Research Repository

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Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project (2018)
Journal Article
Bastiani, M., Andersson, J. L., Cordero-Grande, L., Murgasova, M., Hutter, J., Price, A. N., …Sotiropoulos, S. N. (2019). Automated processing pipeline for neonatal diffusion MRI in the developing Human Connectome Project. NeuroImage, 185, 750-763. doi:10.1016/j.neuroimage.2018.05.064

The developing Human Connectome Project is set to create and make available to the scientific community a 4-dimensional map of functional and structural cerebral connectivity from 20 to 44 weeks post-menstrual age, to allow exploration of the genetic... Read More

A gyral coordinate system predictive of fibre orientations (2018)
Journal Article
Cottaar, M., Bastiani, M., Chen, C., Dikranian, K., Van Essen, D., Behrens, T. E., …Jbabdi, S. (2018). A gyral coordinate system predictive of fibre orientations. NeuroImage, 176, doi:10.1016/j.neuroimage.2018.04.040

When axonal fibres approach or leave the cortex, their trajectories tend to closely follow the cortical convolutions. To quantify this tendency, we propose a three-dimensional coordinate system based on the gyral geometry. For every voxel in the brai... Read More

The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction (2018)
Journal Article
Makropoulos, A., Robinson, E. C., Schuh, A., Wright, R., Fitzgibbon, S., Bozek, J., …Rueckert, D. (2018). The Developing Human Connectome Project: a minimal processing pipeline for neonatal cortical surface reconstruction. NeuroImage, 173, (88-112). doi:10.1101/125526

The Developing Human Connectome Project (dHCP) seeks to create the first 4-dimensional connectome of early life. Understanding this connectome in detail may provide insights into normal as well as abnormal patterns of brain development. Following est... Read More

Time-efficient and flexible design of optimized multishell HARDI diffusion (2017)
Journal Article
Hutter, J., Tournier, J. D., Price, A. N., Cordero-Grande, L., Hughes, E. J., Malik, S., …Hajnal, J. V. (2018). Time-efficient and flexible design of optimized multishell HARDI diffusion. Magnetic Resonance in Medicine, 79(3), 1276-1292. doi:10.1002/mrm.26765

Purpose: Advanced diffusion magnetic resonance imaging benefits from collecting as much data as is feasible but is highly sensitive to subject motion and the risk of data loss increases with longer acquisition times. Our purpose was to create a maxim... Read More

Assessing microstructural substrates of white matter abnormalities: a comparative study using DTI and NODDI (2016)
Journal Article
Timmers, I., Roebroeck, A., Bastiani, M., Jansma, B., Rubio-Gozalbo, E., & Zhang, H. (2016). Assessing microstructural substrates of white matter abnormalities: a comparative study using DTI and NODDI. PLoS ONE, 11(12), doi:10.1371/journal.pone.0167884

Neurite orientation dispersion and density imaging (NODDI) enables more specific characterization of tissue microstructure by estimating neurite density (NDI) and orientation dispersion (ODI), two key contributors to fractional anisotropy (FA). The p... Read More

White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study (2016)
Journal Article
Vogel, K., Timmers, I., Kumar, V., Nickl-Jockschat, T., Bastiani, M., Roebroek, A., …Seitz, J. (2015). White matter microstructural changes in adolescent anorexia nervosa including an exploratory longitudinal study. NeuroImage: Clinical, 11, (614-621). doi:10.1016/j.nicl.2016.04.002

Background Anorexia nervosa (AN) often begins in adolescence, however, the understanding of the underlying pathophysiology at this developmentally important age is scarce, impeding early interventions. We used diffusion tensor imaging (DTI) to inv... Read More

Histological validation of high-resolution DTI in human post mortem tissue (2015)
Journal Article
Seehaus, A., Roebroeck, A., Bastiani, M., Fonseca, L., Bratzke, H., Lori, N., …Galuske, R. (2015). Histological validation of high-resolution DTI in human post mortem tissue. Frontiers in Neuroanatomy, 9, doi:10.3389/fnana.2015.00098

Diffusion tensor imaging (DTI) is amongst the simplest mathematical models available for diffusion magnetic resonance imaging, yet still by far the most used one. Despite the success of DTI as an imaging tool for white matter fibers, its anatomical u... Read More

Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI (2015)
Journal Article
Bastiani, M., & Roebroeck, A. (2015). Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI. Frontiers in Neuroanatomy, 9, doi:10.3389/fnana.2015.00077

The structural architecture and the anatomical connectivity of the human brain show different organizational principles at distinct spatial scales. Histological staining and light microscopy techniques have been widely used in classical neuroanatomic... Read More

Comparative analysis of the macroscale structural connectivity in the macaque and human brain (2014)
Journal Article
Goulas, A., Bastiani, M., Bezgin, G., Uylings, H. B., Roebroeck, A., & Stiers, P. (2014). Comparative analysis of the macroscale structural connectivity in the macaque and human brain. PLoS Computational Biology, 10(3), doi:10.1371/journal.pcbi.1003529. ISSN 1553-734X

The macaque brain serves as a model for the human brain, but its suitability is challenged by unique human features, including connectivity reconfigurations, which emerged during primate evolution. We perform a quantitative comparative analysis of th... Read More

Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging (2013)
Journal Article
Prčkovska, V., Achterberg, H. C., Bastiani, M., Pullens, P., Balmashnova, E., ter Haar Romeny, B. M., …Roebroeck, A. (2012). Optimal short-time acquisition schemes in high angular resolution diffusion-weighted imaging. International Journal of Biomedical Imaging, 2013, doi:10.1155/2013/658583. ISSN 1687-4188

This work investigates the possibilities of applying high-angular-resolution-diffusion-imaging- (HARDI-) based methods in a clinical setting by investigating the performance of non-Gaussian diffusion probability density function (PDF) estimation for... Read More

Human cortical connectome reconstruction from diffusion weighted MRI: the effect of tractography algorithm (2012)
Journal Article
Bastiani, M., Shah, N. J., Goebel, R., & Roebroeck, A. (2012). Human cortical connectome reconstruction from diffusion weighted MRI: the effect of tractography algorithm. NeuroImage, 62(3), (1732-1749). doi:10.1016/j.neuroimage.2012.06.002. ISSN 1053-8119

Reconstructing the macroscopic human cortical connectome by Diffusion Weighted Imaging (DWI) is a challenging research topic that has recently gained a lot of attention. In the present work, we investigate the effects of intra-voxel fiber direction m... Read More