Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, Mengjie; Mountford, Simon J.; Richardson, Rachel R.; Groenen, Marleen; Holliday, Nicholas D.; Thompson, Philip E.

doi:10.1021/acs.jmedchem.6b00310

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Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach (2016)
Journal Article
Liu, M., Mountford, S. J., Richardson, R. R., Groenen, M., Holliday, N. D., & Thompson, P. E. (2016). Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach. Journal of Medicinal Chemistry, 59(13), 6059-6069. https://doi.org/10.1021/acs.jmedchem.6b00310

The dimeric peptide 1 (BVD-74D, as a diastereomeric mixture) is a potent and selective Neuropeptide Y Y4 receptor agonist. It represents a valuable candidate in developing traceable ligands for pharmacological studies of Y4 receptors, and as a lead c... Read More about Optically pure, structural and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach.