Research Repository

See what's under the surface


High-throughput miniaturized screening of nanoparticle formation via inkjet printing (2018)
Journal Article
Styliari, I. D., Conte, C., Pearce, A. K., Hüsler, A., Cavanagh, R. J., Limo, M. J., …Taresco, V. (in press). High-throughput miniaturized screening of nanoparticle formation via inkjet printing. Macromolecular Materials and Engineering, doi:10.1002/mame.201800146. ISSN 1438-7492

The self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput method to screen the abilit... Read More

Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans (2017)
Journal Article
Murray, K., Hoad, C. L., Mudie, D. M., Wright, J., Heissam, K., Abrehart, N., …Marciani, L. (2017). Magnetic resonance imaging quantification of fasted state colonic liquid pockets in healthy humans. Molecular Pharmaceutics, 14(8), 2629-2638. doi:10.1021/acs.molpharmaceut.7b00095

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a... Read More

High-throughput spheroid screens using volume, resazurin reduction and acid phosphatase activity (2017)
Book
Ivanov, D. P., Grabowska, A. M., & Garnett, M. C. (in press). High-throughput spheroid screens using volume, resazurin reduction and acid phosphatase activity. In D. F. Gilbert, & O. Friedrich (Eds.), Cell Viability AssaysHumana Press (Springer). doi:10.1007/978-1-4939-6960-9_4

Mainstream adoption of physiologically-relevant three-dimensional models has been slow in the last 50 years due to long, manual protocols with poor reproducibility, high price and closed commercial platforms. This chapter describes high-throughput, l... Read More

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications (2016)
Journal Article
Taresco, V., Suksiriworapong, J., Styliari, I. D., Argent, R. H., Swainson, S. M., Booth, J., …Garnett, M. C. (in press). New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications. RSC Advances, 6(111), 109401-109405. doi:10.1039/C6RA21464A

A novel class of biodegradable polyesters has been generated by coupling poly(glycerol adipate) with N-acyl aromatic amino acids. This new set of polymers from this highly versatile polymeric platform may offer unprecedented new opportunities to prod... Read More

Penetration and intracellular uptake of poly(glycerol-adipate)nanoparticles into 3-dimensional brain tumour cell culture models (2016)
Journal Article
Meng, W., Garnett, M. C., Walker, D. A., & Parker, T. L. (2016). Penetration and intracellular uptake of poly(glycerol-adipate)nanoparticles into 3-dimensional brain tumour cell culture models. Experimental Biology and Medicine, 241(5), doi:10.1177/1535370215610441. ISSN 1535-3702

Nanoparticle (NP) drug delivery systems may potentially enhance the efficacy of therapeutic agents. It is difficult to characterise many important properties of NPs in vivo and therefore attempts have been made to use realistic in vitro multicellular... Read More

In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment (2015)
Journal Article
Ivanova, D. P., Parker, T. L., Walker, D. A., Alexander, C., Ashford, M. B., Gellert, P. R., & Garnett, M. C. (2015). In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment. Journal of Biotechnology, 205, 3-13. doi:10.1016/j.jbiotec.2015.01.002

Physiologically relevant in vitro models can serve as biological analytical platforms for testing novel treatments and drug delivery systems. We describe the first steps in the development of a 3D human brain tumour co-culture model that includes the... Read More

Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules (2014)
Journal Article
Stolnik-Trenkic, S., Vllasaliua, D., Falcone, F. H., & Garnett, M. (2014). Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules. Experimental Cell Research, 323(1), 218-231. doi:10.1016/j.yexcr.2014.02.022

This work examines the potential drug delivery barrier of the basement membrane (BM) by assessing the permeability of select macromolecules and nanoparticles. The study further extends to probing the effect of BM on intestinal epithelial cell attachm... Read More

Nanoparticle transport in epithelial cells: pathway switching through bioconjugation (2013)
Journal Article
Fowler, R., Vllasaliu, D., Trillo, F. F., Garnett, M., Alexander, C., Horsley, H., …Stolnik, S. (in press). Nanoparticle transport in epithelial cells: pathway switching through bioconjugation. Small, 9(19), doi:10.1002/smll.201202623. ISSN 1613-6810

The understanding and control of nanoparticle transport into and through cellular compartments is central to biomedical applications of nanotechnology. Here, it is shown that the transport pathway of 50 nm polystyrene nanoparticles decorated with vit... Read More