Skip to main content

Research Repository

Advanced Search

All Outputs (12)

Does cannabis use predict psychometric schizotypy via aberrant salience? (2020)
Journal Article
O'Tuathaigh, C. M., Dawes, C., Bickerdike, A., Duggan, E., O'Neill, C., Waddington, J. L., & Moran, P. M. (2020). Does cannabis use predict psychometric schizotypy via aberrant salience?. Schizophrenia Research, 220, 194-200. https://doi.org/10.1016/j.schres.2020.03.021

Cannabis can induce acute psychotic symptoms in healthy individuals and exacerbate pre-existing psychotic symptoms in patients with schizophrenia. Inappropriate salience allocation is hypothesised to be central to the association between dopamine dys... Read More about Does cannabis use predict psychometric schizotypy via aberrant salience?.

Olfactory threshold selectively predicts positive psychometric schizotypy (2019)
Journal Article
Mathur, N., Dawes, C., & Moran, P. (2019). Olfactory threshold selectively predicts positive psychometric schizotypy. Schizophrenia Research, 209, 80-87. https://doi.org/10.1016/j.schres.2019.05.014

Olfactory impairment might be useful as a non-invasive pre-morbid biological marker of psychosis. People with schizophrenia show consistent impairments, but an association between olfaction and schizotypy in non-clinical populations is inconclusive a... Read More about Olfactory threshold selectively predicts positive psychometric schizotypy.

Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies (2017)
Journal Article
O'Tuathaigh, C., Moran, P., Zhen, X., & Waddington, J. (in press). Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies. British Journal of Pharmacology, 174(19), https://doi.org/10.1111/bph.13938

The presence and severity of cognitive symptoms, including working memory, executive dysfunction and attentional impairment, contributes materially to functional impairment in schizophrenia. Cognitive symptoms have proven resistant to both first- and... Read More about Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies.

Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice (2017)
Journal Article
Oyegbami, O., Collins, H. M., Pardon, M., Ebling, F. J., Heery, D. M., & Moran, P. M. (2017). Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice. Current Alzheimer Research, 14(8), 850-860. https://doi.org/10.2174/1567205014666170317113159

In addition to cognitive decline, Alzheimer’s disease (AD) is also characterized by agitation and disruptions in activity and sleep. These symptoms typically occur in the evening or at night and have been referred to as ‘sundowning’. These symptoms a... Read More about Abnormal clock gene expression and locomotor activity rhythms in two month-old female APPSwe/PS1dE9 mice.

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPAR?) are disrupted by retinal disease-associated mutations (2017)
Journal Article
Fulton, J., Mazumder, B., Whitchurch, J., Monteiro, C. J., Collins, H. M., Chan, C. M., …Heery, D. M. (2017). Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPARγ) are disrupted by retinal disease-associated mutations. Cell Death and Disease, 8, Article e2677. https://doi.org/10.1038/cddis.2017.98

Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the Nuclear Receptor (NR) superfamily of transcription factors. We assessed... Read More about Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor (PPAR?) are disrupted by retinal disease-associated mutations.

Specialised information processing deficits and distinct metabolomics profiles following TM-domain disruption of Nrg1 (2017)
Journal Article
O'Tuathaigh, C., Mathur, N., O'Callaghan, M., MacIntyre, L., Harvey, R., Lai, D., …Moran, P. M. (2017). Specialised information processing deficits and distinct metabolomics profiles following TM-domain disruption of Nrg1. Schizophrenia Bulletin, 43(5), 1100-1113. https://doi.org/10.1093/schbul/sbw189

© The Author 2017. Although there is considerable genetic and pathologic evidence for an association between neuregulin 1 (NRG1) dysregulation and schizophrenia, the underlying molecular and cellular mechanisms remain unclear. Mutant mice containing... Read More about Specialised information processing deficits and distinct metabolomics profiles following TM-domain disruption of Nrg1.

Gene × environment interactions in schizophrenia: evidence from genetic mouse models (2016)
Journal Article
Moran, P. M., Stokes, J., Marr, J., Bock, G., Desbonnet, L., Waddington, J., & O'Tuathaigh, C. (2016). Gene × environment interactions in schizophrenia: evidence from genetic mouse models. Neural Plasticity, 2016, 1-23. https://doi.org/10.1155/2016/2173748

The study of gene × environment, as well as epistatic interactions in schizophrenia, has provided important insight into the complex etiopathologic basis of schizophrenia. It has also increased our understanding of the role of susceptibility genes in... Read More about Gene × environment interactions in schizophrenia: evidence from genetic mouse models.

Enhanced latent inhibition in high schizotypy individuals (2015)
Journal Article
Granger, K. T., Moran, P. M., Buckley, M. G., & Haselgrove, M. (2016). Enhanced latent inhibition in high schizotypy individuals. Personality and Individual Differences, 91, https://doi.org/10.1016/j.paid.2015.11.040

Latent inhibition refers to a retardation in learning about a stimulus that has been rendered familiar by non-reinforced preexposure, relative to a non-preexposed stimulus. Latent inhibition has been shown to be inversely correlated with schizotypy,... Read More about Enhanced latent inhibition in high schizotypy individuals.

Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms? (2014)
Journal Article
O'Callaghan, M., Bay-Richter, C., O’ Tuathaigh, C. M., Heery, D. M., Waddington, J., & Moran, P. M. (2014). Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?. Journal of Psychopharmacology, 28(10), https://doi.org/10.1177/0269881114544774

Whether the dopamine Drd-2 receptor is necessary for the behavioural action of antipsychotic drugs is an important question, as Drd-2 antagonism is responsible for their debilitating motor side effects. Using Drd-2 null mice (Drd2 -/-) it has previou... Read More about Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?.

A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors (2013)
Journal Article
Chan, C. M., Fulton, J., Montiel-Duarte, C., Collins, H. M., Bharti, N., Wadelin, F. R., …Heery, D. M. (2013). A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Research, 41(21), https://doi.org/10.1093/nar/gkt761

Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates... Read More about A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.

Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia (2012)
Journal Article
Moran, P. M., Rouse, J. L., Cross, B., Corcoran, R., & Schürmann, M. (2012). Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia. PLoS ONE, 7(8), Article e43905. https://doi.org/10.1371/journal.pone.0043905

The following study used 3-T functional magnetic resonance imaging (fMRI) to investigate the neural signature of Kamin blocking. Kamin blocking is an associative learning phenomenon seen where prior association of a stimulus (A) with an outcome block... Read More about Kamin blocking is associated with reduced medial-frontal gyrus activation: implications for prediction error abnormality in schizophrenia.