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RpoS differentially affects the general stress response and biofilm formation in the endophytic Serratia plymuthica G3 (2015)
Journal Article
Liu, X., Wu, Y., Chen, Y., Xu, F., Halliday, N., Gao, K., …Camara Garcia, M. (2016). RpoS differentially affects the general stress response and biofilm formation in the endophytic Serratia plymuthica G3. Research in Microbiology, 167(3), 168-177. doi:10.1016/j.resmic.2015.11.003

The σS subunit RpoS of RNA polymerase functions as a master regulator of the general stress response in Escherichia coli and related bacteria. RpoS has been reported to modulate biocontrol properties in the rhizobacterium Serratia plymuthica IC1270.... Read More

Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis (2015)
Journal Article
Barr, H. L., Halliday, N., Cámara, M., Barrett, D. A., Williams, P., Forrester, D. L., …Fogarty, A. W. (2015). Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis. European Respiratory Journal, 46(4), doi:10.1183/09031936.00225214. ISSN 0903-1936

ABSTRACT Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection. A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary e... Read More

Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule (2015)
Journal Article
Soh, E. Y., Chhabra, S. R., Halliday, N., Heeb, S., Müller, C., Birmes, F. S., …Williams, P. (2015). Biotic inactivation of the Pseudomonas aeruginosa quinolone signal molecule. Environmental Microbiology, 17(11), doi:10.1111/1462-2920.12857. ISSN 1462-2912

In Pseudomonas aeruginosa, quorum sensing (QS) regulates the production of secondary metabolites, many of which are antimicrobials that impact on polymicrobial community composition. Consequently, quenching QS modulates the environmental impact of P.... Read More

Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes (2013)
Journal Article
Lui, L. T., Xue, X., Sui, C., Brown, A., Pritchard, D. I., Halliday, N., …Alexander, C. (2013). Bacteria clustering by polymers induces the expression of quorum sense controlled phenotypes. Nature Chemistry, 5(12), doi:10.1038/nchem.1793. ISSN 1755-4330

Bacteria deploy a range of chemistries to regulate their behaviour and respond to their environment. Quorum sensing is one mean by which bacteria use chemical reactions to modulate pre-infection behaviour such as surface attachment. Polymers that can... Read More