Research Repository

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Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial (2018)
Journal Article
Ford, G. A., Bhakta, B. B., Cozens, A., Hartley, S., Holloway, I., Meads, D., …Ford, G. A. (1156). Efficacy and safety of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo controlled trial. Manuscript submitted for publication

Background: Dopamine is a key modulator of striatal function and learning and may improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving motor recovery. M... Read More

The relationship between patients’ illness beliefs and recovery after stroke (2018)
Journal Article
Aujla, N., Walker, M., Vedhara, K., & Sprigg, N. (2019). The relationship between patients’ illness beliefs and recovery after stroke. Psychology, Health and Medicine, 24(5), 551-558. doi:10.1080/13548506.2018.1557712

The Common Sense Model (CSM) is a useful framework for understanding mood and treatment adherence amongst survivors in the acute phase of stroke. CSM stroke studies have thus far focused on the single outcomes, mood and medication adherence, neglecti... Read More

Bathing adaptations in the homes of older adults (BATH-OUT): results of a Feasibility Randomised Controlled Trial (RCT) (2018)
Journal Article
Whitehead, P. J., Golding-Day, M. R., Belshaw, S., Dawson, T., James, M., & Walker, M. F. (2018). Bathing adaptations in the homes of older adults (BATH-OUT): results of a Feasibility Randomised Controlled Trial (RCT). BMC Public Health, 18, 1-11. doi:10.1186/s12889-018-6200-4

Background: Housing adaptations have been identified as an important environmental and prevention intervention for older adults, which may improve health and quality of life. The onset of disability in bathing can act as a warning for further disabil... Read More

Family-led rehabilitation in India (ATTEND): findings from the process evaluation of a randomized controlled trial (2018)
Journal Article
Liu, H., Lindley, R., Alim, M., Felix, C., Gandhi, D. B., Verma, S. J., …Jan, S. (2019). Family-led rehabilitation in India (ATTEND): findings from the process evaluation of a randomized controlled trial. International Journal of Stroke, 14(1), 53-60. doi:10.1177/1747493018790076

Background: Training family carers to provide evidence-based rehabilitation to stroke patients could address the recognized deficiency of access to stroke rehabilitation in low-resource settings. However, our randomized controlled trial in India (ATT... Read More

Do individual versus illness belief schema differ in the prediction of post-stroke recovery? (2018)
Journal Article
Aujla, N., Walker, M. F., Sprigg, N., & Vedhara, K. (2018). Do individual versus illness belief schema differ in the prediction of post-stroke recovery?. Journal of Health Psychology, doi:10.1177/1359105318785446

This longitudinal observational study examined how individual versus illness belief schema compare as predictors of post-stroke recovery. Forty-two stroke survivors (mean age=66.9 years/range=29-96 years; 68% male), were involved. The primary outcome... Read More

Evaluating a stroke-specific version of the Illness Perception Questionnaire-Revised, using the Think-Aloud method (2018)
Journal Article
Aujla, N., Vedhara, K., Walker, M., & Sprigg, N. (in press). Evaluating a stroke-specific version of the Illness Perception Questionnaire-Revised, using the Think-Aloud method. Journal of Health Psychology, doi:10.1177/1359105318781942

The main purpose was to evaluate, using the Think-Aloud method, a version of the Illness Perception Questionnaire-Revised (IPQ-R) for stroke survivors (the Stroke IPQ-R). Six stroke survivors (mean age=58.8 years, range=31 to 78 years, SD=18.9 years)... Read More

Early, specialist vocational rehabilitation to facilitate return to work after traumatic brain injury: the FRESH feasibility RCT (2018)
Journal Article
Radford, K. A., Sutton, C., Sach, T., Holmes, J., Watkins, C. L., Forshaw, D., …Phillips, J. (2018). Early, specialist vocational rehabilitation to facilitate return to work after traumatic brain injury: the FRESH feasibility RCT. Health Technology Assessment, 22(33), doi:10.3310/hta22330

