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Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid (2020)
Journal Article
Spankie, T. J., Haywood, A. L., Dottorini, T., Barrow, P. A., & Hirst, J. D. (2020). Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid. Journal of Molecular Graphics and Modelling, 101, Article 107723. https://doi.org/10.1016/j.jmgm.2020.107723

© 2020 Elsevier Inc. One promising strategy to combat antimicrobial resistance is to use bacteriophages that attach to the sex pili produced by transmissible antimicrobial resistance (AMR) plasmids, infect AMR bacteria and select for loss of the AMR... Read More about Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid.

Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage (2020)
Journal Article
Atterbury, R. J., Gigante, A. M., Rubio Lozano, M. D. L. S., Méndez Medina, R. D., Robinson, G., Alloush, H., …Allen, V. M. (2020). Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage. Virology Journal, 17, Article 98. https://doi.org/10.1186/s12985-020-01368-0

Background: Enteric infections caused by Salmonella spp. remain a major public health burden worldwide. Chickens are known to be a major reservoir for this zoonotic pathogen. The presence of Salmonella in poultry farms and abattoirs is associated wit... Read More about Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage.

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface (2020)
Journal Article
Domínguez-Medina, C. C., Pérez-Toledo, M., Schager, A. E., Marshall, J. L., Cook, C. N., Bobat, S., …Cunningham, A. F. (2020). Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface. Nature Communications, 11, Article 851. https://doi.org/10.1038/s41467-020-14655-9

Lipopolysaccharide (LPS) O-antigen (O-Ag) is known to limit antibody binding to surface antigens, although the relationship between antibody, O-Ag and other outer-membrane antigens is poorly understood. Here we report, immunization with the trimeric... Read More about Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.

Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity (2019)
Journal Article
Colom, J., Batista, D., Baig, A., Tang, Y., Liu, S., Yuan, F., …Barrow, P. (2019). Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity. Scientific Reports, 9, 1-11. https://doi.org/10.1038/s41598-019-48483-9

Antimicrobial resistance (AMR) is now a major global problem largely resulting from the overuse of antibiotics in humans and livestock. In some AMR bacteria, resistance is encoded by conjugative plasmids expressing sex-pili that can readily spread re... Read More about Sex pilus specific bateriophage to drive bacterial population towards antibiotic sensitivity.

Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice (2019)
Journal Article
Askar, B., Higgins, J., Barrow, P., & Foster, N. (2020). Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice. Cytokine, 125, Article 154787. https://doi.org/10.1016/j.cyto.2019.154787

© 2019 Elsevier Ltd Studies have shown that administration of vasoactive intestinal peptide (VIP) in mice rescues them from lethal endotoxaemia and that this is correlated with decreased concentration of inflammatory cytokines. VIP has, therefore, be... Read More about Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice.

Reviving Phage Therapy for the Treatment of Cholera (2018)
Journal Article
Bhandare, S., Colom, J., Baig, A., Ritchie, J. M., Bokhari, H., Shah, M. A., …Atterbury, R. J. (2019). Reviving Phage Therapy for the Treatment of Cholera. Journal of Infectious Diseases, 219(5), 786-794. https://doi.org/10.1093/infdis/jiy563

Cholera remains a major risk in developing countries, particularly after natural or man-made disasters. Vibrio cholerae El Tor is the most important cause of these outbreaks, and is becoming increasingly resistant to antibiotics, so alternative thera... Read More about Reviving Phage Therapy for the Treatment of Cholera.

A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response (2018)
Journal Article
Tang, Y., Foster, N., Jones, M. A., & Barrow, P. A. (2018). A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response. Infection and Immunity, 86(8), Article e00307-18. https://doi.org/10.1128/IAI.00307-18

Salmonella enterica infection affects a wide range of animals and human and a small number of serovars cause typhoid-like infections, one characteristic of which is persistent infection in convalescents. The avian specific serovar S Pullorum produces... Read More about A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response.

