Research Repository

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Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations (2018)
Journal Article
McKeever, T., Mortimer, K., Wilson, A., Walker, S., Brightling, C., Skeggs, A., …Harrison, T. (2018). Quadrupling inhaled glucocorticoid dose to abort asthma exacerbations. New England Journal of Medicine, 378(10), doi:10.1056/NEJMoa1714257. ISSN 0028-4793

BACKGROUND Asthma exacerbations are frightening for patients and are occasionally fatal. We tested the concept that a plan for patients to manage their asthma (self-management plan), which included a temporary quadrupling of the dose of inhaled gluc... Read More

The clinical and cost-effectiveness of rehabilitation of memory in brain injury: the ReMemBrIn RCT (2017)
Journal Article
das Nair, R., Bradshaw, L. E., Carpenter, H., Clarke, S., Day, F., Drummond, A., …Lincoln, N. B. (in press). The clinical and cost-effectiveness of rehabilitation of memory in brain injury: the ReMemBrIn RCT. Health Technology Assessment,

Background People with traumatic brain injuries (TBIs) commonly report memory impairments. These are persistent, debilitating, and reduce quality of life, but patients do not routinely receive memory rehabilitation after discharge from hospital. Ob... Read More

Randomised trial of cord clamping and initial stabilisation at very preterm birth (2017)
Journal Article
Duley, L., Dorling, J., Pushpa-Rajah, A., Oddie, S. J., William Yoxall, C., Schoonakker, B., …Fawke, J. A. (2017). Randomised trial of cord clamping and initial stabilisation at very preterm birth. Archives of Disease in Childhood. Fetal and Neonatal Edition, 103(1), F6-F14. doi:10.1136/archdischild-2016-312567

Objectives: For very preterm births, to compare alternative policies for umbilical cord clamping and immediate neonatal care. Design: Parallel group randomised (1:1) trial, using sealed opaque numbered envelopes. Setting: Eight UK tertiary mate... Read More

Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks (2017)
Journal Article
Langan, S. M., Stuart, B., Bradshaw, L., Schmitt, J., Williams, H. C., & Thomas, K. S. (2017). Measuring long‐term disease control in atopic dermatitis: a validation study of well controlled weeks. Journal of Allergy and Clinical Immunology, 140(6), doi:10.1016/j.jaci.2017.02.043. ISSN 0091-6749

Background:Because atopic dermatitis (AD) is a relapsing, remitting disease, assessing long‐term control is important. Well controlled weeks (WCWs) have been used to assess asthma long‐term control, but never validated for AD. Objectives: To assess... Read More

Labour induction near term for women aged 35 or over: an economic evaluation (2017)
Journal Article
Walker, K. F., Dritsaki, M., Bugg, G., Macpherson, M., McCormick, C., Grace, N., …Thornton, J. (2017). Labour induction near term for women aged 35 or over: an economic evaluation. BJOG: An International Journal of Obstetrics and Gynaecology, 124(6), doi:10.1111/1471-0528.14557. ISSN 1470-0328

Objective Induction of labour at 39 weeks for nulliparous women aged 35 years and over may prevent stillbirths and does not increase caesarean births, so it may be popular. But the overall costs and benefits of such a policy have not been compared.... Read More

Randomized trial of labor induction in women 35 years of age or older (2016)
Journal Article
Walker, K. F., Bugg, G. J., Macpherson, M., McCormick, C., Grace, N., Wildsmith, C., …Thornton, J. (2016). Randomized trial of labor induction in women 35 years of age or older. New England Journal of Medicine, 374(9), doi:10.1056/NEJMoa1509117. ISSN 0028-4793

BACKGROUND The risk of antepartum stillbirth at term is higher among women 35 years of age or older than among younger women. Labor induction may reduce the risk of stillbirth, but it also may increase the risk of cesarean delivery, which already is... Read More

Cord pilot trial: update to randomised trial protocol (2015)
Journal Article
Bradshaw, L. E., Pushpa-Rajah, A., Dorling, J., Mitchell, E. J., & Duley, L. (2015). Cord pilot trial: update to randomised trial protocol. Trials, 16, 1-3. doi:10.1186/s13063-015-0936-2

Background: The Cord Pilot Trial aimed to assess the feasibility of conducting a large UK randomised trial to compare the effects of alternative polices for timing of cord clamping (immediate within 20 seconds or deferred after at least 2 minutes) fo... Read More