray, K., Hoad, C. L., Marciani, L., …Spiller, R. C. (2018). Insights into the different effects of food on intestinal secretion using magnetic resonance imaging. Journal of Parenteral and Enteral Nutrition, 42(8), 1342-1348. doi:10.1002/jpen.1157

Background: Plant foods may stimulate intestinal secretion through chemicals designed to deter herbivores, including lactucins in lettuce and rhein in rhubarb. This may increase ileostomy output and induce diarrhoea in people with intact bowels. Obj... Read More

Cortical differences in diverticular disease and correlation with symptom reports (2018)
Journal Article
Pitiot, A., Smith, J. K., Garratt, J., Francis, S. T., Gowland, P. A., Spiller, R. C., & Marciani, L. (2018). Cortical differences in diverticular disease and correlation with symptom reports. Neurogastroenterology and Motility, 30(7), doi:10.1111/nmo.13303. ISSN 1350-1925

Background Recent studies have shown that the brain of patients with gastrointestinal disease differ both structurally and functionally from that of controls. Highly somatizing diverticular disease (HSDD) patients were also shown to differ from... Read More

Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology (2017)
Journal Article
O'Halloran, L., Cao, Z., Ruddy, K., Jollans, L., Albaugh, M. D., Aleni, A., …Whelan, R. (2018). Neural circuitry underlying sustained attention in healthy adolescents and in ADHD symptomatology. NeuroImage, 169, doi:10.1016/j.neuroimage.2017.12.030. ISSN 1053-8119

Moment-to-moment reaction time variability on tasks of attention, often quantified by intra-individual response variability (IRV), provides a good indication of the degree to which an individual is vulnerable to lapses in sustained attention. Increa... Read More