Research Repository

See what's under the surface


Reviving phage therapy for the treatment of cholera (2018)
Journal Article
Bhandare, S., Colom, J., Baig, A., Ritchie, J. M., Bokhari, H., Shah, M. A., …Atterbury, R. J. (2018). Reviving phage therapy for the treatment of cholera. Journal of Infectious Diseases, doi:10.1093/infdis/jiy563

Cholera remains a major risk in developing countries, particularly after natural or man-made disasters. Vibrio cholerae El Tor is the most important cause of these outbreaks, and is becoming increasingly resistant to antibiotics, so alternative thera... Read More

Complete genome sequences of seven Vibrio cholerae phages isolated in China (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Su, J., Barrow, P. A., & Atterbury, R. J. (2017). Complete genome sequences of seven Vibrio cholerae phages isolated in China. Genome Announcements, 5(47), doi:10.1128/genomeA.01019-17. ISSN 2169-8287

The complete genome sequences of seven closely related Vibrio cholerae phages isolated from environmental sites in southeastern China are reported here. Phages QH, CJY, H1, H2, H3, J2, and J3 are members of the Podoviridae family and are highly simil... Read More

Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29 (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Hooton, S. P., Barrow, P. A., & Atterbury, R. J. (2017). Complete genome sequences of Vibrio cholera: specific bacteriophages 24 and X29. Genome Announcements, 5(46), doi:10.1128/genomeA.01013-17. ISSN 2169-8287

The complete genomes of two Vibrio cholerae bacteriophages of potential interest for cholera bacteriophage (phage) therapy were sequenced and annotated. The genome size of phage 24 is 44,395 bp encoding 71 putative proteins, and that of phage X29 is... Read More

Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection (2017)
Journal Article
Baig, A., Colom, J., Barrow, P., Schouler, C., Moodley, A., Lavigne, R., & Atterbury, R. J. (2017). Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection. Frontiers in Microbiology, 8, doi:10.3389/fmicb.2017.01652. ISSN 1664-302X

We have performed microbiological and genomic characterization of an historic collection of nine bacteriophages, specifically infecting a K1 E. coli O18:K1:H7 ColV+ strain. These phages were isolated from sewage and tested for their efficacy in vivo... Read More

Molecular approaches to the diagnosis and monitoring of production diseases in pigs (2017)
Journal Article
Giles, T. A., Belkhiri, A., Barrow, P. A., & Foster, N. (2017). Molecular approaches to the diagnosis and monitoring of production diseases in pigs. Research in Veterinary Science, 114, doi:10.1016/j.rvsc.2017.05.016. ISSN 0034-5288

Production disease in pigs is caused by a variety of different pathogens, mainly enteric and respiratory and can result in significant economic loss. Other factors such as stress, poor husbandry and nutrition can also contribute to an animal's suscep... Read More

Detection of a Yersinia pestisgene homologue in rodent samples (2016)
Journal Article
Giles, T. A., Greenwood, A. D., Tsangaras, K., Giles, T. C., Barrow, P. A., Hannant, D., …Yon, L. (2016). Detection of a Yersinia pestisgene homologue in rodent samples. PeerJ, 4, doi:10.7717/peerj.2216. ISSN 2167-8359

A homologue to a widely used genetic marker, pla, for Yersinia pestis has been identified in tissue samples of two species of rat (Rattus rattus and Rattus norvegicus) and of mice (Mus musculus and Apodemus sylvaticus) using a microarray based platfo... Read More

CD95-mediated calcium signaling promotes T helper 17 trafficking to inflamed organs in lupus-prone mice (2016)
Journal Article
Poissonnier, A., Sanséau, D., Le Gallo, M., Malleter, M., Levoin, N., Viel, R., …Legembre, P. (2016). CD95-mediated calcium signaling promotes T helper 17 trafficking to inflamed organs in lupus-prone mice. Immunity, 45(1), doi:10.1016/j.immuni.2016.06.028. ISSN 1074-7613

CD95 ligand (CD95L) is expressed by immune cells and triggers apoptotic death. Metalloprotease-cleaved CD95L (cl-CD95L) is released into the bloodstream but does not trigger apoptotic signaling. Hence, the pathophysiological role of cl-CD95L remains... Read More

Using combined diagnostic test results to hindcast trends of infection from cross-sectional data (2016)
Journal Article
Rydevik, G., Innocent, G. T., Marion, G., Davidson, R. S., White, P. C., Billinis, C., …Hutchings, M. R. (2016). Using combined diagnostic test results to hindcast trends of infection from cross-sectional data. PLoS Computational Biology, 12(7), doi:10.1371/journal.pcbi.1004901. ISSN 1553-734X

Infectious disease surveillance is key to limiting the consequences from infectious pathogens and maintaining animal and public health. Following the detection of a disease outbreak, a response in proportion to the severity of the outbreak is require... Read More

Development of a DNA-based microarray for the detection of zoonotic pathogens in rodent species (2015)
Journal Article
Giles, T., Yon, L., Hannant, D., Barrow, P., & Abu-Median, A. (2015). Development of a DNA-based microarray for the detection of zoonotic pathogens in rodent species. Molecular and Cellular Probes, 29(6), doi:10.1016/j.mcp.2015.07.005. ISSN 0890-8508

The demand for diagnostic tools that allow simultaneous screening of samples for multiple pathogens is increasing because they overcome the limitations of other methods, which can only screen for a single or a few pathogens at a time. Microarrays off... Read More

IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c (2015)
Journal Article
Higgins, J., Mutamba, S., Mahida, Y. R., Barrow, P., & Foster, N. (2015). IL-36α induces maturation of Th1-inducing human MDDC and synergises with IFN-γ to induce high surface expression of CD14 and CD11c. Human Immunology, 76(4), doi:10.1016/j.humimm.2015.01.012. ISSN 0198-8859

We show that IL-36α induced maturation of human MDDCs and stimulated differentiation of IFN-γ producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36β in doing so. For the first time, we also show that IL-36α induced expression of CD14... Read More

Fleas and smaller fleas: virotherapy for parasite infections (2013)
Journal Article
Hyman, P., Atterbury, R. J., & Barrow, P. (2013). Fleas and smaller fleas: virotherapy for parasite infections. Trends in Microbiology, 21(5), doi:10.1016/j.tim.2013.02.006. ISSN 0966-842X

Bacteriophages are viruses of bacteria that are used for controlling bacterial food-borne pathogens and have been proposed for more extensive usage in infection control. Protists are now recognised to harbour viruses and virus-like particles. We prop... Read More