Skip to main content

Research Repository

See what's under the surface


Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2020)
Journal Article
Shannon, O. M., Mendes, I., Köchl, C., Mazidi, M., Ashor, A. W., Rubele, S., …Siervo, M. (2020). Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Journal of Nutrition, https://doi.org/10.1093/jn/nxaa002

Background The endothelium plays a key role in the maintenance of vascular health and represents a potential physiological target for dietary and other lifestyle interventions designed to reduce the risk of cardiovascular diseases (CVD) including... Read More about Mediterranean Diet Increases Endothelial Function in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Mediterranean diet adherence and cognitive function in older UK adults: the European Prospective Investigation into Cancer and Nutrition–Norfolk (EPIC-Norfolk) Study (2019)
Journal Article
Shannon, O. M., Stephan, B. C. M., Granic, A., Lentjes, M., Hayat, S., Mulligan, A., …Siervo, M. (2019). Mediterranean diet adherence and cognitive function in older UK adults: the European Prospective Investigation into Cancer and Nutrition–Norfolk (EPIC-Norfolk) Study. American Journal of Clinical Nutrition, 110(4), 938-948. https://doi.org/10.1093/ajcn/nqz114

Effects of inorganic nitrate and vitamin C co-supplementation on blood pressure and vascular function in younger and older healthy adults: A randomised double-blind crossover trial (2019)
Journal Article
Ashor, A. W., Shannon, O. M., Werner, A., Scialo, F., Gilliard, C. N., Cassel, K. S., …Siervo, M. (2019). Effects of inorganic nitrate and vitamin C co-supplementation on blood pressure and vascular function in younger and older healthy adults: A randomised double-blind crossover trial. Clinical Nutrition, https://doi.org/10.1016/j.clnu.2019.03.006

Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition (2017)
Journal Article
Siervo, M., Wandrag, L., Riley, H. L., Khosravi, M., Fernandez, B. O., Leckstrom, C. A., …Feelisch, M. (2017). Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition. Redox Biology, 13, 60-68. https://doi.org/10.1016/j.redox.2017.05.004

© 2017 Objectives Sarcopenia refers to the involuntary loss of skeletal muscle and is a predictor of physical disability/mortality. Its pathogenesis is poorly understood, although roles for altered hypoxic signaling, oxidative stress, adipokines and... Read More about Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition.

Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release (2016)
Journal Article
Roberts, L. D., Ashmore, T., McNally, B. D., Murfitt, S. A., Fernandez, B. O., Feelisch, M., …Griffin, J. L. (2017). Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release. Diabetes, 66(3), 674-688. https://doi.org/10.2337/db16-0843

© 2017 by the American Diabetes Association. Exercise is an effective intervention for the prevention and treatment of type 2 diabetes. Skeletal muscle combines multiple signals that contribute to the beneficial effects of exercise on cardiometabolic... Read More about Inorganic Nitrate Mimics Exercise-Stimulated Muscular Fiber-Type Switching and Myokine and γ-Aminobutyric Acid Release.

Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity (2016)
Journal Article
Babraj, J., Cuthbertson, D. J., Leese, G., & Siervo, M. (2017). Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity. Clinical Nutrition, 36(6), 1716-1719. https://doi.org/10.1016/j.clnu.2016.11.012

© 2016 Background Ageing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss. We investigated whether anabolic resistance to feeding might underlie accelerated muscle loss in older people with T2DM and whether dysregulated m... Read More about Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.

Inorganic nitrate supplementation in young and old obese adults does not affect acute glucose and insulin responses but lowers oxidative stress (2016)
Journal Article
Ashor, A. W., Chowdhury, S., Oggioni, C., Qadir, O., Brandt, K., Ishaq, A., …Siervo, M. (2016). Inorganic nitrate supplementation in young and old obese adults does not affect acute glucose and insulin responses but lowers oxidative stress. Journal of Nutrition, 146(11), 2224-2232. https://doi.org/10.3945/jn.116.237529

© 2016 American Society for Nutrition. Background: Aging and obesity are associated with raised oxidative stress and a reduction of nitric oxide (NO) bioavailability, with subsequent decline in insulin sensitivity and endothelial function. Inorganic... Read More about Inorganic nitrate supplementation in young and old obese adults does not affect acute glucose and insulin responses but lowers oxidative stress.

Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity (2015)
Journal Article
Bemis, T., Brychta, R., Chen, K., Courville, A., Crayner, E., Goodwin, S., …Hall, K. D. (2015). Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity. Cell Metabolism, 22(3), 427-436. https://doi.org/10.1016/j.cmet.2015.07.021

© 2015 Elsevier Inc. Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5-d... Read More about Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity.

Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure (2015)
Journal Article
Siervo, M., Faber, P., Lara, J., Gibney, E. R., Milne, E., Ritz, P., …Johnstone, A. M. (2015). Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure. Metabolism, 64(8), 896-904. https://doi.org/10.1016/j.metabol.2015.03.011

© 2015 Elsevier Inc. All rights reserved. Objectives. Weight loss (WL) is associated with a decrease in total and resting energy expenditure (EE). We aimed to investigate whether (1) diets with different rate and extent of WL determined different cha... Read More about Imposed rate and extent of weight loss in obese men and adaptive changes in resting and total energy expenditure.

Accuracy of prediction equations for serum osmolarity in frail older people with and without diabetes (2014)
Journal Article
Prado, C. M., Siervo, M., Bunn, D., Prado, C. M., & Hooper, L. (2014). Accuracy of prediction equations for serum osmolarity in frail older people with and without diabetes. American Journal of Clinical Nutrition, 100(3), 867-876. https://doi.org/10.3945/ajcn.114.086769

Background: Serum osmolality is an accurate indicator of hydration status in older adults. Glucose, urea, and electrolyte concentrations are used to calculate serum osmolarity, which is an indirect estimate of serum osmolality, but which serum osmola... Read More about Accuracy of prediction equations for serum osmolarity in frail older people with and without diabetes.