Research Repository

See what's under the surface


VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis (2018)
Journal Article
Beazley-Long, N., Moss, C. E., Ashby, W. R., Bestall, S. M., Almahasneh, F., Durrant, A. M., …Donaldson, L. F. (2018). VEGFR2 promotes central endothelial activation and the spread of pain in inflammatory arthritis. Brain, Behavior, and Immunity, 74, 49-67. doi:10.1016/j.bbi.2018.03.012

Chronic pain can develop in response to conditions such as inflammatory arthritis. The central mechanisms underlying the development and maintenance of chronic pain in humans are not well elucidated although there is evidence for a role of microglia... Read More

Alternative RNA splicing: contribution to pain and potential therapeutic strategy (2016)
Journal Article
Donaldson, L. F., & Beazley-Long, N. (in press). Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug Discovery Today, doi:10.1016/j.drudis.2016.06.017. ISSN 1359-6446

Since the sequencing of metazoan genomes began, it has become clear that the number of expressed proteins far exceeds the number of genes. It is now estimated that greater up to 98% of human genes give rise to multiple proteins through alternative pr... Read More

Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration (2015)
Journal Article
Hulse, R. P., Beazley-Long, N., Ved, N., Bestall, S. M., Riaz, H., Singhal, P., …Donaldson, L. F. (2015). Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration. Clinical Science, 129(8), doi:10.1042/CS20150124. ISSN 0143-5221

Diabetic peripheral neuropathy affects up to half of diabetic patients. This neuronal damage leads to sensory disturbances, including allodynia and hyperalgesia. Many growth factors have been suggested as useful treatments for prevention of neurodege... Read More