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CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white fat adipocytes (2019)
Journal Article
Fedorenko, O. A., Pulbutr, P., Banke, E., Akaniro-Ejim, N. E., Bentley, D. C., Olofsson, C. S., …Smith, P. A. (2020). CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white fat adipocytes. Journal of Endocrinology, 244(2), 369–381. https://doi.org/10.1530/joe-19-0493

L-type channel antagonists are of therapeutic benefit in the treatment of hyperlipidaemia and insulin resistance. Our aim was to identify L-type voltage-gated Ca2+ channels in white fat adipocytes, and determine if they affect intracellular Ca2+, lip... Read More about CaV1.2 and CaV1.3 voltage-gated L-type Ca2+ channels in rat white fat adipocytes.

Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus (2019)
Journal Article
Hockley, A., Berger, J. I., Smith, P. A., Palmer, A. R., & Wallace, M. N. (2020). Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus. European Journal of Neuroscience, 51(4), 963-983. https://doi.org/10.1111/ejn.14572

The gaseous free radical, nitric oxide (NO) acts as a ubiquitous neuromodulator, contributing to synaptic plasticity in a complex way that can involve either long term potentiation or depression. It is produced by neuronal nitric oxide synthase (nNOS... Read More about Nitric oxide regulates the firing rate of neuronal subtypes in the guinea pig ventral cochlear nucleus.

Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function (2019)
Journal Article
Curry, L., Almukhtar, H., Alahmed, J., Roberts, R., & Smith, P. A. (2019). Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function. Toxicological Sciences, 169(2), 543–552. https://doi.org/10.1093/toxsci/kfz068

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognised “off-targets” for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolaemia, but which is also associated wit... Read More about Simvastatin inhibits L-type Ca 2+ -channel activity through impairment of mitochondrial function.

Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification (2019)
Journal Article
Brown, A. M., Evans, R. D., Smith, P. A., Rich, L. R., & Ransom, B. R. (2019). Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification. Physiological Reports, 7(5), 1-13. doi:10.14814/phy2.14007

Hypoglycemia is a common iatrogenic consequence of type 1 diabetes therapy that can lead to central nervous system injury and even death if untreated. In the absence of clinically effective neuroprotective drugs we sought to quantify the putative neu... Read More about Hypothermic neuroprotection during reperfusion following exposure to aglycemia in central white matter is mediated by acidification.

Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety (2019)
Journal Article
Cavanagh, R. J., Smith, P. A., & Stolnik, S. (2019). Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety. Molecular Pharmaceutics, 16(2), 618-631. https://doi.org/10.1021/acs.molpharmaceut.8b00934

Amphipathic, nonionic, surfactants are widely used in pharmaceutical, food, and agricultural industry to enhance product features; as pharmaceutical excipients, they are also aimed at increasing cell membrane permeability and consequently improving o... Read More about Exposure to a Nonionic Surfactant Induces a Response Akin to Heat-Shock Apoptosis in Intestinal Epithelial Cells: Implications for Excipients Safety.

Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case (2018)
Journal Article
Real, J., Miranda, C., Olofsson, C. S., & Smith, P. A. (2018). Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case. Endocrinology, Diabetes and Metabolism Journal, 1(2), https://doi.org/10.1002/edm2.17

Aims KATP ion channels play a key role in glucose‐stimulated insulin secretion. However, many drugs block KATP as “off targets” leading to hyperinsulinaemia and hypoglycaemia. As such drugs are often lipophilic, the aim was to examine the relation... Read More about Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case.

Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition (2017)
Journal Article
Helaly, A. N., Elmorsy, E., Al-Ghafari, A., Helaly, A., Hisab, A. S., Oehrle, B., & Smith, P. A. (2017). Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition. Toxicological Sciences, 158(2), 286-301. https://doi.org/10.1093/toxsci/kfx090

Diabetes mellitus risk is increased by prolonged usage of antidepressants (ADs). Although various mechanisms are suggested for their diabetogenic potential, whether a direct effect of ADs on pancreatic β-cells is involved is unclear. We examined this... Read More about Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition.

Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics (2015)
Journal Article
Elmorsy, E., & Smith, P. A. (2015). Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics. Biochemical and Biophysical Research Communications, 460(3), 857-862. https://doi.org/10.1016/j.bbrc.2015.03.122

Antipsychotics (APs) are widely used medications, however these are not without side effects such as disruption of blood brain barrier function (BBB). To investigate this further we have studied the chronic effects of the typical APs, chlorpromazine... Read More about Bioenergetic disruption of human micro-vascular endothelial cells by antipsychotics.

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier (2014)
Journal Article
Elmorsy, E., Elzalabany, L. M., Elsheikha, H. M., & Smith, P. A. (2014). Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier. Brain Research, 1583(1), 255-268. https://doi.org/10.1016/j.brainres.2014.08.011

© 2014 Elsevier B.V. All rights reserved. Although the mechanisms of action of antipsychotics (APs) on neuronal function are well understood, very little is known about their effects on cells of the blood-brain barrier (BBB); one function of which is... Read More about Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.

Etiology of the membrane potential of rat white fat adipocytes (2014)
Journal Article
Bentley, D. C., Pulbutr, P., Chan, S., & Smith, P. A. (2014). Etiology of the membrane potential of rat white fat adipocytes. AJP - Endocrinology and Metabolism, 307(2), E161-E175. https://doi.org/10.1152/ajpendo.00446.2013

The plasma membrane potential (Vm) is key to many physiological processes, however its ionic aetiology in white fat adipocytes is poorly characterised. To address this question, we have employed the perforated patch current-clamp and cell-attached pa... Read More about Etiology of the membrane potential of rat white fat adipocytes.

Hydrogen sulphide mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats (2013)
Journal Article
White, B. J., Smith, P. A., & Dunn, W. R. (2013). Hydrogen sulphide mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats. British Journal of Pharmacology, 168(4), 785-793. https://doi.org/10.1111/j.1476-5381.2012.02187.x

Background and Purpose Hydrogen sulphide (H2S) is a gas that has recently been shown to have biological activity. In the majority of blood vessels studied so far, H2S has been shown to cause vasorelaxation, although contractile responses have been re... Read More about Hydrogen sulphide mediated vasodilatation involves the release of neurotransmitters from sensory nerves in pressurized mesenteric small arteries isolated from rats.

Surface electromyography reveals males have a slower patellar reflex than females (2012)
Journal Article
Vickery, H. S., & Smith, P. A. (2012). Surface electromyography reveals males have a slower patellar reflex than females. Journal of Electro - myography and Kinesiology, 22(6), 990-996. https://doi.org/10.1016/j.jelekin.2012.06.001

In humans the cross sectional area of spinal motor neurons at L3 is larger in males than in females. Since these contribute to the control of the quadriceps femoris muscle group and are involved in the patellar reflex (PR), gender differences in the... Read More about Surface electromyography reveals males have a slower patellar reflex than females.

Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse (2009)
Journal Article
Ward, D. R., Dear, F. M., Ward, I. A., Anderson, S. I., Spergel, D. J., Smith, P. A., & Ebling, F. J. (2009). Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse. PLoS ONE, 4(4), https://doi.org/10.1371/journal.pone.0005322

Background: Secretion of gonadotropin-releasing hormone (GnRH) produced in neurons in the basal forebrain is the primary regulator of reproductive maturation and function in mammals. Peptidergic signals relating to circadian timing and energy balance... Read More about Innervation of gonadotropin-releasing hormone neurons by peptidergic neurons conveying circadian or energy balance information in the mouse.


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