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Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice (2019)
Journal Article
Askar, B., Higgins, J., Barrow, P., & Foster, N. (2020). Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice. Cytokine, 125, Article 154787. https://doi.org/10.1016/j.cyto.2019.154787

© 2019 Elsevier Ltd Studies have shown that administration of vasoactive intestinal peptide (VIP) in mice rescues them from lethal endotoxaemia and that this is correlated with decreased concentration of inflammatory cytokines. VIP has, therefore, be... Read More about Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice.

A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response (2018)
Journal Article
Tang, Y., Foster, N., Jones, M. A., & Barrow, P. A. (2018). A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response. Infection and Immunity, 86(8), Article e00307-18. https://doi.org/10.1128/IAI.00307-18

Salmonella enterica infection affects a wide range of animals and human and a small number of serovars cause typhoid-like infections, one characteristic of which is persistent infection in convalescents. The avian specific serovar S Pullorum produces... Read More about A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response.

Molecular approaches to the diagnosis and monitoring of production diseases in pigs (2017)
Journal Article
Giles, T. A., Belkhiri, A., Barrow, P. A., & Foster, N. (2017). Molecular approaches to the diagnosis and monitoring of production diseases in pigs. Research in Veterinary Science, 114, https://doi.org/10.1016/j.rvsc.2017.05.016

Production disease in pigs is caused by a variety of different pathogens, mainly enteric and respiratory and can result in significant economic loss. Other factors such as stress, poor husbandry and nutrition can also contribute to an animal's suscep... Read More about Molecular approaches to the diagnosis and monitoring of production diseases in pigs.

IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation (2016)
Journal Article
Penha, R., Higgins, J., Mutamba, S., Barrow, P., Mahida, Y. R., & Foster, N. (2016). IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation. Cytokine, 85, https://doi.org/10.1016/j.cyto.2016.05.023

We show that IL-36R is expressed by T (CD4+ and CD8+) and B (CD19+) lymphocytes in human blood and also by CD4+ T lymphocytes in the intestinal lamina propria. IL-36R protein was mostly stored in the cytoplasm of CD4 lymphocytes and B cells, during s... Read More about IL-36 receptor is expressed by human blood and intestinal T lymphocytes and is dose–dependently activated via IL-36β and induces CD4+ lymphocyte proliferation.

Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs (2015)
Journal Article
Foster, N., Richards, L., Higgins, J., Kanellos, T., & Barrow, P. (2016). Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs. Research in Veterinary Science, 104, https://doi.org/10.1016/j.rvsc.2015.12.013

We show that oral inoculation of 14 day old conventional piglets with a rough attenuated Salmonella enterica serovar Infantis 1326/28?r (serogroup C1), 24 h prior to oral challenge with S. enterica serovar Typhimurium 4/74 (serogroup B), resulted in... Read More about Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs.

Vasoactive intestinal peptide (VIP) differentially affects inflammatory immune responses in human monocytes infected with viable Salmonella or stimulated with LPS (2015)
Journal Article
Askar, B. A., Ibrahim, H., Barrow, P., & Foster, N. (2015). Vasoactive intestinal peptide (VIP) differentially affects inflammatory immune responses in human monocytes infected with viable Salmonella or stimulated with LPS. Peptides, 71, https://doi.org/10.1016/j.peptides.2015.06.009

We compared the effect of VIP on human blood monocytes infected with Salmonella typhimurium 4/74 or stimulated with LPS. VIP (10?7 M) increased monocyte viability by 24% and 9% when cultured for 24 h with 4/74 or Salmonella LPS (100 ng/ml), respectiv... Read More about Vasoactive intestinal peptide (VIP) differentially affects inflammatory immune responses in human monocytes infected with viable Salmonella or stimulated with LPS.

IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c (2015)
Journal Article
Higgins, J., Mutamba, S., Mahida, Y. R., Barrow, P., & Foster, N. (2015). IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c. Human Immunology, 76(4), https://doi.org/10.1016/j.humimm.2015.01.012

We show that IL-36? induced maturation of human MDDCs and stimulated differentiation of IFN-? producing (Type 1) CD3+ lymphocytes but was not as effective as IL-36? in doing so. For the first time, we also show that IL-36? induced expression of CD14... Read More about IL-36? induces maturation of Th1-inducing human MDDC and synergises with IFN-? to induce high surface expression of CD14 and CD11c.

Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs (2014)
Journal Article
Naqid, I. A., Owen, J. P., Maddison, B. C., Gardner, D. S., Foster, N., Tchorzewska, M., …Gough, K. C. (2015). Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs. Animal Feed Science and Technology, 201, 57-65. https://doi.org/10.1016/j.anifeedsci.2014.12.005

Salmonellosis causes significant economic losses to the pig industry and contaminated pork products are an important source of Salmonella for humans. The EU ban on the use of antibiotic growth promoters in pig production, and the emergence of antibio... Read More about Prebiotic and probiotic agents enhance antibody-based immune responses to Salmonella Typhimurium infection in pigs.

Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy (2013)
Journal Article
Rauch, C., Ibrahim, H., & Foster, N. (2013). Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy. Journal of cancer therapeutics & research, 2, Article 20. https://doi.org/10.7243/2049-7962-2-20

Despite great medical advancement in the treatment of cancer, cancer remains a disease of global significance. Chemotherapeutics can be very expensive and drain medical resources at a national level and in some cases the cost of treatment is so great... Read More about Membranes, molecules and biophysics: enhancing monocyte derived dendritic cell (MDDC) immunogenicity for improved anti-cancer therapy.

Veterinary students' usage and perception of video teaching resources (2011)
Journal Article
Roshier, A. L., Foster, N., & Jones, M. A. (2011). Veterinary students' usage and perception of video teaching resources. BMC Medical Education, 11(Januar), Article 13. https://doi.org/10.1186/1472-6920-11-1

Background: The purpose of our study was to use a student-centred approach to develop an online video learning resource (called 'Moo Tube') at the School of Veterinary Medicine and Science, University of Nottingham, UK and also to provide guidance fo... Read More about Veterinary students' usage and perception of video teaching resources.