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Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake (2018)
Journal Article
Constantin-Teodosiu, D., Cederblad, G., Bergstrom, M., & Greenhaff, P. L. (2019). Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake. Clinical Nutrition, 38(2), 948-953. https://doi.org/10.1016/j.clnu.2018.02.001

Background & aims: Exercise activates muscle pyruvate dehydrogenase complex (PDC), but moderate intensity exercise fails to fully activate muscle PDC after high-fat diet [1]. We investigated whether maximal intensity exercise overcomes this inhibitio... Read More about Maximal-intensity exercise does not fully restore muscle pyruvate dehydrogenase complex activation after 3 days of high-fat dietary intake.

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women (2017)
Journal Article
Wilkinson, D. J., Bukhari, S. S., Phillips, B. E., Limb, M. C., Cegielski, J., Brook, M. S., …Atherton, P. J. (2018). Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women. Clinical Nutrition, 37(6), 2011-2021. https://doi.org/10.1016/j.clnu.2017.09.008

© 2017 The Authors Background & aims: Impaired anabolic responses to nutrition and exercise contribute to loss of skeletal muscle mass with ageing (sarcopenia). Here, we tested responses of muscle protein synthesis (MPS), in the under represented gr... Read More about Effects of leucine-enriched essential amino acid and whey protein bolus dosing upon skeletal muscle protein synthesis at rest and after exercise in older women.

Muscle thickness correlates to muscle cross sectional area in the assessment of strength training induced hypertrophy (2017)
Journal Article
Franchi, M. V., Longo, S., Mallinson, J. E., Quinlan, J. I., Taylor, T., Greenhaff, P. L., & Narici, M. V. (in press). Muscle thickness correlates to muscle cross sectional area in the assessment of strength training induced hypertrophy. Scandinavian Journal of Medicine and Science in Sports, 28(3), https://doi.org/10.1111/sms.12961

Aim: Muscle thickness (MT) measured by ultrasound has been used to estimate cross-sectional area (measured by CT and MRI) at a single time-point. We tested whether MT could be used as a valid marker of MRI determined muscle anatomical cross-sectional... Read More about Muscle thickness correlates to muscle cross sectional area in the assessment of strength training induced hypertrophy.

Physiological adaptations to resistance exercise as a function of age (2017)
Journal Article
Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2017). Physiological adaptations to resistance exercise as a function of age. JCI insight, 2(17), Article e95581. https://doi.org/10.1172/jci.insight.95581

BACKGROUND. The impact of resistance exercise training (RE-T) across the life span is poorly defined. METHODS. To resolve this, we recruited three distinct age cohorts of young (18–28 years; n = 11), middle-aged (45–55 years; n = 20), and... Read More about Physiological adaptations to resistance exercise as a function of age.

Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent (2017)
Journal Article
Porter, C., Constantin-Teodosiu, D., Constantin, D., Leighton, B., Poucher, S. M., & Greenhaff, P. L. (2017). Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent. Journal of Physiology, 595(17), 5765-5780. https://doi.org/10.1113/jp274415

The body carnitine pool is primarily confined to skeletal muscle, where it regulates carbohydrate (CHO) and fat usage. Mildronate (3-(2,2,2-trimethylhydrazinium)-propionate) inhibits carnitine synthesis and tissue uptake, but the impact of carnitine... Read More about Muscle carnitine availability plays a central role in regulating fuel metabolism in the rodent.

Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats (2017)
Journal Article
Crossland, H., Constantin-Teodosiu, D., Gardiner, S. M., & Greenhaff, P. (2017). Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats. Clinical Science, 131(13), 1437-1447. https://doi.org/10.1042/CS20170958

The peroxisome proliferator-activated receptor γ (PPARγ) agonist rosiglitazone (Rosi) appears to provide protection against organ dysfunction during endotoxaemia. We examined the potential benefits of Rosi on skeletal muscle protein maintenance and c... Read More about Peroxisome proliferator-activated receptor γ agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats.

Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review (2016)
Journal Article
Rudrappa, S. S., Wilkinson, D., Greenhaff, P. L., Smith, K., Idris, I., & Atherton, P. J. (2016). Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review. Frontiers in Physiology, 7(361), https://doi.org/10.3389/fphys.2016.00361

The ever increasing burden of an ageing population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle... Read More about Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein Synthesis, Breakdown, and Insulin Resistance—A Qualitative Review.

Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercomposition during the initial 24 hrs of recovery following prolonged exhaustive exercise in humans (2016)
Journal Article
Roberts, P. A., Fox, J., Peirce, N., Jones, S. W., Casey, A., & Greenhaff, P. L. (2016). Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercomposition during the initial 24 hrs of recovery following prolonged exhaustive exercise in humans. Amino Acids, 48(8), 1831–1842. https://doi.org/10.1007/s00726-016-2252-x

Muscle glycogen availability can limit endurance exercise performance. We previously demonstrated 5 days of creatine (Cr) and carbohydrate (CHO) ingestion augmented post-exercise muscle glycogen storage compared to CHO feeding alone in healthy volunt... Read More about Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercomposition during the initial 24 hrs of recovery following prolonged exhaustive exercise in humans.

The effect of age and unilateral leg immobilisation for 2 weeks on substrate ulilisation during moderate-intensity exercise in human skeletal muscle (2016)
Journal Article
Vigelsø, A., Gram, M., Dybboe, R., Kuhlman, A., Prats, C., Greenhaff, P. L., …Helge, J. (2016). The effect of age and unilateral leg immobilisation for 2 weeks on substrate ulilisation during moderate-intensity exercise in human skeletal muscle. Journal of Physiology, 594(8), 2339-2358. https://doi.org/10.1113/jp271712

Age and inactivity have been associated with intramuscular triglyceride (IMTG) accumulation. Here, we attempt to disentangle these factors by studying the effect of 2 weeks of unilateral leg immobilization on substrate utilization across the legs dur... Read More about The effect of age and unilateral leg immobilisation for 2 weeks on substrate ulilisation during moderate-intensity exercise in human skeletal muscle.

Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men (2015)
Journal Article
Shannon, C. E., Nixon, A. V., Greenhaff, P. L., & Stephens, F. B. (2016). Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men. American Journal of Clinical Nutrition, 103(1), https://doi.org/10.3945/ajcn.115.119826

BACKGROUND: Increasing skeletal muscle carnitine content represents an appealing intervention in conditions of perturbed lipid metabolism such as obesity and type 2 diabetes but requires chronic L-carnitine feeding on a daily basis in a high-carbo... Read More about Protein ingestion acutely inhibits insulin-stimulated muscle carnitine uptake in healthy young men.

The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans (2014)
Journal Article

The integrin-adhesome network, which contains >150 proteins, is mechano-transducing and located at discreet positions along the cell-cell and cell-extracellular matrix interface. A small subset of the integrin-adhesome is known to maintain normal mus... Read More about The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans.