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All Outputs (102)

Evaluating the UK's first national prescribing assessment for GPs in training using an online survey (2023)
Journal Article
Knox, R., Bell, B., Salema, N., Emerson, K., Bodgener, S., Rial, J., …Avery, A. J. (2023). Evaluating the UK's first national prescribing assessment for GPs in training using an online survey. BJGP Open, 7(4), Article 044. https://doi.org/10.3399/BJGPO.2023.0044

Background GP trainees may not have experienced a systematic and comprehensive education in safe prescribing. Therefore, a self-assessment prescribing review was developed. Aim To determine whether the assessment was feasible, had face validity, a... Read More about Evaluating the UK's first national prescribing assessment for GPs in training using an online survey.

The impact of ageing on adults with cerebral palsy (2023)
Journal Article
Bell, B., Shah, S., Coulson, N., McLaughlin, J., Logan, P., Luke, R., & Avery, A. J. (2023). The impact of ageing on adults with cerebral palsy. British Journal of General Practice Open, 7(4), Article 0028. https://doi.org/10.3399/BJGPO.2023.0028

Background Cerebral palsy (CP) is one of the most common neurological disorders in children and results in lifelong physical impairments. Adults with CP have approximately the same life expectancy as their non-disabled peers, so helping them to stay... Read More about The impact of ageing on adults with cerebral palsy.

Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records (2023)
Journal Article
Joseph, R. M., Knaggs, R. D., Coupland, C. A., Taylor, A., Vinogradova, Y., Butler, D., …Jack, R. H. (2023). Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records. BMC Geriatrics, 23(1), Article 435. https://doi.org/10.1186/s12877-023-04143-2

Background Medication reviews in primary care provide an opportunity to review and discuss the safety and appropriateness of a person’s medicines. However, there is limited evidence about access to and the impact of routine medication reviews for old... Read More about Frequency and impact of medication reviews for people aged 65 years or above in UK primary care: an observational study using electronic health records.

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics (2023)
Journal Article
Fisher, L., Hopcroft, L. E., Rodgers, S., Barrett, J., Oliver, K., Avery, A. J., …MacKenna, B. (2023). Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics. BMJ Medicine, 2(1), Article e000392. https://doi.org/10.1136/bmjmed-2022-000392

Objective: To implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing. Design: Popula... Read More about Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using federated analytics.

Patient safety in prisons: a multi-method analysis of reported incidents in England (2023)
Journal Article
McFadzean, I. J., Davies, K., Purchase, T., Edwards, A., Hellard, S., Ashcroft, D. M., …Carson-Stevens, A. (2023). Patient safety in prisons: a multi-method analysis of reported incidents in England. Journal of the Royal Society of Medicine, 116(7), 236-245. https://doi.org/10.1177/01410768231166138

Objectives Prisoners use healthcare services three times more frequently than the general population with poorer health outcomes. Their distinct healthcare needs often pose challenges to safe healthcare provision. This study aimed to characterise pa... Read More about Patient safety in prisons: a multi-method analysis of reported incidents in England.

Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration (2023)
Journal Article
Cattell, M., Hyde, K., Bell, B., Dawson, T., Hills, T., Iyen, B., …Avery, A. (2023). Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration. European Journal of Hospital Pharmacy, https://doi.org/10.1136/ejhpharm-2022-003515

Objectives: To describe the frequency of the different types of medication-related incidents that caused patient harm, or adverse consequences, in a major teaching hospital and investigate whether the likelihood of these incidents occurring would hav... Read More about Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration.

Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration (2023)
Journal Article
Cattell, M., Hyde, K., Bell, B., Dawson, T., Hills, T., Iyen, B., …Avery, A. (in press). Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration. European Journal of Hospital Pharmacy, Article 003515. https://doi.org/10.1136/ejhpharm-2022-003515

Objectives To describe the frequency of the different types of medication-related incidents that caused patient harm, or adverse consequences, in a major teaching hospital and investigate whether the likelihood of these incidents occurring would hav... Read More about Retrospective review of medication-related incidents at a major teaching hospital and the potential mitigation of these incidents with electronic prescribing and medicines administration.

Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study (2022)
Journal Article
Rodgers, S., Taylor, A. C., Roberts, S. A., Allen, T., Ashcroft, D. M., Barrett, J., …Avery, A. J. (2022). Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study. PLoS Medicine, 19(11), Article e1004133. https://doi.org/10.1371/journal.pmed.1004133

Background: We previously reported on a randomised trial demonstrating the effectiveness and cost-effectiveness of a pharmacist-led information technology intervention (PINCER). We sought to investigate whether PINCER was effective in reducing hazard... Read More about Scaling-up a pharmacist-led information technology intervention (PINCER) to reduce hazardous prescribing in general practices: Multiple interrupted time series study.

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial (2022)
Journal Article
Hawkey, C., Avery, A., Coupland, C. A., Crooks, C., Dumbleton, J., Hobbs, F. D. R., …Hodgson, S. (2022). Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial. Lancet, 400(10363), 1597-1606. https://doi.org/10.1016/S0140-6736%2822%2901843-8

Background: Peptic ulcers in patients receiving aspirin are associated with Helicobacter pylori infection. We aimed to investigate whether H pylori eradication would protect against aspirin-associated ulcer bleeding. Methods: We conducted a randomise... Read More about Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial.

Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial (2022)
Journal Article
Mackenzie, I. S., Hawkey, C. J., Ford, I., Greenlaw, N., Pigazzani, F., Rogers, A., …MacDonald, T. M. (2022). Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400(10359), 1195-1205. https://doi.org/10.1016/S0140-6736%2822%2901657-9

Background: Allopurinol is a urate-lowering therapy used to treat patients with gout. Previous studies have shown that allopurinol has positive effects on several cardiovascular parameters. The ALL-HEART study aimed to determine whether allopurinol t... Read More about Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.

Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: A qualitative exploration using the Theoretical Framework of Acceptability (2022)
Journal Article
Laing, L., Salema, N., Jeffries, M., Shamsuddin, A., Sheikh, A., Chuter, A., …Keers, R. N. (2022). Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: A qualitative exploration using the Theoretical Framework of Acceptability. PLoS ONE, 17(10), Article e0275633. https://doi.org/10.1371/journal.pone.0275633

Introduction Medication errors are an important cause of morbidity and mortality. The pharmacist-led IT-based intervention to reduce clinically important medication errors (PINCER) intervention was shown to reduce medication errors when tested in a c... Read More about Understanding factors that could influence patient acceptability of the use of the PINCER intervention in primary care: A qualitative exploration using the Theoretical Framework of Acceptability.

Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme (2022)
Journal Article
Sheikh, A., Coleman, J., Chuter, A., Williams, R., Lilford, R., Slee, A., …Watson, N. (2022). Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme. Programme Grants for Applied Research, 10(7), 1-164. https://doi.org/10.3310/KSRS2009

Background: There is a need to identify approaches to reduce medication errors. Interest has converged on ePrescribing systems that incorporate computerised provider order entry and clinical decision support functionality. Objectives: We sought to de... Read More about Electronic prescribing systems in hospitals to improve medication safety: a multimethods research programme.

Understanding factors influencing uptake and sustainable use of the PINCER intervention at scale: A qualitative evaluation using Normalisation Process Theory (2022)
Journal Article
Laing, L., Salema, N. E., Jeffries, M., Shamsuddin, A., Sheikh, A., Chuter, A., …Keers, R. N. (2022). Understanding factors influencing uptake and sustainable use of the PINCER intervention at scale: A qualitative evaluation using Normalisation Process Theory. PLoS ONE, 17(9), Article e0274560. https://doi.org/10.1371/journal.pone.0274560

INTRODUCTION: Medication errors are an important cause of morbidity and mortality. The pharmacist-led IT-based intervention to reduce clinically important medication errors (PINCER) has demonstrated improvements in primary care medication safety, and... Read More about Understanding factors influencing uptake and sustainable use of the PINCER intervention at scale: A qualitative evaluation using Normalisation Process Theory.

