Research Repository

See what's under the surface


Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion (2016)
Journal Article
Hammad, M., Rao, W., Smith, J. G. W., Anderson, D. G., Langer, R., Young, L. E., …Alexander, M. R. (in press). Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion. Biomaterials Science, doi:10.1039/c6bm00214e. ISSN 2047-4830

Improved biomaterials are required for application in regenerative medicine, biosensing, and as medical devices. The response of cells to the chemistry of polymers cultured in media is generally regarded as being dominated by proteins adsorbed to the... Read More

Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation (2015)
Journal Article
Celiz, A. D., Smith, J. G., Patel, A. K., Hook, A. L., Rajamohan, D., George, V. T., …Alexander, M. R. (2015). Discovery of a novel polymer for human pluripotent stem cell expansion and multilineage differentiation. Advanced Materials, 27(27), doi:10.1002/adma.201501351. ISSN 0935-9648

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to... Read More

Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity (2014)
Journal Article
Sanni, O., Chang, C., Anderson, D. G., Langer, R., Davies, M. C., Williams, P. M., …Hook, A. L. (2015). Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity. Advanced Healthcare Materials, 4(5), doi:10.1002/adhm.201400648. ISSN 2192-2640

A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety and resistance to bacteria i... Read More

Materials for stem cell factories of the future (2014)
Journal Article
Celiz, A. D., Smith, J. G., Langer, R., Anderson, D. G., Barrett, D. A., Winkler, D. A., …Alexander, M. R. (in press). Materials for stem cell factories of the future. Nature Materials, 13(6), doi:10.1038/nmat3972. ISSN 1476-1122

The materials community is now identifying polymeric substrates that could permit translation of human pluripotent stem cells (hPSCs) from lab-based research to industrial scale biomedicine. Well defined materials are required to allow cell banking a... Read More

Modelling and prediction of bacterial attachment to polymers (2014)
Journal Article
Epa, V., Hook, A. L., Chang, C., Yang, J., Langer, R., Anderson, D. G., …Winkler, D. A. (2014). Modelling and prediction of bacterial attachment to polymers. Advanced Functional Materials, 24(14), doi:10.1002/adfm.201302877. ISSN 1616-301X

Infection by pathogenic bacteria on implanted and indwelling medical devices during surgery causes large morbidity and mortality worldwide. Attempts to ameliorate this important medical issue have included development of antimicrobial surfaces on mat... Read More

Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays (2013)
Journal Article
Hook, A. L., Chang, C., Yang, J., Atkinson, S., Langer, R., Anderson, D. G., …Alexander, M. R. (2013). Discovery of novel materials with broad resistance to bacterial attachment using combinatorial polymer microarrays. Advanced Materials, 25(18), doi:10.1002/adma.201204936. ISSN 0935-9648

A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available silver hydrogel anti-bacteria... Read More

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces (2012)
Journal Article
Epa, V., Yang, J., Mei, Y., Hook, A. L., Langer, R., Anderson, D. G., …Winkler, D. A. (2012). Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces. Journal of Materials Chemistry, 39(22), doi:10.1039/C2JM34782B. ISSN 0959-9428

Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly... Read More

Combinatorial discovery of polymers resistant to bacterial attachment (2012)
Journal Article
Hook, A. L., Chang, C., Yang, J., Luckett, J., Cockayne, A., Atkinson, S., …Alexander, M. R. (2012). Combinatorial discovery of polymers resistant to bacterial attachment. Nature Biotechnology, 30(9), doi:10.1038/nbt.2316. ISSN 1087-0156

Bacterial attachment and subsequent biofilm formation are key challenges to the long term performance of many medical devices. Here, a high throughput approach coupled with the analysis of surface structure-property relationships using a chemometics... Read More

Strategies for MCR image analysis of large hyperspectral data-sets (2012)
Journal Article
Scurr, D. J., Hook, A. L., Burley, J., Williams, P. M., Anderson, D. G., Langer, R., …Alexander, M. R. (2012). Strategies for MCR image analysis of large hyperspectral data-sets. Surface and Interface Analysis, 45(1), doi:10.1002/sia.5040. ISSN 0142-2421

Polymer microarrays are a key enabling technology for high throughput materials discovery. In this study, multivariate image analysis, specifically multivariate curve resolution (MCR), is applied to the hyperspectral time of flight secondary ion mass... Read More

Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray (2011)
Journal Article
Hook, A. L., Yang, J., Chen, X., Roberts, C. J., Mei, Y., Anderson, D. G., …Davies, M. C. (2011). Polymers with hydro-responsive topography identified using high throughput AFM of an acrylate microarray. Soft Matter, 7, doi:10.1039/c1sm06063e. ISSN 1744-683X

Atomic force microscopy has been applied to an acrylate polymer microarray to achieve a full topographic characterisation. This process discovered a small number of hydro-responsive materials created from monomers with disparate hydrophilicities that... Read More

High throughput methods applied in biomaterial development and discovery (2010)
Journal Article
Hook, A. L., Anderson, D. G., Langer, R., Williams, P., Davies, M. C., & Alexander, M. R. (2010). High throughput methods applied in biomaterial development and discovery. Biomaterials, 31(2), doi:10.1016/j.biomaterials.2009.09.037. ISSN 0142-9612

The high throughput discovery of new materials can be achieved by rapidly screening many different materials synthesised by a combinatorial approach to identify the optimal material that fulfils a particular biomedical application. Here we review the... Read More

High throughput screening for discovery of materials that control stem cell fate
Journal Article
Patel, A. K., Tibbitt, M., Celiz, A. D., Davies, M. C., Langer, R., Denning, C., …Anderson, D. G. (2016). High throughput screening for discovery of materials that control stem cell fate. Current Opinion in Solid State and Materials Science, doi:10.1016/j.cossms.2016.02.002. ISSN 1359-0286

Insights into the complex stem cell niche have identified the cell–material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the oppo... Read More