Complete Genome Sequences of Seven Vibrio cholerae Phages Isolated in China (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Su, J., Barrow, P. A., & Atterbury, R. J. (2017). Complete Genome Sequences of Seven Vibrio cholerae Phages Isolated in China. Genome Announcements, 5(47), Article e01019-17. https://doi.org/10.1128/genomeA.01019-17

The complete genome sequences of seven closely related Vibrio cholerae phages isolated from environmental sites in southeastern China are reported here. Phages QH, CJY, H1, H2, H3, J2, and J3 are members of the Podoviridae family and are highly simil... Read More about Complete Genome Sequences of Seven Vibrio cholerae Phages Isolated in China.

Complete Genome Sequences of Vibrio cholerae -Specific Bacteriophages 24 and X29 (2017)
Journal Article
Bhandare, S. G., Warry, A., Emes, R. D., Hooton, S. P., Barrow, P. A., & Atterbury, R. J. (2017). Complete Genome Sequences of Vibrio cholerae -Specific Bacteriophages 24 and X29. Genome Announcements, 5(46), Article e01013. https://doi.org/10.1128/genomeA.01013-17

The complete genomes of two Vibrio cholerae bacteriophages of potential interest for cholera bacteriophage (phage) therapy were sequenced and annotated. The genome size of phage 24 is 44,395 bp encoding 71 putative proteins, and that of phage X29 is... Read More about Complete Genome Sequences of Vibrio cholerae -Specific Bacteriophages 24 and X29.

Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection (2017)
Journal Article
Baig, A., Colom, J., Barrow, P., Schouler, C., Moodley, A., Lavigne, R., & Atterbury, R. J. (2017). Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection. Frontiers in Microbiology, 8, Article 1652. https://doi.org/10.3389/fmicb.2017.01652

We have performed microbiological and genomic characterization of an historic collection of nine bacteriophages, specifically infecting a K1 E. coli O18:K1:H7 ColV+ strain. These phages were isolated from sewage and tested for their efficacy in vivo... Read More about Biology and genomics of an historic therapeutic Escherichia coli bacteriophage collection.

Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken (2017)
Journal Article
Barbosa, F. D. O., Freitas Neto, O. C. D., Batista, D. F. A., Almeida, A. M. D., Rubio, M. D. S., Alves, L. B. R., …Berchieri Junior, A. (in press). Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken. Brazilian Journal of Microbiology, https://doi.org/10.1016/j.bjm.2017.01.012

Salmonella Enteritidis causes fowl paratyphoid in poultry and is frequently associated to outbreaks of food-borne diseases in humans. The role of flagella and flagella-mediated motility into host-pathogen interplay is not fully understood and require... Read More about Contribution of flagella and motility to gut colonisation and pathogenicity of Salmonella Enteritidis in the chicken.

Identification by PCR signature-tagged mutagenesis of attenuated Salmonella Pullorum mutants and corresponding genes in a chicken embryo model (2017)
Journal Article
Geng, S., Tian, Q., Guo, R., Jiao, Y., Barrow, P., Yin, C., …Jiao, X. (2017). Identification by PCR signature-tagged mutagenesis of attenuated Salmonella Pullorum mutants and corresponding genes in a chicken embryo model. Microbial Pathogenesis, 104, https://doi.org/10.1016/j.micpath.2017.01.014

A key feature of the fowl-specific pathogen Salmonella Pullorum is its vertical transmission to progeny via the egg. In this study, PCR signature-tagged mutagenesis identified nine genes of a strain of S. Pullorum that contributed to survival in the... Read More about Identification by PCR signature-tagged mutagenesis of attenuated Salmonella Pullorum mutants and corresponding genes in a chicken embryo model.

Detection of transmissible viral proventriculitis (TVP) and Chicken proventricular necrosis virus (CPNV) in the United Kingdom (2016)
Journal Article
Grau-Roma, L., Reid, K., de Brot, S., Jennison, R., Barrow, P., Sánchez, R., …Majó, N. (2017). Detection of transmissible viral proventriculitis (TVP) and Chicken proventricular necrosis virus (CPNV) in the United Kingdom. Avian Pathology, 46(1), 68-75. https://doi.org/10.1080/03079457.2016.1207751

Increasing evidence suggests that a new birnavirus, named Chicken proventricular necrosis virus (CPNV), is the aetiological agent of transmissible viral proventriculitis (TVP). The present work aimed to explore the possible presence of both TVP and C... Read More about Detection of transmissible viral proventriculitis (TVP) and Chicken proventricular necrosis virus (CPNV) in the United Kingdom.

CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice (2016)
Journal Article
Poissonnier, A., Sanséau, D., Le Gallo, M., Malleter, M., Levoin, N., Viel, R., …Legembre, P. (2016). CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. Immunity, 45(1), 209-223. https://doi.org/10.1016/j.immuni.2016.06.028

CD95 ligand (CD95L) is expressed by immune cells and triggers apoptotic death. Metalloprotease-cleaved CD95L (cl-CD95L) is released into the bloodstream but does not trigger apoptotic signaling. Hence, the pathophysiological role of cl-CD95L remains... Read More about CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice.

Using combined diagnostic test results to hindcast trends of infection from cross-sectional data (2016)
Journal Article
Rydevik, G., Innocent, G. T., Marion, G., Davidson, R. S., White, P. C., Billinis, C., …Hutchings, M. R. (2016). Using combined diagnostic test results to hindcast trends of infection from cross-sectional data. PLoS Computational Biology, 12(7), 1-19. https://doi.org/10.1371/journal.pcbi.1004901

Infectious disease surveillance is key to limiting the consequences from infectious pathogens and maintaining animal and public health. Following the detection of a disease outbreak, a response in proportion to the severity of the outbreak is require... Read More about Using combined diagnostic test results to hindcast trends of infection from cross-sectional data.

IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation (2016)
Journal Article
Penha, R., Higgins, J., Mutamba, S., Barrow, P., Mahida, Y. R., & Foster, N. (2016). IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation. Cytokine, 85, https://doi.org/10.1016/j.cyto.2016.05.023

We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during s... Read More about IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation.

Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum (2016)
Journal Article
Lopes, P., Freitas Neto, O., Batista, D., Denadai, J., Alarcon, M., Almeida, A., …Berchieri, A. (2016). Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum. Veterinary Journal, 214, https://doi.org/10.1016/j.tvjl.2016.05.006

Salmonella enterica subsp. enterica serovar Gallinarum biovar Gallinarum (SG) causes fowl typhoid (FT), a septicaemic disease which can result in high mortality in poultry flocks. The absence of flagella in SG is thought to favour systemic invasion,... Read More about Experimental infection of chickens by a flagellated motile strain of Salmonella enterica serovar Gallinarum biovar Gallinarum.

Combination of competitive exclusion and immunisation with a live Salmonella vaccine in newly hatched chickens: immunological and microbiological effects (2016)
Journal Article
Braukmann, M., Barrow, P., Berndt, A., & Methner, U. (2016). Combination of competitive exclusion and immunisation with a live Salmonella vaccine in newly hatched chickens: immunological and microbiological effects. Research in Veterinary Science, 107, https://doi.org/10.1016/j.rvsc.2016.05.001

In addition to evaluating the efficacy potential of a combined use of vaccination and competitive exclusion (CE) against Salmonella exposure in chicks at 3-days of age, a live Salmonella Enteritidis vaccine (SE-LV) and a CE culture were tested for th... Read More about Combination of competitive exclusion and immunisation with a live Salmonella vaccine in newly hatched chickens: immunological and microbiological effects.

Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs (2015)
Journal Article
Foster, N., Richards, L., Higgins, J., Kanellos, T., & Barrow, P. (2016). Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs. Research in Veterinary Science, 104, https://doi.org/10.1016/j.rvsc.2015.12.013

We show that oral inoculation of 14 day old conventional piglets with a rough attenuated Salmonella enterica serovar Infantis 1326/28?r (serogroup C1), 24 h prior to oral challenge with S. enterica serovar Typhimurium 4/74 (serogroup B), resulted in... Read More about Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs.