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Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI (2020)
Journal Article
Petersen, K. K., Iwabuchi, S. J., Xing, Y., Cottam, W. J., Drabek, M. M., Tadjibaev, A., …Auer, D. P. (2020). Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI. PAIN, 1. https://doi.org/10.1097/j.pain.0000000000001829

Chronic musculoskeletal pain is a common problem globally. Current evidence suggests that maladapted central pain pathways are associated with pain chronicity following e.g. post-operative pain after knee replacement. Other factors such as low mood,... Read More about Brain perfusion patterns are altered in chronic knee pain: a spatial covariance analysis of arterial spin labelling MRI.

Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis (2020)
Journal Article
Fernandes, G. S., Parekh, S. M., Moses, J. P., Fuller, C. W., Scammell, B. E., Batt, M. E., …Doherty, M. (2020). Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis. Sports Medicine, https://doi.org/10.1007/s40279-019-01255-x

© 2020, The Author(s). Background: The long-term risk from knee intra-articular (KIA) injections in professional athletes such as ex-footballers remains unknown. The use of KIA injections is controversial and remains anecdotally prolific as it is per... Read More about Intra-articular Injection Administration in UK Ex-professional Footballers During Their Playing Careers and the Association with Post-career Knee Osteoarthritis.

Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M., Valdes, A., Townsend, N., Mallen, C., Zhang, W., …Abhishek, A. (2019). Do β-adrenoreceptor blocking drugs associate with reduced risk of symptomatic osteoarthritis and total joint replacement in the general population?: A primary-care based prospective cohort study using the Clinical Practice Research Datalink. BMJ Open, 9(8), doi:10.1136/bmjopen-2019-032050

Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis (2019)
Journal Article
Goh, S., Persson, M. S., Stocks, J., Hou, Y., Lin, J., Hall, M. C., …Zhang, W. (2019). Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis. Annals of Physical and Rehabilitation Medicine, 62(5), 356-365. https://doi.org/10.1016/j.rehab.2019.04.006

Background. Exercise is an effective treatment for osteoarthritis. However, the effect may vary from one patient (or study) to another. Objective. To evaluate the efficacy of exercise and its potential determinants for pain, function, performance,... Read More about Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: a systematic review and meta-analysis.

Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data (2019)
Presentation / Conference
Stocks, J., Persson, M., van Middelkoop, M., Bierma-Zeinstra, S., Runhaar, J., Sawitzke, A., …Zhang, W. (2019, May). Identifying predictors of placebo response in osteoarthritis clinical trials of three agents with different routes of delivery: a meta-analysis using individual patient data. Presented at 2019 World Congress on Osteoarthritis

Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink (2019)
Journal Article
Nakafero, G., Grainge, M. J., Myles, P., Mallen, C. D., Zhang, W., Doherty, M., …Abhishek, A. (2019). Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 78(8), 1122-1126. doi:10.1136/annrheumdis-2019-215086

Objectives To examine the association between inactivated influenza vaccine (IIV) administration and primary care consultation for joint pain, rheumatoid arthritis (RA) flare, corticosteroid prescription, vasculitis, and unexplained fever in people w... Read More about Association between inactivated influenza vaccine and primary care consultations for autoimmune rheumatic disease flares: a self-controlled case series study using data from the Clinical Practice Research Datalink.

Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study (2019)
Journal Article
Parekh, S. M., Fernandes, G. S., Moses, J. P., Fuller, C. W., Scammell, B. E., Batt, M. E., …Doherty, M. (2019). Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study. Clinical Journal of Sport Medicine, 1-8. https://doi.org/10.1097/JSM.0000000000000742

Objective: To determine risk factors for three knee osteoarthritis (KOA) outcomes, knee pain (KP), radiographic KOA (RKOA) and total knee replacement (TKR), in professional footballers. Design: This was a cross-sectional study involving a postal que... Read More about Risk Factors for Knee Osteoarthritis in Retired Professional Footballers: A Cross-Sectional Study.

Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis (2019)
Journal Article
Goh, S., Persson, M. S., Stocks, J., Hou, Y., Welton, N. J., Lin, J., …Zhang, W. (2019). Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis. Sports Medicine, 49(5), 743–761. doi:10.1007/s40279-019-01082-0

Background: Guidelines recommend exercise as a core treatment for osteoarthritis (OA). However, it is unclear which type of exercise is most effective, leading to inconsistency between different recommendations. Objectives: To investigate the rel... Read More about Relative efficacy of different exercises for pain, function, performance and quality of life in knee and hip osteoarthritis: systematic review and network meta-analysis.

Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II) (2019)
Journal Article
Chinchilla, S. P., Doherty, M., & Abhishek, A. (2019). Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II). Rheumatology, 58(8), 1378-1382. doi:10.1093/rheumatology/key446

Objectives: To examine the predictive validity of the Gout Activity Score (GAS), its’ correlation with the Gout Impact Scale (GIS), and their sensitivity to change. Methods: Data from a clinical trial in which participants with ≥1 gout flare in th... Read More about Gout Activity Score has predictive validity and is sensitive to change: results from the Nottingham Gout Treatment Trial (Phase II).

Temporal relationships between systemic lupus erythematosus and comorbidities (2018)
Journal Article
Kuo, C., Chou, I., Rees, F., Grainge, M. J., Lanyon, P., Davenport, G., …Doherty, M. (2019). Temporal relationships between systemic lupus erythematosus and comorbidities. Rheumatology, 58(5), 840-848. doi:10.1093/rheumatology/key335

Objective To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality. Methods We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities... Read More about Temporal relationships between systemic lupus erythematosus and comorbidities.

Thresholds of ultrasound synovial abnormalities for knee osteoarthritis: a cross sectional study in the general population (2018)
Journal Article
Sarmanova, A., Hall, M., Fernandes, G., Valdes, A., Walsh, D., Doherty, M., & Zhang, W. (2019). Thresholds of ultrasound synovial abnormalities for knee osteoarthritis: a cross sectional study in the general population. Osteoarthritis and Cartilage, 27(3), 435-443. doi:10.1016/j.joca.2018.09.018

Objective To establish “normal” ranges for synovial thickness and effusion detected by ultrasound (US) and to determine cut-offs associated with knee pain (KP) and radiographic knee osteoarthritis (RKOA) in the community. Methods 147 women a... Read More about Thresholds of ultrasound synovial abnormalities for knee osteoarthritis: a cross sectional study in the general population.

Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care (2018)
Journal Article
Latif, Z. P., Nakafero, G., Jenkins, W., Doherty, M., & Abhishek, A. (2019). Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care. Joint Bone Spine, 86(3), 357-362. doi:10.1016/j.jbspin.2018.10.008

Objectives To explore patient perception of the role of a nurse-led complex package of care in facilitating engagement with urate-lowering therapies (ULTs) in the management of gout. Methods Thirty people who had participated in a randomised control... Read More about Implication of nurse intervention on engagement with urate-lowering drugs: a qualitative study of participants in a RCT of nurse led care.

Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial (2018)
Journal Article
Doherty, M., Jenkins, W., Richardson, H., Sarmanova, A., Abhishek, A., Ashton, D., …Zhang, W. (2018). Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial. Lancet, 392(10156), 1403-1412. doi:10.1016/S0140-6736(18)32158-5

Background: In the UK gout management is suboptimal, only 40% of patients receiving urate-lowering therapy (ULT), usually without titration to a target serum urate (SU) level. Nurses successfully manage many diseases in primary care. This trial compa... Read More about Efficacy and cost-effectiveness of nurse-lead care involving education and engagement of patients and a treat-to-target urate-lowering strategy versus usual care for gout: a randomised controlled trial.