Research Repository

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Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis (2018)
Journal Article
Drury, R. J., Falah, Y., Gowland, P. A., Evangelou, N., Bright, M. G., & Francis, S. T. (2018). Ultra-high-field arterial spin labeling MRI for non-contrast assessment of cortical lesion perfusion in multiple sclerosis. European Radiology, ISSN 0938-7994

Objectives Assess the feasibility of using an optimised ultra-high-field high-spatial-resolution low-distortion ASL MRI acquisition to measure focal haemodynamic pathology in cortical lesions (CLs) in Multiple Sclerosis (MS). Methods Twelve... Read More

Multiparametric measurement of cerebral physiology using calibrated fMRI (2017)
Journal Article
Bright, M. G., Croal, P. L., Blockley, N. P., & Bulte, D. P. (2017). Multiparametric measurement of cerebral physiology using calibrated fMRI. NeuroImage, doi:10.1016/j.neuroimage.2017.12.049

The ultimate goal of calibrated fMRI is the quantitative imaging of oxygen metabolism (CMRO2), and this has been the focus of numerous methods and approaches. However, one underappreciated aspect of this quest is that in the drive to measure CMRO2, m... Read More

Potential pitfalls when denoising resting state fMRI data using nuisance regression (2016)
Journal Article
Bright, M. G., Tench, C. R., & Murphy, K. (2017). Potential pitfalls when denoising resting state fMRI data using nuisance regression. NeuroImage, 154, (159-168). doi:10.1016/j.neuroimage.2016.12.027. ISSN 1053-8119

In resting state fMRI, it is necessary to remove signal variance associated with noise sources, leaving cleaned fMRI time-series that more accurately reflect the underlying intrinsic brain fluctuations of interest. This is commonly achieved through n... Read More