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All Outputs (13)

Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system (2023)
Journal Article
Daudre-Vignier, C., Bates, D. G., Scott, T. E., Hardman, J. G., & Laviola, M. (2023). Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system. Resuscitation, 186, Article 109758. https://doi.org/10.1016/j.resuscitation.2023.109758

Objective: We aimed to use a high-fidelity computational model that captures key interactions between the cardiovascular and pulmonary systems to investigate whether current CPR protocols could potentially be improved. Methods: We developed and valid... Read More about Evaluating current guidelines for cardiopulmonary resuscitation using an integrated computational model of the cardiopulmonary system.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article
Ellis, R., Laviola, M., Stolady, D., Valentine, R. L., Pillai, A., & Hardman, J. G. (2022). Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study. British Journal of Anaesthesia, 129(4), 581-587. https://doi.org/10.1016/j.bja.2022.06.021

Background Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study (2022)
Journal Article
Ellis, R., Laviola, M., Stolady, D., Valentine, R. L., Pillai, A., & Hardman, J. G. (2022). Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study. British Journal of Anaesthesia, 129(4), 581-587. https://doi.org/10.1016/j.bja.2022.06.021

Background: Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to... Read More about Comparison of apnoeic oxygen techniques in term pregnant subjects: a computational modelling study.

Ventilation strategies for front of neck airway rescue: an in silico study (2021)
Journal Article
Laviola, M., Niklas, C., Das, A., Bates, D. G., & Hardman, J. G. (2021). Ventilation strategies for front of neck airway rescue: an in silico study. British Journal of Anaesthesia, 126(6), 1226-1236. https://doi.org/10.1016/j.bja.2021.01.030

Background. During induction of general anaesthesia a “can’t intubate, can’t oxygenate” (CICO) situation can arise, leading to severe hypoxaemia. Evidence is scarce to guide ventilation strategies for small-bore front of neck airways that ensure effe... Read More about Ventilation strategies for front of neck airway rescue: an in silico study.

Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation (2021)
Journal Article
Stolady, D., Laviola, M., Pillai, A., & Hardman, J. G. (2021). Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation. British Journal of Anaesthesia, 126(4), 889-895. https://doi.org/10.1016/j.bja.2020.12.031

Background Studies of pulmonary denitrogenation (pre-oxygenation) in obstetric populations have shown high flow nasal oxygen therapy (HFNO) is inferior to facemask techniques. HFNO achieves median end-tidal oxygen fraction (FE′O2) of 0.87 after 3... Read More about Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation.

In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications (2020)
Journal Article
Das, A., Saffaran, S., Chikhani, M., Scott, T. E., Laviola, M., Yehya, N., …Bates, D. G. (2020). In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications. Critical Care Explorations, 2(9), Article e0202. https://doi.org/10.1097/CCE.0000000000000202

Objectives: Patients with COVID-19 Acute Respiratory Distress Syndrome (CARDS) appear to present with at least two distinct phenotypes: severe hypoxemia with relatively well-preserved lung compliance and lung gas volumes (Type 1) and a more conventio... Read More about In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications.

Effect of oxygen fraction on airway rescue: a computational modelling study (2020)
Journal Article
Laviola, M., Niklas, C., Das, A., Bates, D. G., & Hardman, J. G. (2020). Effect of oxygen fraction on airway rescue: a computational modelling study. British Journal of Anaesthesia, 125(1), e69-e74. https://doi.org/10.1016/j.bja.2020.01.004

© 2020 British Journal of Anaesthesia Background: During induction of general anaesthesia, patients frequently experience apnoea, which can lead to dangerous hypoxaemia. An obstructed upper airway can impede attempts to provide ventilation. Although... Read More about Effect of oxygen fraction on airway rescue: a computational modelling study.

Mathematical and Computational Modelling in Critical Illness (2019)
Journal Article
Laviola, M., Bates, D. G., & Hardman, J. G. (2019). Mathematical and Computational Modelling in Critical Illness. European Respiratory & Pulmonary Diseases, 5(1),

Mathematical and computational modelling are assuming a prominent role in investigating the complex pathophysiological states and therapeutic strategies in critical illness. This editorial briefly illustrates the models of the respiratory and cardiov... Read More about Mathematical and Computational Modelling in Critical Illness.

High oxygen fraction during airway opening is key to effective airway rescue in obese subjects (2019)
Conference Proceeding
Laviola, M., Christian, N., Alahmadi, H., Das, A., Bates, D. G., & Hardman, J. G. (2019). High oxygen fraction during airway opening is key to effective airway rescue in obese subjects. In 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (2357-2360). https://doi.org/10.1109/EMBC.2019.8857109

Apnea is common after induction of anesthesia and may produce dangerous hypoxemia, particularly in obese subjects. Optimal management of airway emergencies in obese, apneic subjects is complex and controversial, and clinical studies of rescue strateg... Read More about High oxygen fraction during airway opening is key to effective airway rescue in obese subjects.

Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea (2018)
Journal Article
Laviola, M., Das, A., Chikhani, M., Bates, D., & Hardman, J. (2019). Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea. British Journal of Anaesthesia, 122(3), 395-401. https://doi.org/10.1016/j.bja.2018.11.012

Background Apnoeic oxygenation can come close to matching the oxygen demands of the apnoeic patient but does not facilitate carbon dioxide (CO2) elimination, potentially resulting in dangerous hypercapnia. Numerous studies have shown that high-flo... Read More about Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea.

Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients (2018)
Journal Article
Laviola, M., Priori, R., D’Angelo, M. G., & Aliverti, A. (2018). Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients. PLoS ONE, 13(7), 1-13. https://doi.org/10.1371/journal.pone.0200582

Introduction In Duchenne muscular dystrophy (DMD) the assessment of diaphragmatic function is crucial because respiratory muscle weakness can cause respiratory failure. We aimed to noninvasively assess diaphragmatic function in DMD by measuring diap... Read More about Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients.

Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation (2017)
Conference Proceeding
Laviola, M., Das, A., Bates, D. G., & Hardman, J. G. (2017). Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation. In 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (337-340). https://doi.org/10.1109/EMBC.2017.8036831

Gaseous mixing in the anatomical deadspace with stimulation of respiratory ventilation through cardiogenic oscillations is an important physiological mechanism at the onset of apnea, which has been credited with various beneficial effects, e.g. reduc... Read More about Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation.