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Using Raman spectroscopy to improve hyperpolarized noble gas production for clinical lung imaging techniques (2017)
Book
Birchall, J., Whiting, N., Skinner, J., Barlow, M. J., & Goodson, B. M. (2017). Using Raman spectroscopy to improve hyperpolarized noble gas production for clinical lung imaging techniques. In Raman spectroscopy and applications, 247-268. London: InTech. doi:10.5772/65114

Spin-exchange optical pumping (SEOP) can be used to “hyperpolarize” 129Xe for human lung MRI. SEOP involves transfer of angular momentum from light to an alkali metal (Rb) vapor, and then onto 129Xe nuclear spins during collisions; collisions between... Read More

Hyperpolarization methods for MRS (2016)
Book
Goodson, B. M., Whiting, N., Coffey, A. M., Nikolaou, P., Shi, F., Gust, B. M., …Chekmenev, E. Y. (2016). Hyperpolarization methods for MRS. In P. A. Bottomley, & J. R. Griffiths (Eds.), Handbook of Magnetic Resonance Spectroscopy In Vivo: MRS Theory, Practice and Applications, 557-574. London: Wiley. doi:10.1002/9780470034590.emrstm1457

This chapter covers the fundamental principles and practice of NMR hyperpolarization techniques, which are proving useful for in vivo Magnetic Resonance Spectroscopy (MRS) studies of metabolism in animal models, and clinical trials with hyper-enhance... Read More

Temperature-ramped 129Xe spin-exchange optical pumping (2014)
Journal Article
Nikolaou, P., Coffey, A. M., Barlow, M. J., Rosen, M. S., Goodson, B. M., & Chekmenev, E. Y. (2014). Temperature-ramped 129Xe spin-exchange optical pumping. Analytical Chemistry, 86(16), 8206-8212. doi:10.1021/ac501537w

We describe temperature-ramped spin-exchange optical pumping (TR-SEOP) in an automated high-throughput batch-mode 129Xe hyperpolarizer utilizing three key temperature regimes: (i) “hot”—where the 129Xe hyperpolarization rate is maximal, (ii) “warm”—w... Read More