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An apicobasal gradient of Rac activity determines protrusion form and position (2017)
Journal Article
Couto, A., Mack, N. A., Favia, L., & Georgiou, M. (2017). An apicobasal gradient of Rac activity determines protrusion form and position. Nature Communications, 8, doi:10.1038/ncomms15385. ISSN 2041-1723

Each cell within a polarised epithelial sheet must align and correctly position a wide range of subcellular structures, including actin-based dynamic protrusions. Using in vivo inducible transgenes that can sense or modify Rac activity, we demonstrat... Read More

Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype (2015)
Conference Proceeding
Shohayeb, B., Georgiou, M., & Layfield, R. (2015). Contribution of Ref(2)p to regulation of Drosophila notum epithelial cell apico-basal polarity and phenotype

Cell polarity impacts on the maintenance of cell shape, cell-cell junction integrity, and protrusion formation and dynamics. Further, polarity additionally regulates cell movement, proliferation and differentiation. Conversely when cells lose their p... Read More