Research Repository

See what's under the surface


Don't blame it on the sunshine, don't blame it on the moonlight, don't blame it on good times, blame it on the sociocultural factors (2019)
Journal Article
Jepsen, P., & Grainge, M. J. (2019). Don't blame it on the sunshine, don't blame it on the moonlight, don't blame it on good times, blame it on the sociocultural factors. Hepatology, doi:10.1002/hep.30547

In this issue of Hepatology, Ventura‐Cots and colleagues present their study arguing that colder weather and fewer sunlight hours increase alcohol consumption and thus cause alcoholic cirrhosis (1). “Causality” is a key concept for this study. A rece... Read More

Temporal relationships between systemic lupus erythematosus and comorbidities (2018)
Journal Article
Kuo, C., Chou, I., Rees, F., Grainge, M. J., Lanyon, P., Davenport, G., …Doherty, M. (2018). Temporal relationships between systemic lupus erythematosus and comorbidities. Rheumatology, doi:10.1093/rheumatology/key335

Objective To examine the burden of comorbidities prior to and after the diagnosis of SLE and its impact on mortality. Methods We identified 1605 incident cases of SLE and 6284 matched controls from the UK primary care. The risks of comorbidities... Read More

Visual inspection for the diagnosis of cutaneous melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Grainge, M. J., Chuchu, N., Ferrante di Ruffano, L., Matin, R. N., …Williams, H. C. (2018). Visual inspection for the diagnosis of cutaneous melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD013194

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. History-taking and visual inspection of a suspicious... Read More

Dermoscopy, with and without visual inspection, for the diagnosis of melanoma in adults (2018)
Journal Article
Dinnes, J., Deeks, J. J., Chuchu, N., Ferrante di Ruffano, L., Matin, R. N., Thomson, D. R., …Williams, H. C. (2018). Dermoscopy, with and without visual inspection, for the diagnosis of melanoma in adults. Cochrane Database of Systematic Reviews, 2018(12), doi:10.1002/14651858.CD011902.pub2

Background: Melanoma has one of the fastest rising incidence rates of any cancer. It accounts for a small percentage of skin cancer cases but is responsible for the majority of skin cancer deaths. Although history-taking and visual inspection of a su... Read More

Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort (2018)
Journal Article
Quarpong, W., Card, T. R., West, J., Solaymani-Dodaran, M., Logan, R. F., & Grainge, M. J. (2018). Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort. United European Gastroenterology Journal, doi:10.1177/2050640618814662

Background: Few studies have determined the very long-term mortality risks in adult and childhood-diagnosed coeliac disease. Objective: We quantified mortality risks in coeliac disease and determined whether age at diagnosis, or time following di... Read More

Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families (2018)
Journal Article
Kuo, C., Chou, I., Grainge, M., Luo, S., See, L., Yu, K., …Valdes, A. (2018). Familial aggregation and heritability of type 1 diabetes mellitus and coaggregation of chronic diseases in affected families. Clinical Epidemiology, 10, 1447-1455. doi:10.2147/clep.s172207

Purpose: To estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks. Patients and methods: This popula... Read More

The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity (2018)
Journal Article
Chu, T. P. C., Grainge, M. J., & Card, T. R. (2018). The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity. Alimentary Pharmacology and Therapeutics, doi:10.1111/apt.15010. ISSN 0269-2813

Background: Inflammatory bowel disease (IBD) increases the risk of venous thromboembolism. Aim: To determine when patients are at high risk of thromboembolic events, including after major surgery, and to guide timing of thromboprophylaxis. Methods:... Read More

The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink (2018)
Journal Article
Royle, J. G., Lanyon, P. C., Grainge, M. J., Abhishek, A., & Pearce, F. A. (2018). The incidence, prevalence and survival of systemic sclerosis in the UK Clinical Practice Research Datalink. Clinical Rheumatology, 37(8), (2103–2111). ISSN 0770-3198

Objective: To estimate the incidence, prevalence and survival of systemic sclerosis in the United Kingdom. Methods: We conducted a historical cohort study using data from the Clinical Practice Research Datalink (CPRD). We calculated the incidence an... Read More

All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis (2018)
Journal Article
Abdul-Rahman, A., Card, T. R., Grainge, M. J., & Fleming, K. M. (in press). All-cause and cause-specific mortality rates of patients treated for alcohol use disorders: a meta-analysis. Substance Abuse, doi:10.1080/08897077.2018.1475318. ISSN 0889-7077

Background Although alcohol use disorders (AUD) are known to increase the relative risk of all-cause and some cause-specific mortalities, the absolute mortality rates of the AUD population are unknown. Such knowledge would benefit planners of the pr... Read More

Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis (2017)
Journal Article
Khan, U. T., Walker, A. J., Baig, S., Card, T. R., Kirwan, C. C., & Grainge, M. J. (2017). Venous thromboembolism and mortality in breast cancer: cohort study with systematic review and meta-analysis. BMC Cancer, 17(747), doi:10.1186/s12885-017-3719-1. ISSN 1471-2407

Background Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in breast cancer patients is conflicting. We present data from a large cohort of... Read More

The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis (2017)
Journal Article
Osinubi, O., Grainge, M. J., Ahmed, A., Batchelor, J. M., Grindlay, D., Thompson, A., & Ratib, S. (2018). The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis. British Journal of Dermatology, 178(4), doi:10.1111/bjd.16049. ISSN 0007-0963

Background: Vitiligo is a chronic disorder causing skin depigmentation with global prevalence varying from 0.2 to 1.8%. UK guidelines recommend assessment of psychological state during clinical evaluation of vitiligo. However, the prevalence of psych... Read More

Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study (2017)
Journal Article
Pearce, F. A., Hubbard, R., Grainge, M. J., Watts, R. A., Abhishek, A., & Lanyon, P. C. (in press). Can granulomatosis with polyangiitis be diagnosed earlier in primary care? A case-control study. QJM: An International Journal of Medicine, doi:10.1093/qjmed/hcx194. ISSN 1460-2725

Background: People with granulomatosis with polyangiitis (GPA) commonly describe long delays before diagnosis. Aim: To study the natural history of GPA prior to diagnosis using primary care data, and determine whether clinical features could be iden... Read More

Alcohol consumption and risk of common cancers: evidence from a cohort of adults from the United Kingdom (2017)
Journal Article
Betts, G., Ratschen, E., Opazo-Breton, M., & Grainge, M. J. (in press). Alcohol consumption and risk of common cancers: evidence from a cohort of adults from the United Kingdom. Journal of Public Health, doi:10.1093/pubmed/fdx123. ISSN 1741-3842

Background: Recent guidelines from the United Kingdom recommend that men and women should drink no more than 14 units of alcohol per week. This recommendation takes into account the link between alcohol and several cancers; however, there is a dearth... Read More

Drugs for discoid lupus erythematosus (2017)
Journal Article
Jessop, S., Whitelaw, D. A., Grainge, M. J., & Jayasekera, P. (in press). Drugs for discoid lupus erythematosus. Cochrane Database of Systematic Reviews, 5, doi:10.1002/14651858.CD002954.pub3. ISSN 1469-493X

BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. Thi... Read More

Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study (2017)
Journal Article
Abhishek, A., Doherty, M., Kuo, C., Mallen, C. D., Zhang, W., & Grainge, M. J. (2017). Rheumatoid arthritis is getting less frequent—results of a nationwide population-based cohort study. Rheumatology, 56(5), doi:10.1093/rheumatology/kew468. ISSN 1462-0332

Objectives: The objectives of this study were to examine changes in incidence and prevalence of RA between 1990 and 2014, and to explore if there is any geographic variation in incidence and prevalence of RA in the UK Methods: Design Prospective... Read More