Background Up to 160,000 people incur traumatic brain injury (TBI) each year in the UK. TBI can have profound effects on many areas of human functioning, including participation in work. There is limited evidence of the clinical effectiveness and... Read More

Content and acceptability of an Occupational Therapy Intervention in Homecare Re-ablement Services (OTHERS) (2018)
Journal Article
Whitehead, P. J., Drummond, A. E., Parry, R. H., & Walker, M. F. (2018). Content and acceptability of an Occupational Therapy Intervention in Homecare Re-ablement Services (OTHERS). British Journal of Occupational Therapy, 81(9), 535-542. doi:10.1177/0308022618766844

Introduction: Despite clear compatibilities between the tenets of occupational therapy and re-ablement, there is limited research on occupational therapy in homecare reablement services. This paper describes the content of an occupational therapy int... Read More

Biopsychosocial Intervention for Stroke Carers (BISC): protocol for a feasibility randomized controlled trial (2017)
Journal Article
Walker, M. F., Thomas, S. A., Whitehead, P. J., Condon, L., Fisher, R. J., Kontou, E., …Cobley, C. (in press). Biopsychosocial Intervention for Stroke Carers (BISC): protocol for a feasibility randomized controlled trial. BMJ Open, 7, doi:10.1136/bmjopen-2017-018309

Introduction Reducing length of hospital stay for stroke survivors often creates a shift in the responsibility of care towards informal carers. Adjustment to the caregiving process is experienced by many carers as overwhelming, complex and demand... Read More

Interventions to reduce dependency in bathing in community dwelling older adults: a systematic review (2017)
Journal Article
Golding-Day, M., Whitehead, P., Radford, K., & Walker, M. (2017). Interventions to reduce dependency in bathing in community dwelling older adults: a systematic review. Systematic Reviews, 6(1), doi:10.1186/s13643-017-0586-4

Background The onset of bathing disability for older adults has been found to be an indicator and potential precursor of further disability. Thus interventions targeting bathing may prevent or delay further disability and the use of health and soc... Read More

Moving rehabilitation research forward: developing consensus statements for rehabilitation and recovery research (2017)
Journal Article
Bernhardt, J., Borschmann, K., Boyd, L., Carmichael, S. T., Corbett, D., Cramer, S. C., …Ward, N. (2017). Moving rehabilitation research forward: developing consensus statements for rehabilitation and recovery research. Neurorehabilitation and Neural Repair, 31(8), 694-658. doi:10.1177/1545968317724290

Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and... Read More

Improving the development, monitoring and reporting of stroke rehabilitation research: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable (SRRR) (2017)
Journal Article
Walker, M. F., Hoffmann, T. C., Brady, M. C., Dean, C. M., Eng, J. J., Farrin, A. J., …Watkins, C. L. (2017). Improving the development, monitoring and reporting of stroke rehabilitation research: consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable (SRRR). International Journal of Stroke, 12(5), doi:10.1177/1747493017711815

Recent reviews have demonstrated that the quality of stroke rehabilitation research has continued to improve over the last four decades but despite this progress there are still many barriers in moving the field forward. Rigorous development, monitor... Read More

Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial (2017)
Journal Article
Lindley, R., Anderson, C. S., Billot, L., Forster, A., Hackett, M. L., Harvey, L. A., …Pandian, J. D. (2017). Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial. Lancet, 390(10094), 588-599. doi:10.1016/S0140-6736(17)31447-2

Background: Most people with stroke in India have no access to organised rehabilitation services. The effectiveness of training family members to provide stroke rehabilitation is uncertain. Our primary objective was to determine whether family-led st... Read More

Bathing adaptations in the homes of older adults (BATH-OUT): protocol for a feasibility randomised controlled trial (RCT) (2016)
Journal Article
Whitehead, P. J., James, M., Belshaw, S., Dawson, T., Day, M. R., & Walker, M. F. (2016). Bathing adaptations in the homes of older adults (BATH-OUT): protocol for a feasibility randomised controlled trial (RCT). BMJ Open, 6(10), doi:10.1136/bmjopen-2016-013448

Introduction The Care Act 2014 has placed a responsibility on local authorities in England to provide services that prevent deterioration and minimise the use of other health and social care services. Housing adaptations have been identified as 1 of... Read More

Protocol for process evaluation of a randomised controlled trial of family-led rehabilitation post stroke (ATTEND) in India (2016)
Journal Article
Liu, H., Lindley, R., Alim, M., Felix, C., Gandhi, D. B., Verma, S. J., …Jan, S. (2016). Protocol for process evaluation of a randomised controlled trial of family-led rehabilitation post stroke (ATTEND) in India. BMJ, 6(e01202), doi:10.1136/bmjopen-2016-012027

Introduction We are undertaking a randomised controlled trial (fAmily led rehabiliTaTion aftEr stroke in INDia, ATTEND) evaluating training a family carer to enable maximal rehabilitation of patients with stroke-related disability; as a potentially a... Read More

Granulocyte colony stimulating factor and physiotherapy after stroke: results of a feasibility randomised controlled trial: stem cell trial of recovery enhancement after Stroke-3 (STEMS-3 ISRCTN16714730) (2016)
Journal Article
Sprigg, N., O’Connor, R., Woodhouse, L. J., Krishnan, K., England, T. J., Connell, L. A., …Bath, P. M. (2016). Granulocyte colony stimulating factor and physiotherapy after stroke: results of a feasibility randomised controlled trial: stem cell trial of recovery enhancement after Stroke-3 (STEMS-3 ISRCTN16714730). PLoS ONE, 11(9), doi:10.1371/journal.pone.0161359

Background Granulocyte-colony stimulating factor (G-CSF) mobilises endogenous haematopoietic stem cells and enhances recovery in experimental stroke. Recovery may also be dependent on an enriched environment and physical activity. G-CSF may have the... Read More

Occupational Therapy in HomEcare Re-ablement Services (OTHERS): results of a feasibility randomised controlled trial (2016)
Journal Article
Whitehead, P. J., Walker, M. F., Parry, R. H., Latif, Z., McGeorge, I. D., & Drummond, A. E. (2016). Occupational Therapy in HomEcare Re-ablement Services (OTHERS): results of a feasibility randomised controlled trial. BMJ Open, 6(8), doi:10.1136/bmjopen-2016-011868

Objectives: The objective of this study was to test the feasibility of conducting a randomised controlled trial (RCT) of an intervention targeted at activities of daily living (ADL), delivered by an occupational therapist, in homecare reablement.... Read More

Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB) (2016)
Journal Article
Clarke, C. E., Patel, S., Ives, N., Rick, C. E., Woolley, R., Wheatley, K., …Sackley, C. M. (2016). Clinical effectiveness and cost-effectiveness of physiotherapy and occupational therapy versus no therapy in mild to moderate Parkinson’s disease: a large pragmatic randomised controlled trial (PD REHAB). Health Technology Assessment, 20(63), doi:10.3310/hta20630

Background Cochrane reviews of physiotherapy (PT) and occupational therapy (OT) for Parkinson’s disease found insufficient evidence of effectiveness, but previous trials were methodologically flawed with small sample size and short-term follow-up.... Read More

Critique of home constraint-induced movement therapy trial: constraint-induced movement therapy study prompts the need for further research (2016)
Journal Article
constraint-induced movement therapy study prompts the need for further research. Stroke, 47(7), doi:10.1161/STROKEAHA.116.012423

Enhancing recovery from stroke with effective rehabilitation interventions remains an elusive goal.1 Although intensive rehabilitation therapies such as constraint-induced movement therapy (CIMT) show promise,2 the intervention has not been deployed... Read More