The frequency and nature of prescribing problems by GPs-in-training (REVISiT): a retrospective review (2022)
Journal Article
Salema, N. E., Bell, B., Marsden, K., Gookey, G., Swanwick, G., Bassi, M., …Knox, R. (2022). The frequency and nature of prescribing problems by GPs-in-training (REVISiT): a retrospective review. BJGP Open, 6(3), Article BJGPO.2021.0231. https://doi.org/10.3399/BJGPO.2021.0231

Background: Prescribing errors can cause significant morbidity and occur in about 5% of prescriptions in English general practices. Aim: To describe the frequency and nature of prescribing problems in a cohort of GPs-in-training to determine whether... Read More about The frequency and nature of prescribing problems by GPs-in-training (REVISiT): a retrospective review.

Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout (2022)
Journal Article
Cipolletta, E., Tata, L. J., Nakafero, G., Avery, A. J., Mamas, M. A., & Abhishek, A. (2022). Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout. Journal of the American Medical Association, 328(5), 440-450. https://doi.org/10.1001/jama.2022.11390

Importance: Gout is associated with cardiovascular diseases. The temporal association between gout flares and cardiovascular events has not been investigated. Objective: To investigate whether there is a transient increase in risk of cardiovascular e... Read More about Association between Gout Flare and Subsequent Cardiovascular Events among Patients with Gout.

Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink (2022)
Journal Article
Abhishek, A., Cipolletta, E., Nakafero, G., Avery, A. J., Mamas, M., & Tata, L. J. (2022). Serum urate outcomes of treat-to-target urate lowering treatment: results of a nationwide cohort study from 1997 to the COVID-19 pandemic using data from the Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, 81(12), https://doi.org/10.1136/ard-2022-222668

Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT) (2022)
Journal Article
Stevenson, D. J., Avery, A. J., Coupland, C., Hobbs, F. D. R., Kendrick, D., Moore, M. V., …Dumbleton, J. S. (2022). Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT). Trials, 23(1), Article 140. https://doi.org/10.1186/s13063-022-06054-w

Background: The Helicobacter Eradication Aspirin Trial (HEAT) is a multicentre, double blind, randomised controlled trial investigating whether Helicobacter (H.) pylori eradication reduces hospitalisation for peptic ulcer bleeding. Recruited particip... Read More about Recruitment to a large scale randomised controlled clinical trial in primary care: the Helicobacter Eradication Aspirin Trial (HEAT).

Has the gout epidemic peaked in the UK? A nationwide cohort study using data from the Clinical Practice Research Datalink, from 1997 to across the COVID-19 pandemic in 2021 (2022)
Journal Article
Abhishek, A., Tata, L. J., Mamas, M., & Avery, A. J. (2022). Has the gout epidemic peaked in the UK? A nationwide cohort study using data from the Clinical Practice Research Datalink, from 1997 to across the COVID-19 pandemic in 2021. Annals of the Rheumatic Diseases, 81(6), 898-899. https://doi.org/10.1136/annrheumdis-2021-221989

Managing medicines at the end of life: a position paper for health policy and practice (2021)
Journal Article
Latif, A., Faull, C., Waring, J., Wilson, E., Anderson, C., Avery, A., & Pollock, K. (2021). Managing medicines at the end of life: a position paper for health policy and practice. Journal of Health Organization and Management, 35(9), 368-377. https://doi.org/10.1108/JHOM-11-2020-0440

Purpose: The impact of population ageing is significant, multifaceted and characterised by frailty and multi-morbidity. The COVID-19 pandemic has accelerated care pathways and policies promoting self-management and home-based care. One under-research... Read More about Managing medicines at the end of life: a position paper for health policy and practice.

Managing medicines at the end of life: a position paper for health policy and practice (2021)
Journal Article
Latif, A., Faull, C., Waring, J., Wilson, E., Anderson, C., Avery, A., & Pollock, K. (2021). Managing medicines at the end of life: a position paper for health policy and practice. Journal of Health Organization and Management, 35(9), 368-377. https://doi.org/10.1108/JHOM-11-2020-0440

Purpose The impact of population aging is significant, multifaceted and characterised by frailty and multi-morbidity. The COVID-19 pandemic has accelerated care pathways and policies promoting self-management and home-based care. One under-researched... Read More about Managing medicines at the end of life: a position paper for health policy and practice.