Research Repository

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Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells (2018)
Journal Article
Alkhattabi, N., Todd, I., Negm, O., Tighe, P. J., & Fairclough, L. C. (2018). Tobacco smoke and nicotine suppress expression of activating signaling molecules in human dendritic cells. Toxicology Letters, 299, (40-46). doi:10.1016/j.toxlet.2018.09.002. ISSN 0378-4274

Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is that it inhibits the T cell-stimulating, immunogenic properties of myeloi... Read More

Highly sensitive label-free antibody detection using a long period fibre grating sensor (2018)
Journal Article
Liu, L., Marques, L., Correia, R., Morgan, S. P., Lee, S., Tighe, P. J., …Korposh, S. (2018). Highly sensitive label-free antibody detection using a long period fibre grating sensor. Sensors and Actuators B: Chemical, 271, doi:10.1016/j.snb.2018.05.109. ISSN 0925-4005

An optical fibre long period grating (LPG) biosensor is appealing in the detection of biomolecules because of the high sensitivity, label-free and real-time measurement. The miniaturized size, ability of remote sensing and immunity to electromagnetic... Read More

Measuring vaccine responses in the multiplex era (2018)
Book Chapter
Ayling, K., Vedhara, K., & Fairclough, L. (2018). Measuring vaccine responses in the multiplex era. In Q. Yan (Ed.), Psychoneuroimmunology: Methods and Protocols, 327-340. (2nd). Springer Publishing Company. doi:10.1007/978-1-4939-7828-1_17

Vaccine studies in psychoneuroimmunology (PNI) provide an insight into biopsychosocial interactions and their role in infectious diseases. How to measure vaccine responses is therefore of critical importance for PNI researchers. In this chapter, trad... Read More

Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics (2018)
Journal Article
Huckle, A. W., Fairclough, L. C., & Todd, I. (2018). Prophylactic antibiotic use in COPD and the potential anti-inflammatory activities of antibiotics. Current Respiratory Care Reports, 63(5), doi:10.4187/respcare.05943. ISSN 0020-1324

Antibiotics have previously demonstrated anti-inflammatory properties, and they have been linked to therapeutic benefit in several pulmonary conditions that feature inflammation. Previous research suggests that these anti-inflammatory properties may... Read More

Characterization of behavioral, signaling and cytokine alterations in a rat neurodevelopmental model for schizophrenia, and their reversal by the 5-HT₆ receptor antagonist SB-399885 (2018)
Journal Article
antagonist SB-399885. Molecular Neurobiology, doi:10.1007/s12035-018-0940-0. ISSN 0893-7648

Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT₆ receptor antagonist SB-399885 to reverse isolation-i... Read More

Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction (2016)
Journal Article
Tubby, C., Negm, O. H., Harrison, T. W., Tighe, P. J., Todd, I., & Fairclough, L. C. (in press). Peripheral killer cells do not differentiate between asthma patients with or without fixed airway obstruction. Journal of Asthma, doi:10.1080/02770903.2016.1236941. ISSN 0277-0903

Objective: The three main types of killer cells – CD8+ T cells, NK cells and NKT cells – have been linked to asthma and chronic obstructive pulmonary disease (COPD). However, their role in a small subset of asthma patients displaying fixed airway obs... Read More

The application of protein microarray assays in psychoneuroimmunology (2016)
Journal Article
Ayling, K., Bowden, T., Tighe, P. J., Todd, I., Dilnot, E. M., Hegm, O., …Vedhara, K. (2017). The application of protein microarray assays in psychoneuroimmunology. Brain, Behavior, and Immunity, 59, doi:10.1016/j.bbi.2016.09.013. ISSN 1090-2139

Protein microarrays are miniaturized multiplex assays that exhibit many advantages over the commonly used enzyme-linked immunosorbent assay (ELISA). This article aims to introduce protein microarrays to readers of Brain, Behavior, and Immunity and de... Read More

Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease (2016)
Journal Article
Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple circulating cytokines are coelevated in chronic obstructive pulmonary disease. Mediators of Inflammation, 2016, doi:10.1155/2016/3604842. ISSN 0962-9351

Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multipl... Read More

ELISA in the multiplex era: potentials and pitfalls (2015)
Journal Article
Tighe, P. J., Ryder, R. R., Todd, I., & Fairclough, L. C. (2015). ELISA in the multiplex era: potentials and pitfalls. PROTEOMICS - Clinical Applications, 9(3-4), doi:10.1002/prca.201400130. ISSN 1862-8346

Multiplex immunoassays confer several advantages over widely adopted singleplex immunoassays including increased efficiency at a reduced expense, greater output per sample volume ratios and higher throughput predicating more resolute, detailed diagno... Read More

Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease (2014)
Journal Article
Daffa, N., Tighe, P. J., Corne, J., Fairclough, L. C., & Todd, I. (2014). Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease. Clinical and Experimental Immunology, 180(1), doi:10.1111/cei.12565. ISSN 0009-9104

Autoimmunity may contribute to the pathogenesis of chronic obstructive pulmonary disease (COPD). Studies have identified disease-specific autoantibodies (DSAAbs) in COPD patients, but natural autoantibodies (NAAbs) may also play a role. Previous stud... Read More