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Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome (2017)
Journal Article
Das, A., Haque, M., Chikhani, M., Cole, O., Wang, W., Hardman, J. G., & Bates, D. G. (2017). Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome. BMC Pulmonary Medicine, 17(34), doi:10.1186/s12890-017-0369-7. ISSN 1471-2466

Background: Clinical trials have, so far, failed to establish clear beneficial outcomes of recruitment maneuvers (RMs) on patient mortality in acute respiratory distress syndrome (ARDS), and the effects of RMs on the cardiovascular system remain poor... Read More

Modelling primary blast lung injury: current capability and future direction (2016)
Journal Article
Scott, T., Hulse, E., Haque, M., Kirkman, E., Hardman, J., & Mahoney, P. (in press). Modelling primary blast lung injury: current capability and future direction. Journal of the Royal Army Medical Corps, doi:10.1136/jramc-2016-000678. ISSN 2052-0468

Primary blast lung injury frequently complicates military conflict and terrorist attacks on civilian populations. The fact that it occurs in areas of conflict or unpredictable mass casualty events makes clinical study in human casualties implausible.... Read More

High PEEP in ARDS: quantitative evaluation between improved oxygenation and decreased oxygen delivery (2016)
Journal Article
Chikhani, M., Das, A., Haque, M., Wang, W., Bates, D., & Hardman, J. (2016). High PEEP in ARDS: quantitative evaluation between improved oxygenation and decreased oxygen delivery. British Journal of Anaesthesia, 117(5), doi:10.1093/bja/aew314. ISSN 0007-0912

Background: Positive end-expiratory pressure (PEEP) is widely used to improve oxygenation and prevent alveolar collapse in mechanically ventilated patients with the acute respiratory distress syndrome (ARDS). While PEEP predictably improves arterial... Read More

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation (2015)
Journal Article
Das, A., Cole, O., Chikhani, M., Wang, W., Ali, T., Haque, M., …Hardman, J. G. (2015). Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation. Critical Care, 19, doi:10.1186/s13054-014-0723-6

Introduction: Direct comparison of the relative efficacy of different recruitment maneuvers (RMs) for patients with acute respiratory distress syndrome (ARDS) via clinical trials is difficult, due to the heterogeneity of patient populations and disea... Read More

Transgenic nematodes as biosensors for metal stress in soil pore water samples (2012)
Journal Article
Anbalagan, C., Lafayette, I., Antoniou-Kourounioti, M., Haque, M., King, J., Johnsen, B., …de Pomerai, D. (2012). Transgenic nematodes as biosensors for metal stress in soil pore water samples. Ecotoxicology, 21(2), doi:10.1007/s10646-011-0804-0. ISSN 0963-9292

Caenorhabditis elegans strains carrying stress-reporter green fluorescent protein transgenes were used to explore patterns of response to metals. Multiple stress pathways were induced at high doses by most metals tested, including members of the heat... Read More