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Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition (2017)
Journal Article
Elmorsy, E., Al-Ghafari, A., Helaly, A., Hisab, A. S., Oehrle, B., & Smith, P. A. (2017). Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition. Toxicological Sciences, 158(2), 286-301. https://doi.org/10.1093/toxsci/kfx090

Diabetes mellitus risk is increased by prolonged usage of antidepressants (ADs). Although various mechanisms are suggested for their diabetogenic potential, whether a direct effect of ADs on pancreatic β-cells is involved is unclear. We examined this... Read More about Therapeutic concentrations of antidepressants inhibit pancreatic beta-cell function via mitochondrial complex inhibition.