Research Repository

See what's under the surface


Intestinal organoids for modelling intestinal development and disease (2018)
Journal Article
Fair, K. L., Colquhoun, J., & Hannan, N. R. F. (2018). Intestinal organoids for modelling intestinal development and disease. Philosophical Transactions B: Biological Sciences, 373(1750), doi:10.1098/rstb.2017.0217

Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific mod... Read More

Generation of Hepatocytes from Pluripotent Stem Cells for Drug Screening and Developmental Modeling. (2014)
Journal Article
GieseckIII, R. L., Vallier, L., & Hannan, N. (2015). Generation of Hepatocytes from Pluripotent Stem Cells for Drug Screening and Developmental Modeling. Methods in Molecular Biology, 1250, 123-142. doi:10.1007/978-1-4939-2074-7_9

Hepatocytes produced from the differentiation of human pluripotent stem cells can be used to study human development and liver disease, to investigate the toxicological response of novel drug candidates, and as an alternative source of primary cells... Read More

Disease modeling using human induced pluripotent stem cells: lessons from the liver (2014)
Journal Article
Gieseck III, R. L., Colquhoun, J., & Hannan, N. (2015). Disease modeling using human induced pluripotent stem cells: lessons from the liver. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1851(1), 76-89. doi:10.1016/j.bbalip.2014.05.010

Human pluripotent stem cells (hPSCs) have the capacity to differentiate into any of the hundreds of distinct cell types that comprise the human body. This unique characteristic has resulted in considerable interest in the field of regenerative medici... Read More