All Outputs (4)

Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes (2016)
Journal Article
Naranjo-Ortíz, M. A., Brock, M., Brunke, S., Hube, B., Marcet-Houben, M., & Gabaldón, T. (2016). Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.02001

Analysis of the growing number of available fully-sequenced genomes has shown that Horizontal Gene Transfer (HGT) in eukaryotes is more common than previously thought. It has been proposed that genes with certain functions may be more prone to HGT th... Read More about Widespread inter- and intra-domain horizontal gene transfer of d-amino acid metabolism enzymes in eukaryotes.

Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens (2016)
Journal Article
Kalleda, N., Amich, J., Arslan, B., Poreddy, S., Mattenheimer, K., Mokhtari, Z., …Beilhack, A. (2016). Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens. Frontiers in Microbiology, 7, https://doi.org/10.3389/fmicb.2016.01107

Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. In contrast, A. fumigatus causes devastating infec... Read More about Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens.

A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress (2016)
Journal Article
Geib, E., Gressler, M., Viediernikova, I., Hillmann, F., Jacobsen, I. D., Nietzsche, S., …Brock, M. (2016). A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress. Cell Chemical Biology, 23(5), https://doi.org/10.1016/j.chembiol.2016.03.014

Pro- and eukaryotes produce melanin for protection from environmental stress or as virulence determinant. The human pathogenic fungus Aspergillus fumigatus and related Ascomycetes produce dihydroxynaphthalene (DHN) melanin in conidia, which is essent... Read More about A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress.

Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge (2016)
Journal Article
Savers, A., Rasid, O., Parlato, M., Brock, M., Jouvion, G., Ryffel, B., …Ibrahim-Granet, O. (2016). Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge. PLoS ONE, 11(4), Article e0153829. https://doi.org/10.1371/journal.pone.0153829

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge... Read More about Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge.