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All Outputs (85)

Biomarkers of kidney failure and all-cause mortality in chronic kidney disease (2025)
Journal Article
Onoja, A., McDonnell, T., Annessi, I., Banks, R. E., Bergin, M., Cockwell, P., Dusaulcy, R., Fraser, S. D., Johnson, T., Kalra, P. A., Lemaître, B., Saleem, M., Skroblin, P., Soderberg, M., Taal, M. W., Unwin, R. J., Vuilleumier, N., Wheeler, D. C., & Geifman, N. (2025). Biomarkers of kidney failure and all-cause mortality in chronic kidney disease. Journal of the American Society of Nephrology, https://doi.org/10.1681/ASN.0000000767

Background:
Chronic kidney disease (CKD) carries a variable risk for multiple adverse outcomes, highlighting the need for a personalised approach. This study evaluated several novel biomarkers linked to key disease mechanisms to predict the risk of... Read More about Biomarkers of kidney failure and all-cause mortality in chronic kidney disease.

Effect of haemodialysis on the brain and heart assessed using multiparametric MRI (2025)
Journal Article
Cox, E. F., Gullapudi, V. R. L., Buchanan, C. E., White, K., Nicholas, R., Canaud, B., Taal, M. W., Selby, N. M., & Francis, S. T. (in press). Effect of haemodialysis on the brain and heart assessed using multiparametric MRI. Nephrology Dialysis Transplantation,

Background and hypothesis
Haemodialysis (HD) patients often develop cognitive impairment, negatively impacting health-related quality of life. We use brain magnetic resonance imaging (MRI) measures to study the acute changes in cerebral water conte... Read More about Effect of haemodialysis on the brain and heart assessed using multiparametric MRI.

Kidney protective effects of glucagon-like peptide-1 receptor agonists versus sodium glucose cotransporter-2 inhibitors in persons with diabetes and CKD: implications for personalized medicine (2025)
Journal Article
Taal, M. W., Eldehni, M. T., Selby, N. M., & Taal, M. W. (in press). Kidney protective effects of glucagon-like peptide-1 receptor agonists versus sodium glucose cotransporter-2 inhibitors in persons with diabetes and CKD: implications for personalized medicine. American Journal of Kidney Diseases,

Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis (2025)
Journal Article
Lee, K. G. R., Ghadge, A., Raut, B., Veighey, K., Amin, J., Capasso, G., Cockwell, P., Kalra, P. A., Pepin, M., Phillips, T., Taal, M., Unwin, R., & Fraser, S. D. S. (2025). Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis. Clinical Kidney Journal, 18(6), Article sfaf150. https://doi.org/10.1093/ckj/sfaf150

Background
Cognitive impairment is prevalent in individuals with chronic kidney disease (CKD), but its effects on health outcomes remain unclear. While cognitive impairment can affect self-management, its role in CKD has been insufficiently explored... Read More about Cognitive impairment and health outcomes in non-dialysis chronic kidney disease: a systematic review and meta-analysis.

A novel system to continuously estimate intradialytic blood pressure in real time (2025)
Journal Article
Viramontes-Hörner, D., Stewart, P., Stewart, J., Taal, M. W., & Selby, N. M. (2025). A novel system to continuously estimate intradialytic blood pressure in real time. Nephrology Dialysis Transplantation, https://doi.org/10.1093/ndt/gfaf058

Background
Intradialytic hypotension (IDH) is a common complication of haemodialysis that is associated with adverse patient outcomes. We have developed a new non-invasive approach to continuously estimate systolic blood pressure (SBP) in real time... Read More about A novel system to continuously estimate intradialytic blood pressure in real time.

Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data (2025)
Journal Article
Kolhe, N. V., Fluck, R., & Taal, M. (2025). Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data. BMJ Open, 15(3), Article e095020. https://doi.org/10.1136/bmjopen-2024-095020

Objectives To evaluate hospital outcomes and their predictors during the pandemic for patients with and without COVID-19, stratified by the presence of acute kidney injury (AKI). Design Retrospective observation study using the Hospital Episodes Stat... Read More about Effect of COVID-19 with or without acute kidney injury on inpatient mortality in England: a national observational study using administrative data.

Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomised controlled trial (2025)
Journal Article
Briggs, J., Ralston, E., Wilkinson, T. J., Walklin, C., Mangahis, E., ML Young, H., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bramham10, K., Burton, J. O., Campbell, J., Chilcot, J., Deelchand, V., Hamilton, A., Jesky, M., Kalra, P. A., McCafferty, K., Nixon, A. C., …Greenwood, S. A. (2025). Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomised controlled trial. Clinical Kidney Journal, 18(3), Article sfaf041. https://doi.org/10.1093/ckj/sfaf041

Background
In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQo... Read More about Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomised controlled trial.

Personalized Care in CKD: Moving Beyond Traditional Biomarkers (2025)
Journal Article
McDonnell, T., Banks, R. E., Taal, M. W., Vuilleumier, N., & Kalra, P. A. (2025). Personalized Care in CKD: Moving Beyond Traditional Biomarkers. Nephron, 149(6), 339-357. https://doi.org/10.1159/000543640

Background: Traditional biomarkers, such as estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (uACR), have long been central to chronic kidney disease (CKD) diagnosis and management, leading to a standardized CKD class... Read More about Personalized Care in CKD: Moving Beyond Traditional Biomarkers.

The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study (2024)
Journal Article
McDonnell, T., Kalra, P. A., Vuilleumier, N., Cockwell, P., Wheeler, D. C., Fraser, S. D., Banks, R. E., & Taal, M. W. (2025). The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study. American Journal of Nephrology, 56(1), 1-12. https://doi.org/10.1159/000541770

Introduction: The definition of CKD is broad, which neglects the heterogeneity of risk across primary renal diseases.

Methods: The National Unified Renal Translational Research Enterprise (NURTuRE)-CKD is an ongoing UK, prospective multicenter coh... Read More about The Impact of Primary Renal Diagnosis on Prognosis and the Varying Predictive Power of Albuminuria in the NURTuRE-CKD Study.

Kidney Beam - a cost-effective digital intervention to improve mental health (2024)
Journal Article
Greenwood, S. A., Briggs, J., Walklin, C., Mangahis, E., Young, H. M., Castle, E. M., Billany, R. E., Asgari, E., Bhandari, S., Bishop, N., Bramham, K., Burton, J. O., Campbell, J., Chilcot, J., Cooper, N., Deelchand, V., Graham-Brown, M. P., Haggis, L., Hamilton, A., Jesky, M., …Macdonald, J. (2024). Kidney Beam - a cost-effective digital intervention to improve mental health. Kidney International Reports, 9(11), 3204-3217. https://doi.org/10.1016/j.ekir.2024.08.030

Introduction: There is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health... Read More about Kidney Beam - a cost-effective digital intervention to improve mental health.

Optimizing kidney and cardiovascular protection in an era of multiple effective treatments (2024)
Journal Article
Taal, M. W. (2024). Optimizing kidney and cardiovascular protection in an era of multiple effective treatments. Current Opinion in Nephrology and Hypertension, 33(6), 551-556. https://doi.org/10.1097/MNH.0000000000001019

Purpose of review After decades of relying on the control of hypertension and treatment with renin angiotensin system inhibitors as the only evidence-based interventions to slow the progression of chronic kidney disease (CKD), we have entered an era... Read More about Optimizing kidney and cardiovascular protection in an era of multiple effective treatments.

Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study. (2024)
Journal Article
Lamb, E. J., Barratt, J., Brettell, E. A., Cockwell, P., Dalton, R. N., Deeks, J. J., Eaglestone, G., Pellatt-Higgins, T., Kalra, P. A., Khunti, K., Loud, F. C., Ottridge, R. S., Potter, A., Rowe, C., Scandrett, K., Sitch, A. J., Stevens, P. E., Sharpe, C. C., Shinkins, B., Smith, A., …Taal, M. W. (2024). Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study. Health Technology Assessment, 28(35), 1-169. https://doi.org/10.3310/HYHN1078

Background: Estimation of glomerular filtration rate using equations based on creatinine is widely used to manage chronic kidney disease. In the UK, the Chronic Kidney Disease Epidemiology Collaboration creatinine equation is recommended. Other publi... Read More about Accuracy of glomerular filtration rate estimation using creatinine and cystatin C for identifying and monitoring moderate chronic kidney disease: the eGFR-C study..

National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study (2024)
Journal Article
Colby, E., Hayward, S., Benavente, M., Robertson, F., Bierzynska, A., Osborne, A., Parmesar, K., Afzal, M., Chapman, T., Ullah, F., Davies, E., Nation, M., Cook, W., Johnson, T., Andag, U., Radresa, O., Skroblin, P., Bayerlova, M., Unwin, R., Vuilleumier, N., …Saleem, M. A. (2024). National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study. Clinical Kidney Journal, 17(8), Article sfae096. https://doi.org/10.1093/ckj/sfae096

Background
Idiopathic Nephrotic Syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS coho... Read More about National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study.

Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis (2024)
Journal Article
Viramontes-Hörner, D., Selby, N. M., & Taal, M. W. (2024). Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis. Kidney International Reports, 9(7), 2110-2116. https://doi.org/10.1016/j.ekir.2024.03.020

Introduction: Elevated skin autofluorescence (SAF), a measure of tissue accumulation of advanced glycation end products (AGEs), is a strong predictor of all-cause and cardiovascular mortality in the hemodialysis population. However, prospective studi... Read More about Prospective study of change in skin autofluorescence over time and mortality in people receiving hemodialysis.

Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data (2024)
Journal Article
Kolhe, N. V., Fluck, R. J., & Taal, M. W. (in press). Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data. BMC Infectious Diseases, 24(1), Article 346. https://doi.org/10.1186/s12879-024-09210-6

Background: This study explores regional variations in COVID-19 hospitalization rates, in-hospital mortality, and acute kidney injury (AKI) in England. We investigated the influence of population demographic characteristics, viral strain changes, and... Read More about Regional variation of COVID-19 admissions, acute kidney injury and mortality in England - a national observational study using administrative data.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., Fox, C. P., Mallen, C. D., Maxwell, J. R., Bingham, S., Vedhara, K., & Abhishek, A. (2025). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, 64(3), 969-975. https://doi.org/10.1093/rheumatology/keae175

Objective
To explore the acceptability of an individualized risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s).

Methods
Ad... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease (2024)
Journal Article
Osborne, A. J., Bierzynska, A., Colby, E., Andag, U., Kalra, P. A., Radresa, O., Skroblin, P., Taal, M. W., Welsh, G. I., Saleem, M. A., & Campbell, C. (2024). Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease. npj Systems Biology and Applications, 10(1), Article 28. https://doi.org/10.1038/s41540-024-00350-8

Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with estimated glomerular filtration rate (eGFR) and blo... Read More about Multivariate canonical correlation analysis identifies additional genetic variants for chronic kidney disease.