All Outputs (12)

Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging (2019)
Journal Article
Chou, I., Tanasescu, R., Mougin, O. E., Gowland, P. A., Tench, C. R., Whitehouse, W. P., …Constantinescu, C. S. (2019). Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging. Scientific Reports, 9, Article 14378. https://doi.org/10.1038/s41598-019-50928-0

Whether the integrity of normal-appearing white matter (NAWM) is preserved in neuromyelitis optica spectrum disorders (NMOSD) is open to debate. To examine whether the tissue integrity of NAWM in NMOSD is compromised compared to that in healthy contr... Read More about Reduced Myelin Signal in Normal-appearing White Matter in Neuromyelitis Optica Measured by 7T Magnetic Resonance Imaging.

Identification of neurobehavioural symptom groups based on shared brain mechanisms (2019)
Journal Article
Ing, A., Sӓmann, P. G., Chu, C., Tay, N., Biondo, F., Jia, T., …IMAGEN Consortium. (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. Nature Human Behaviour, 3, 1306–1318. https://doi.org/10.1038/s41562-019-0738-8

Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural sympt... Read More about Identification of neurobehavioural symptom groups based on shared brain mechanisms.

Gastrointestinal peptides and small bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease (2019)
Journal Article
Khalaf, A., Hoad, C. L., Menys, A., Nowak, A., Radford, S., Taylor, S. A., …Moran, G. W. (2020). Gastrointestinal peptides and small bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease. American Journal of Clinical Nutrition, 111(1), 131–140. https://doi.org/10.1093/ajcn/nqz240

Background Crohn's disease (CD) patients suffer postprandial aversive symptoms, which can lead to anorexia and malnutrition. Changes in the regulation of gut hormones and gut dysmotility are believed to play a role. Objectives This study aimed t... Read More about Gastrointestinal peptides and small bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn’s disease.

T2*?weighted placental MRI: basic research tool or emerging clinical test for placental dysfunction? (2019)
Journal Article
Sørensen, A., Hutter, J., Seed, M., Grant, P. E., & Gowland, P. (2020). T2*‐weighted placental MRI: basic research tool or emerging clinical test for placental dysfunction?. Ultrasound in Obstetrics and Gynaecology, 55(3), 293-302. https://doi.org/10.1002/uog.20855

Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans (2019)
Journal Article
Alyami, J., Whitehouse, E., Yakubov, G. E., Pritchard, S. E., Hoad, C. L., Blackshaw, E., …Marciani, L. (2019). Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans. British Journal of Nutrition, https://doi.org/10.1017/S0007114519001880

Whole grain cereal breakfast consumption has been associated with beneficial effects on glucose and insulin metabolism as well as satiety. Pearl millet is a popular ancient grain variety that can be grown in hot, dry regions. However, little is known... Read More about Glycemic, Gastrointestinal, Hormonal and Appetitive Responses to Pearl Millet or Oats Porridge Breakfasts: a Randomized, Crossover Trial in Healthy Humans.

Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging (2019)
Journal Article
Lam, C., Sanders, D., Lanyon, P., Garsed, K., Foley, S., Pritchard, S., …Spiller, R. (2019). Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging. United European Gastroenterology Journal, 7(10), 1353-1360. https://doi.org/10.1177/2050640619860372

Background and aims: The regular overnight migrating motor complex (MMC) ensures that the normal fasting small bowel water content (SBWC) is minimised. We have applied our recently validated non-invasive magnetic resonance technique to assess SBWC... Read More about Increased fasting small-bowel water content in untreated coeliac disease and scleroderma as assessed by magnetic resonance imaging.

A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis (2019)
Journal Article
Murray, K., Hoad, C., Garratt, J., Kaviani, M., Marciani, L., Smith, J., …Spiller, R. (2019). A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis. PLoS ONE, 14(5), Article e0216528. https://doi.org/10.1371/journal.pone.0216528

Background Complications of diverticular disease are increasingly common, possibly linked to increasing obesity. Visceral fat could contribute to the development of symptomatic diverticular disease through its pro-inflammatory effects. Objective... Read More about A pilot study of visceral fat and its association with adipokines, stool calprotectin and symptoms in patients with diverticulosis.

Neuroimaging evidence for right orbitofrontal cortex differences in adolescents with emotional and behavioral dysregulation (2019)
Journal Article
Spechler, P. A., Chaarani, B., Orr, C., Mackey, S., Higgins, S. T., Banaschewski, T., …IMAGEN Consortium. (2019). Neuroimaging evidence for right orbitofrontal cortex differences in adolescents with emotional and behavioral dysregulation. Journal of the American Academy of Child and Adolescent Psychiatry, 58(11), 1092-1103. https://doi.org/10.1016/j.jaac.2019.01.021

Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype. Methods: Age 14 adolescents from the IMAGEN study were investigated. Latent class... Read More about Neuroimaging evidence for right orbitofrontal cortex differences in adolescents with emotional and behavioral dysregulation.

Low smoking-exposure, the adolescent brain, and the modulating role of CHRNA5 polymorphisms (2019)
Journal Article
Chaarani, B., Kan, K., Mackey, S., Spechler, P. A., Potter, A., Orr, C., …Garavan, H. (2019). Low smoking-exposure, the adolescent brain, and the modulating role of CHRNA5 polymorphisms. Biological Psychiatry, 4(7), 672-679. https://doi.org/10.1016/j.bpsc.2019.02.006

© 2019 Background: Studying the neural consequences of tobacco smoking during adolescence, including those associated with early light use, may help expose the mechanisms that underlie the transition from initial use to nicotine dependence in adultho... Read More about Low smoking-exposure, the adolescent brain, and the modulating role of CHRNA5 polymorphisms.

The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study (2019)
Journal Article
Müller, C. P., Chu, C., Qin, L., Liu, C., Xu, B., Gao, H., …Schumann, G. (2019). The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study. Cerebral Cortex, 29(4), 1736–1751. https://doi.org/10.1093/cercor/bhy341

Alcohol abuse is a major public health problem worldwide. Understanding the molecular mechanisms that control regular drinking may help to reduce hazards of alcohol consumption. While immunological mechanisms have been related to alcohol drinking, mo... Read More about The cortical neuroimmune regulator TANK affects emotional processing and enhances alcohol drinking: a translational study.

Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers (2019)
Journal Article
Wilkinson-Smith, V., Dellschaft, N., Ansell, J., Hoad, C., Marciani, L., Gowland, P., & Spiller, R. (2019). Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers. Alimentary Pharmacology and Therapeutics, 49(6), 759-768. https://doi.org/10.1111/apt.15127

Background: Chronic constipation affects approximately 17% of the population worldwide and remains an important unmet need since patients are often dissatisfied with treatment. Kiwifruit may offer an alternative to traditional laxatives and have been... Read More about Mechanisms underlying effects of kiwifruit on intestinal function shown by MRI in healthy volunteers.

Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments (2019)
Journal Article
Wesolowski, R., Blockley, N., Driver, I., Francis, S., & Gowland, P. (2019). Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments. NMR in Biomedicine, 32(3), 1-11. https://doi.org/10.1002/nbm.4061

A better understanding of the coupling between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is vital for furthering our understanding of the BOLD response. The aim of this study was to measure CBF-CBV coupling in different vas... Read More about Coupling between cerebral blood flow and cerebral blood volume: contributions of different vascular compartments.