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Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis (2017)
Journal Article
Manouchehrinia, A., Tanasescu, R., Kareem, H., Jerca, O. P., Jabeen, F., Shafei, R., …Constantinescu, C. S. (in press). Prevalence of a history of prior varicella/herpes zoster infection in multiple sclerosis. Journal of NeuroVirology, doi:10.1007/s13365-017-0569-1. ISSN 1538-2443

Varicella zoster virus (VZV) infection has been implicated in multiple sclerosis (MS), but direct causal involvement has been disputed. Nevertheless, knowledge of VZV exposure is important, given the risk of serious complications of first exposure wh... Read More

Quantification of seed–soil contact of sugar beet (Beta vulgaris) using X-ray Computed Tomography (2017)
Journal Article
Blunk, S., Malik, A. H., de Heer, M. I., Ekblad, T., Bussell, J. S., Sparkes, D. L., …Mooney, S. J. (in press). Quantification of seed–soil contact of sugar beet (Beta vulgaris) using X-ray Computed Tomography. Plant Methods, 13(71), doi:10.1186/s13007-017-0220-4. ISSN 1746-4811

Abstract Background: Seed–soil contact is important to ensure successful germination, however, there is a paucity of reported studies that have quantified the microstructure at and around this critical interface, mainly due to the opacity of soil.... Read More

Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study (2017)
Journal Article
Tanasescu, R., Constantinescu, C. S., Tench, C. R., & Manouchehrinia, A. (2018). Smoking cessation and the reduction of disability progression in Multiple Sclerosis: a cohort study. Nicotine and Tobacco Research, 20(5), doi:10.1093/ntr/ntx084. ISSN 1462-2203

Background: Smoking is associated with a more severe disease course in people with multiple sclerosis (MS). The magnitude of effect of smoking cessation on MS progression is unknown. The aim of this study was to quantify the impact of smoking cessati... Read More

Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes (2014)
Journal Article
Hdud, I. M., Mobasheri, A., & Loughna, P. (2014). Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes. SpringerPlus, 3, doi:10.1186/2193-1801-3-59. ISSN 2193-1801

Background Chondrocytes are regularly exposed to load-induced stimuli and have the capability to sense and respond to applied mechanical stress. However, the mechanisms involved in chondrocyte mechanotransduction are not clearly understood. The pu... Read More

Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology (2013)
Journal Article
Swan, A. L., Mobasheri, A., Allaway, D., Liddell, S., & Bacardit, J. (2013). Application of machine learning to proteomics data: classification and biomarker identification in postgenomics biology. OMICS, 17(12), doi:10.1089/omi.2013.0017. ISSN 1536-2310

Mass spectrometry is an analytical technique for the characterization of biological samples and is increasingly used in omics studies because of its targeted, nontargeted, and high throughput abilities. However, due to the large datasets generated, i... Read More

Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration (2013)
Journal Article
Gould, T. W., Birchall, J. P., Mallick, A. S., Alliston, T., Lustig, L. R., Shakesheff, K. M., & Rahman, C. V. (2013). Development of a porous poly(DL-lactic acid-co-glycolic acid)-based scaffold for mastoid air-cell regeneration. Laryngoscope, 123(12), doi:10.1002/lary.24173. ISSN 0023-852X

Objectives/Hypothesis: To develop a porous, biodegradable scaffold for mastoid air-cell regeneration. Study Design: In vitro development of a temperature-sensitive poly(DL-lactic acid-co-glycolic acid)/poly(ethylene glycol) (PLGA/PEG) scaffold tailo... Read More

Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data? (2013)
Journal Article
Lewis, R., May, H., Mobasheri, A., & Barrett-Jolley, R. (2013). Chondrocyte channel transcriptomics: do microarray data fit with expression and functional data?. Channels, 7(6), doi:10.4161/chan.26071. ISSN 1933-6950

To date, a range of ion channels have been identified in chondrocytes using a number of different techniques, predominantly electrophysiological and/or biomolecular; each of these has its advantages and disadvantages. Here we aim to compare and contr... Read More

Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study (2013)
Journal Article
Manouchehrinia, A., Tench, C. R., Maxted, J., Bibani, R. H., Britton, J., & Constantinescu, C. S. (2013). Tobacco smoking and disability progression in multiple sclerosis: United Kingdom cohort study. Brain, 136(7), doi:10.1093/brain/awt139. ISSN 0006-8950

Tobacco smoking has been linked to an increased risk of multiple sclerosis. However, to date, results from the few studies on the impact of smoking on the progression of disability are conflicting. The aim of this study was to investigate the effects... Read More

Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes (2013)
Journal Article
Lewis, R., Feetham, C., Gentles, L., Penny, J., Tregilgas, L., Tohami, W., …Barrett-Jolley, R. (2013). Benzamil sensitive ion channels contribute to volume regulation in canine chondrocytes. British Journal of Pharmacology, 168(7), doi:10.1111/j.1476-5381.2012.02185.x. ISSN 0007-1188

Background and Purpose: Chondrocytes exist within cartilage and serve to maintain the extracellular matrix. It has been postulated that osteoarthritic (OA) chondrocytes lose the ability to regulate their volume, affecting extracellular matrix product... Read More